ClinVar Miner

Variants in gene KRAS with conflicting interpretations

Y axis minimum submission review status: Y axis collection method:
X axis minimum submission review status: X axis collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than two submissions, it may have multiple conflicts and therefore be counted in more than one conflict column. If this is the case, the "Variants with any kind of conflict" cell will be less than the sum of the conflicted variants cells to its left.

Variants with only 1 submission per condition Variants with at least 2 submissions on the same condition and no conflicts Variants with a synonymous conflict
(e.g. benign vs non-pathogenic)
Variants with a confidence conflict
(e.g. benign vs likely benign)
Variants with a benign or likely benign vs uncertain conflict Variants with a category conflict
(e.g. benign vs affects)
Variants with a clinically significant conflict
(e.g. benign vs pathogenic)
Variants with any conflict
219 25 0 15 4 1 9 24

Significance breakdown #

In the table below, cells that correspond to a term paired with itself represent synonymous conflicts, i.e. variants that have been annotated with different terms that map to the same standard term. To compare the terms that were actually submitted, check the box in the filters section at the top of this page.

pathogenic likely pathogenic uncertain significance likely benign benign drug response
pathogenic 0 6 7 0 0 0
likely pathogenic 6 0 3 0 0 0
uncertain significance 7 3 0 3 3 1
likely benign 0 0 3 0 9 0
benign 0 0 3 9 0 0
drug response 0 0 1 0 0 0

All variants with conflicting interpretations #

Total variants: 24
Download table as spreadsheet
NM_004985.5(KRAS):c.-27C>T rs587781013
NM_004985.5(KRAS):c.-48G>A rs532564755
NM_004985.5(KRAS):c.108A>G (p.Ile36Met) rs727503109
NM_004985.5(KRAS):c.13A>G (p.Lys5Glu) rs193929331
NM_004985.5(KRAS):c.198A>G (p.Ala66=) rs200229810
NM_004985.5(KRAS):c.24A>G (p.Val8=) rs147406419
NM_004985.5(KRAS):c.264A>G (p.Lys88=) rs370920665
NM_004985.5(KRAS):c.34G>A (p.Gly12Ser) rs121913530
NM_004985.5(KRAS):c.35G>A (p.Gly12Asp) rs121913529
NM_004985.5(KRAS):c.35G>T (p.Gly12Val) rs121913529
NM_004985.5(KRAS):c.37G>T (p.Gly13Cys) rs121913535
NM_004985.5(KRAS):c.38G>A (p.Gly13Asp) rs112445441
NM_004985.5(KRAS):c.38G>T (p.Gly13Val) rs112445441
NM_004985.5(KRAS):c.40G>A (p.Val14Ile) rs104894365
NM_004985.5(KRAS):c.451-14T>C rs372508498
NM_004985.5(KRAS):c.451-5535A>C rs201170656
NM_004985.5(KRAS):c.451-5560T>A rs373169526
NM_004985.5(KRAS):c.451-5565G>A rs200970347
NM_004985.5(KRAS):c.451-5604T>C rs397517476
NM_004985.5(KRAS):c.528GAA[1] (p.Lys180del) rs397517043
NM_033360.4(KRAS):c.175G>T (p.Ala59Ser) rs121913528
NM_033360.4(KRAS):c.194G>T (p.Ser65Ile) rs1555194026
NM_033360.4(KRAS):c.436G>A (p.Ala146Thr) rs121913527
NM_033360.4(KRAS):c.439A>G (p.Lys147Glu) rs387907206

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