ClinVar Miner

Variants in gene LRP2 with conflicting interpretations "likely benign" and "uncertain significance"

Submission 1 (likely benign) minimum review status: Submission 1 (likely benign) method:
Submission 2 (uncertain significance) minimum review status: Submission 2 (uncertain significance) method:
Gene type:
ClinVar version:
Total variants with conflicting interpretations: 85
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HGVS dbSNP gnomAD frequency
NM_004525.3(LRP2):c.923-6G>A rs144147038 0.00611
NM_004525.3(LRP2):c.8892G>A (p.Arg2964=) rs149148763 0.00557
NM_004525.3(LRP2):c.149C>G (p.Thr50Ser) rs114460450 0.00342
NM_004525.3(LRP2):c.10937G>A (p.Arg3646His) rs142549310 0.00298
NM_004525.3(LRP2):c.1973A>G (p.Tyr658Cys) rs111360923 0.00248
NM_004525.3(LRP2):c.5390A>G (p.Asn1797Ser) rs138070797 0.00234
NM_004525.3(LRP2):c.11663G>A (p.Arg3888His) rs77686710 0.00218
NM_004525.3(LRP2):c.13685T>C (p.Val4562Ala) rs142245618 0.00201
NM_004525.3(LRP2):c.6850A>G (p.Thr2284Ala) rs35413340 0.00196
NM_004525.3(LRP2):c.12725A>G (p.Asp4242Gly) rs35942532 0.00171
NM_004525.3(LRP2):c.4351G>T (p.Val1451Phe) rs146289506 0.00164
NM_004525.3(LRP2):c.6473A>C (p.Asn2158Thr) rs34052957 0.00157
NM_004525.3(LRP2):c.9477G>A (p.Met3159Ile) rs144322413 0.00152
NM_004525.3(LRP2):c.7406A>G (p.Asp2469Gly) rs116507519 0.00143
NM_004525.3(LRP2):c.2178G>T (p.Leu726Phe) rs144451000 0.00139
NM_004525.3(LRP2):c.3110G>A (p.Arg1037Lys) rs147058423 0.00133
NM_004525.3(LRP2):c.5209C>T (p.Leu1737Phe) rs149469954 0.00126
NM_004525.3(LRP2):c.13921A>T (p.Thr4641Ser) rs79179577 0.00123
NM_004525.3(LRP2):c.170C>T (p.Ala57Val) rs115350461 0.00111
NM_004525.3(LRP2):c.2603C>G (p.Thr868Ser) rs150752263 0.00100
NM_004525.3(LRP2):c.6176C>T (p.Ser2059Phe) rs148299415 0.00098
NM_004525.3(LRP2):c.4831C>T (p.Leu1611=) rs151079411 0.00091
NM_004525.3(LRP2):c.6858T>A (p.Phe2286Leu) rs140918583 0.00089
NM_004525.3(LRP2):c.9311G>A (p.Ser3104Asn) rs139523655 0.00089
NM_004525.3(LRP2):c.987G>A (p.Ala329=) rs141751667 0.00084
NM_004525.3(LRP2):c.9650A>G (p.Tyr3217Cys) rs143150497 0.00083
NM_004525.3(LRP2):c.6160G>A (p.Asp2054Asn) rs138269726 0.00078
NM_004525.3(LRP2):c.1176C>T (p.Gly392=) rs369145798 0.00070
NM_004525.3(LRP2):c.6938C>T (p.Pro2313Leu) rs73035708 0.00069
NM_004525.3(LRP2):c.4803C>T (p.Cys1601=) rs141068435 0.00065
NM_004525.3(LRP2):c.7747G>A (p.Val2583Met) rs145201961 0.00063
NM_004525.3(LRP2):c.11264-14C>G rs377424162 0.00062
NM_004525.3(LRP2):c.4928G>A (p.Arg1643Gln) rs147688332 0.00059
NM_004525.3(LRP2):c.10165A>G (p.Ile3389Val) rs140272085 0.00055
NM_004525.3(LRP2):c.1189A>G (p.Ile397Val) rs140575982 0.00055
NM_004525.3(LRP2):c.7866C>T (p.Asp2622=) rs139514301 0.00047
NM_004525.3(LRP2):c.8901C>G (p.Pro2967=) rs145179638 0.00045
NM_004525.3(LRP2):c.2320+9G>A rs368933798 0.00044
NM_004525.3(LRP2):c.6553C>T (p.Leu2185Phe) rs143884041 0.00043
NM_004525.3(LRP2):c.12421G>A (p.Val4141Ile) rs150382715 0.00041
NM_004525.3(LRP2):c.9363C>T (p.Gly3121=) rs146783211 0.00039
NM_004525.3(LRP2):c.11322G>A (p.Ser3774=) rs141727314 0.00034
NM_004525.3(LRP2):c.1731G>A (p.Arg577=) rs142698246 0.00031
NM_004525.3(LRP2):c.3551-9C>A rs373882047 0.00030
NM_004525.3(LRP2):c.10880G>T (p.Ser3627Ile) rs138660534 0.00027
NM_004525.3(LRP2):c.5107C>T (p.Pro1703Ser) rs141260047 0.00024
NM_004525.3(LRP2):c.230A>T (p.Glu77Val) rs200113428 0.00021
NM_004525.3(LRP2):c.3128A>G (p.Tyr1043Cys) rs201299366 0.00021
NM_004525.3(LRP2):c.6130G>A (p.Ala2044Thr) rs142266106 0.00021
NM_004525.3(LRP2):c.11478G>A (p.Ala3826=) rs150464677 0.00019
NM_004525.3(LRP2):c.12958A>G (p.Ile4320Val) rs141452561 0.00019
NM_004525.3(LRP2):c.10661G>A (p.Arg3554Gln) rs139257219 0.00018
NM_004525.3(LRP2):c.8073C>T (p.His2691=) rs146772976 0.00018
NM_004525.3(LRP2):c.2210C>T (p.Ser737Leu) rs201860953 0.00017
NM_004525.3(LRP2):c.12687T>C (p.Gly4229=) rs140195786 0.00016
NM_004525.3(LRP2):c.5155G>C (p.Gly1719Arg) rs144054579 0.00016
NM_004525.3(LRP2):c.8132G>A (p.Arg2711His) rs190037522 0.00015
NM_004525.3(LRP2):c.12756C>T (p.Asp4252=) rs201793817 0.00012
NM_004525.3(LRP2):c.5370A>G (p.Gln1790=) rs201155152 0.00011
NM_004525.3(LRP2):c.5553C>T (p.His1851=) rs369998522 0.00011
NM_004525.3(LRP2):c.8169C>T (p.Asn2723=) rs200369596 0.00011
NM_004525.3(LRP2):c.8112C>A (p.Ser2704=) rs148473513 0.00010
NM_004525.3(LRP2):c.9066C>T (p.Ser3022=) rs374380173 0.00010
NM_004525.3(LRP2):c.10906C>T (p.Arg3636Trp) rs747833963 0.00009
NM_004525.3(LRP2):c.12296-4G>A rs375166826 0.00009
NM_004525.3(LRP2):c.7284T>G (p.Ser2428Arg) rs373362950 0.00009
NM_004525.3(LRP2):c.1425C>T (p.Asp475=) rs186484839 0.00007
NM_004525.3(LRP2):c.630C>T (p.Asp210=) rs368336310 0.00006
NM_004525.3(LRP2):c.3495G>A (p.Ser1165=) rs186494101 0.00005
NM_004525.3(LRP2):c.10704G>A (p.Pro3568=) rs756473581 0.00004
NM_004525.3(LRP2):c.2813G>A (p.Arg938Gln) rs372927481 0.00004
NM_004525.3(LRP2):c.770-12T>C rs138572086 0.00004
NM_004525.3(LRP2):c.13002C>T (p.Cys4334=) rs774133574 0.00003
NM_004525.3(LRP2):c.3573A>G (p.Gln1191=) rs750430784 0.00002
NM_004525.3(LRP2):c.39C>T (p.Leu13=) rs529649802 0.00002
NM_004525.3(LRP2):c.2599A>G (p.Thr867Ala) rs143822500 0.00001
NM_004525.3(LRP2):c.5867T>G (p.Leu1956Arg) rs756470766 0.00001
NM_004525.3(LRP2):c.11568G>A (p.Pro3856=) rs745949029
NM_004525.3(LRP2):c.12125G>A (p.Arg4042His) rs199874294
NM_004525.3(LRP2):c.169G>T (p.Ala57Ser) rs147295930
NM_004525.3(LRP2):c.1773-3C>T
NM_004525.3(LRP2):c.3932G>A (p.Arg1311His) rs140748929
NM_004525.3(LRP2):c.5648+7A>C rs775694684
NM_004525.3(LRP2):c.6470-4A>G
NM_004525.3(LRP2):c.770-4dup

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