ClinVar Miner

Variants in gene KCNH2 with conflicting interpretations

Y axis minimum submission review status: Y axis collection method:
X axis minimum submission review status: X axis collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than two submissions, it may have multiple conflicts and therefore be counted in more than one conflict column. If this is the case, the "Variants with any kind of conflict" cell will be less than the sum of the conflicted variants cells to its left.

Variants with only 1 submission Variants with at least 2 submissions and no conflicts Variants with a synonymous conflict
(e.g. benign vs non-pathogenic)
Variants with a confidence conflict
(e.g. benign vs likely benign)
Variants with a benign or likely benign vs uncertain conflict Variants with a category conflict
(e.g. benign vs affects)
Variants with a clinically significant conflict
(e.g. benign vs pathogenic)
Variants with any kind of conflict
908 277 0 85 41 3 37 144

Significance breakdown #

In the table below, cells that correspond to a term paired with itself represent synonymous conflicts, i.e. variants that have been annotated with different terms that map to the same standard term. To compare the terms that were actually submitted, check the box in the filters section at the top of this page.

pathogenic likely pathogenic uncertain significance likely benign benign association drug response protective risk factor
pathogenic 0 35 20 2 1 1 1 1 0
likely pathogenic 34 0 21 1 0 0 0 0 1
uncertain significance 19 21 0 39 16 0 0 0 1
likely benign 1 1 39 0 50 0 0 0 1
benign 0 0 16 50 0 0 0 0 0
risk factor 0 1 1 1 0 0 0 0 0

All variants with conflicting interpretations #

Total variants: 144
Download table as spreadsheet
HGVS dbSNP
NM_172056.2(KCNH2):c.1035C>T (p.Gly345=) rs576125279
NM_172056.2(KCNH2):c.1039C>T (p.Pro347Ser) rs138776684
NM_172056.2(KCNH2):c.1128+7G>A rs200884259
NM_172056.2(KCNH2):c.1128G>A (p.Gln376=) rs770047651
NM_172056.2(KCNH2):c.1129-1G>A rs794728478
NM_172056.2(KCNH2):c.1149C>T (p.Asp383=) rs201995634
NM_172056.2(KCNH2):c.1262C>T (p.Thr421Met) rs199472894
NM_172056.2(KCNH2):c.128A>G (p.Tyr43Cys) rs199472836
NM_172056.2(KCNH2):c.1320G>T (p.Pro440=) rs144926928
NM_172056.2(KCNH2):c.1332G>A (p.Glu444=) rs9770044
NM_172056.2(KCNH2):c.1341C>T (p.Tyr447=) rs367570298
NM_172056.2(KCNH2):c.1342G>T (p.Ala448Ser) rs767723985
NM_172056.2(KCNH2):c.1353G>A (p.Pro451=) rs763446458
NM_172056.2(KCNH2):c.1437C>T (p.Asn479=) rs188818227
NM_172056.2(KCNH2):c.1467C>T (p.Ile489=) rs740952
NM_172056.2(KCNH2):c.1496T>G (p.Leu499Arg) rs794728370
NM_172056.2(KCNH2):c.1500C>A (p.Ile500=) rs147126965
NM_172056.2(KCNH2):c.1501G>A (p.Asp501Asn) rs199472912
NM_172056.2(KCNH2):c.1525G>A (p.Asp509Asn) rs370637245
NM_172056.2(KCNH2):c.1528C>T (p.Leu510=) rs75648145
NM_172056.2(KCNH2):c.1539C>T (p.Phe513=) rs1805120
NM_172056.2(KCNH2):c.1558-5C>T rs114186001
NM_172056.2(KCNH2):c.1563C>T (p.Ile521=) rs143011005
NM_172056.2(KCNH2):c.1581G>A (p.Ala527=) rs150275982
NM_172056.2(KCNH2):c.1600C>A (p.Arg534Ser) rs199472916
NM_172056.2(KCNH2):c.1635C>T (p.Tyr545=) rs200692436
NM_172056.2(KCNH2):c.1641G>A (p.Ala547=) rs149902084
NM_172056.2(KCNH2):c.167G>T (p.Arg56Leu) rs199472845
NM_172056.2(KCNH2):c.1682C>T (p.Ala561Val) rs121912504
NM_172056.2(KCNH2):c.1683G>A (p.Ala561=) rs140366118
NM_172056.2(KCNH2):c.1684C>T (p.His562Tyr) rs794728481
NM_172056.2(KCNH2):c.1692A>G (p.Leu564=) rs1805121
NM_172056.2(KCNH2):c.1701del (p.Trp568fs) rs794728440
NM_172056.2(KCNH2):c.1711A>G (p.Ile571Val) rs199472928
NM_172056.2(KCNH2):c.1750G>A (p.Gly584Ser) rs199473428
NM_172056.2(KCNH2):c.1750G>T (p.Gly584Cys) rs199473428
NM_172056.2(KCNH2):c.1800C>T (p.Ser600=) rs143518632
NM_172056.2(KCNH2):c.1801G>A (p.Gly601Ser) rs199472936
NM_172056.2(KCNH2):c.1809C>T (p.Gly603=) rs41314375
NM_172056.2(KCNH2):c.1814C>T (p.Pro605Leu) rs199472938
NM_172056.2(KCNH2):c.1838C>T (p.Thr613Met) rs199473524
NM_172056.2(KCNH2):c.1847A>G (p.Tyr616Cys) rs199472946
NM_172056.2(KCNH2):c.1882G>A (p.Gly628Ser) rs121912507
NM_172056.2(KCNH2):c.1886A>C (p.Asn629Thr) rs199472957
NM_172056.2(KCNH2):c.1887C>T (p.Asn629=) rs41307295
NM_172056.2(KCNH2):c.188C>A (p.Pro63His) rs766379103
NM_172056.2(KCNH2):c.1894C>T (p.Pro632Ser) rs199473527
NM_172056.2(KCNH2):c.1898A>G (p.Asn633Ser) rs199472961
NM_172056.2(KCNH2):c.1918T>C (p.Phe640Leu) rs199473529
NM_172056.2(KCNH2):c.1956T>C (p.Tyr652=) rs1137617
NM_172056.2(KCNH2):c.1973A>G (p.Asn658Ser) rs1057523338
NM_172056.2(KCNH2):c.1979C>T (p.Ser660Leu) rs199472979
NM_172056.2(KCNH2):c.2053C>T (p.Arg685Cys) rs778135438
NM_172056.2(KCNH2):c.2078T>C (p.Leu693Pro) rs199472983
NM_172056.2(KCNH2):c.2083C>T (p.Gln695Ter) rs1064794793
NM_172056.2(KCNH2):c.209A>G (p.His70Arg) rs199473419
NM_172056.2(KCNH2):c.2127C>T (p.Asn709=) rs768572372
NM_172056.2(KCNH2):c.2131A>G (p.Ile711Val) rs199473532
NM_172056.2(KCNH2):c.2145+1G>A rs886039385
NM_172056.2(KCNH2):c.2145+9A>T rs371749379
NM_172056.2(KCNH2):c.2145G>A (p.Ala715=) rs794728384
NM_172056.2(KCNH2):c.215C>A (p.Pro72Gln) rs199473421
NM_172056.2(KCNH2):c.2204C>T (p.Ser735Leu) rs199472988
NM_172056.2(KCNH2):c.221C>T (p.Thr74Met) rs199473422
NM_172056.2(KCNH2):c.2246G>T (p.Gly749Val) rs199472989
NM_172056.2(KCNH2):c.2254C>T (p.Arg752Trp) rs199472990
NM_172056.2(KCNH2):c.2255G>A (p.Arg752Gln) rs121912512
NM_172056.2(KCNH2):c.2320G>T (p.Asp774Tyr) rs199472995
NM_172056.2(KCNH2):c.2331C>T (p.Thr777=) rs41307292
NM_172056.2(KCNH2):c.2350C>T (p.Arg784Trp) rs12720441
NM_172056.2(KCNH2):c.2360T>A (p.Ile787Asn) rs794728387
NM_172056.2(KCNH2):c.2371C>T (p.Arg791Trp) rs138498207
NM_172056.2(KCNH2):c.2382C>T (p.Val794=) rs777801910
NM_172056.2(KCNH2):c.2390C>A (p.Ala797Asp) rs794728389
NM_172056.2(KCNH2):c.2399G>T (p.Gly800Val) rs794728391
NM_172056.2(KCNH2):c.2414C>T (p.Ala805Val) rs201873431
NM_172056.2(KCNH2):c.2503del (p.Leu835fs) rs546898924
NM_172056.2(KCNH2):c.2554G>A (p.Gly852Arg) rs139247073
NM_172056.2(KCNH2):c.2576C>T (p.Thr859Met) rs41314366
NM_172056.2(KCNH2):c.298C>G (p.Arg100Gly) rs121912515
NM_172056.2(KCNH2):c.342C>T (p.Pro114=) rs532959204
NM_172056.2(KCNH2):c.422C>T (p.Pro141Leu) rs199472864
NM_172056.2(KCNH2):c.442C>T (p.Arg148Trp) rs139544114
NM_172056.2(KCNH2):c.453dup (p.Thr152fs) rs761863251
NM_172056.2(KCNH2):c.473-7C>T rs146570628
NM_172056.2(KCNH2):c.51C>G (p.Thr17=) rs144338227
NM_172056.2(KCNH2):c.524C>A (p.Ala175Asp) rs776541110
NM_172056.2(KCNH2):c.526C>T (p.Arg176Trp) rs36210422
NM_172056.2(KCNH2):c.542G>A (p.Arg181Gln) rs41308954
NM_172056.2(KCNH2):c.551_559GCGCGGGCG[1] (p.184_186GAG[1]) rs551056698
NM_172056.2(KCNH2):c.558C>T (p.Gly186=) rs139533994
NM_172056.2(KCNH2):c.568G>A (p.Ala190Thr) rs150817714
NM_172056.2(KCNH2):c.621C>T (p.Ser207=) rs41314417
NM_172056.2(KCNH2):c.66dup (p.Glu23Ter) rs1554431441
NM_172056.2(KCNH2):c.77-5C>G rs72549419
NM_172056.2(KCNH2):c.817C>A (p.Arg273=) rs552583527
NM_172056.2(KCNH2):c.916G>C (p.Gly306Arg) rs199472884
NM_172056.2(KCNH2):c.934C>T (p.Arg312Cys) rs199472885
NM_172056.2(KCNH2):c.982C>T (p.Arg328Cys) rs199473505
NM_172057.2(KCNH2):c.1394T>G (p.Phe465Cys) rs199472999
NM_172057.2(KCNH2):c.1433C>T (p.Ser478Leu) rs121912510
NM_172057.2(KCNH2):c.1434G>A (p.Ser478=) rs72549418
NM_172057.2(KCNH2):c.1447C>T (p.Arg483Trp) rs199473538
NM_172057.2(KCNH2):c.1489G>A (p.Asp497Asn) rs199473005
NM_172057.2(KCNH2):c.1490A>G (p.Asp497Gly) rs199473004
NM_172057.2(KCNH2):c.1516C>T (p.Pro506Ser) rs199473006
NM_172057.2(KCNH2):c.1587G>A (p.Pro529=) rs199828796
NM_172057.2(KCNH2):c.1640G>A (p.Arg547His) rs199473432
NM_172057.2(KCNH2):c.1645T>G (p.Leu549Val) rs765427343
NM_172057.2(KCNH2):c.1654C>T (p.Arg552Cys) rs201627778
NM_172057.2(KCNH2):c.1670A>C (p.Lys557Thr) rs1805123
NM_172057.2(KCNH2):c.1672+8G>A rs200032281
NM_172057.2(KCNH2):c.1704_1708dup (p.Pro570fs) rs794728449
NM_172057.2(KCNH2):c.1718C>T (p.Ala573Val) rs77331749
NM_172057.2(KCNH2):c.1730C>T (p.Pro577Leu) rs76420733
NM_172057.2(KCNH2):c.1751G>A (p.Gly584Glu) rs199473009
NM_172057.2(KCNH2):c.1765dup (p.Glu589fs) rs794728458
NM_172057.2(KCNH2):c.1823G>A (p.Arg608His) rs199473011
NM_172057.2(KCNH2):c.1840C>T (p.Arg614Cys) rs141401803
NM_172057.2(KCNH2):c.1843C>G (p.Leu615Val) rs199473012
NM_172057.2(KCNH2):c.1884G>A (p.Pro628=) rs75005975
NM_172057.2(KCNH2):c.1921A>G (p.Ser641Gly) rs76649554
NM_172057.2(KCNH2):c.1928C>T (p.Thr643Ile) rs149955375
NM_172057.2(KCNH2):c.1974C>T (p.Phe658=) rs368954514
NM_172057.2(KCNH2):c.2043C>T (p.Ser681=) rs199767579
NM_172057.2(KCNH2):c.2077_2078dup (p.Pro694fs) rs1554424079
NM_172057.2(KCNH2):c.2079_2089del (p.Pro694fs) rs794728466
NM_172057.2(KCNH2):c.2088C>T (p.Gly696=) rs373414022
NM_172057.2(KCNH2):c.2091C>T (p.Asp697=) rs200799870
NM_172057.2(KCNH2):c.2092G>A (p.Val698Met) rs199473544
NM_172057.2(KCNH2):c.2105T>C (p.Leu702Pro) rs886039064
NM_172057.2(KCNH2):c.2113C>T (p.Leu705Phe) rs199473025
NM_172057.2(KCNH2):c.2120G>T (p.Arg707Leu) rs36210421
NM_172057.2(KCNH2):c.2132+12C>A rs72549420
NM_172057.2(KCNH2):c.2133-4C>T rs181119727
NM_172057.2(KCNH2):c.2144G>A (p.Arg715Gln) rs41307270
NM_172057.2(KCNH2):c.2183A>G (p.Gln728Arg) rs151031345
NM_172057.2(KCNH2):c.2208C>T (p.Pro736=) rs41312087
NM_172057.2(KCNH2):c.2311-13GT[2] rs41313749
NM_172057.2(KCNH2):c.2328G>A (p.Ala776=) rs376180501
NM_172057.2(KCNH2):c.2346G>A (p.Pro782=) rs371473271
NM_172057.2(KCNH2):c.2416A>T (p.Thr806Ser) rs778879572
NM_172057.2(KCNH2):c.78C>T (p.Ala26=) rs200324802
Single allele

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