ClinVar Miner

Variants in gene LRP5 with conflicting interpretations

See also:
Y axis minimum submission review status: Y axis collection method:
X axis minimum submission review status: X axis collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than two submissions, it may have multiple conflicts and therefore be counted in more than one conflict column. If this is the case, the "Variants with any kind of conflict" cell will be less than the sum of the conflicted variants cells to its left.

Variants with only 1 submission per condition Variants with at least 2 submissions on the same condition and no conflicts Variants with a synonymous conflict
(e.g. benign vs non-pathogenic) 		Variants with a confidence conflict
(e.g. benign vs likely benign) 		Variants with a benign or likely benign vs uncertain conflict Variants with a category conflict
(e.g. benign vs affects) 		Variants with a clinically significant conflict
(e.g. benign vs pathogenic) 		Variants with any conflict
1867 296 0 63 53 1 18 123

Significance breakdown #

In the table below, cells that correspond to a term paired with itself represent synonymous conflicts, i.e. variants that have been annotated with different terms that map to the same standard term. To compare the terms that were actually submitted, check the box in the filters section at the top of this page.

pathogenic likely pathogenic uncertain significance likely benign benign affects
pathogenic 0 8 6 1 0 0
likely pathogenic 8 0 12 0 1 0
uncertain significance 6 12 0 52 10 0
likely benign 1 0 52 0 55 0
benign 0 1 10 55 0 1
affects 0 0 0 0 1 0

All variants with conflicting interpretations #

Total variants: 123
Download table as spreadsheet
HGVS dbSNP gnomAD frequency
NM_002335.4(LRP5):c.2220C>T (p.Asn740=) rs2306862 0.11683
NM_002335.4(LRP5):c.3989C>T (p.Ala1330Val) rs3736228 0.10701
NM_002335.4(LRP5):c.1999G>A (p.Val667Met) rs4988321 0.03472
NM_002335.4(LRP5):c.4788C>T (p.Thr1596=) rs113442867 0.01233
NM_002335.4(LRP5):c.3918G>A (p.Ala1306=) rs11574425 0.01064
NM_002335.4(LRP5):c.4574C>T (p.Ala1525Val) rs1127291 0.01003
NM_002335.4(LRP5):c.266A>G (p.Gln89Arg) rs41494349 0.00826
NM_002335.4(LRP5):c.3564G>A (p.Arg1188=) rs117289001 0.00762
NM_002335.4(LRP5):c.687-17C>T rs186410639 0.00751
NM_002335.4(LRP5):c.687-8G>A rs190810239 0.00718
NM_002335.4(LRP5):c.4000+9C>T rs148685646 0.00389
NM_002335.4(LRP5):c.4635C>T (p.Thr1545=) rs145406397 0.00373
NM_002335.4(LRP5):c.2139G>A (p.Val713=) rs34369535 0.00322
NM_002335.4(LRP5):c.4278T>C (p.Tyr1426=) rs142328132 0.00250
NM_002335.4(LRP5):c.4431C>T (p.His1477=) rs11574426 0.00238
NM_002335.4(LRP5):c.2124G>A (p.Ser708=) rs140977837 0.00230
NM_002335.4(LRP5):c.4209C>G (p.Val1403=) rs147671915 0.00226
NM_002335.4(LRP5):c.3107G>A (p.Arg1036Gln) rs61889560 0.00207
NM_002335.4(LRP5):c.4089C>T (p.Asp1363=) rs3736229 0.00195
NM_002335.4(LRP5):c.1968C>T (p.His656=) rs144847027 0.00194
NM_002335.4(LRP5):c.1801+675A>G rs555106014 0.00188
NM_002335.4(LRP5):c.4380C>T (p.Ser1460=) rs11574420 0.00182
NM_002335.4(LRP5):c.2295G>A (p.Ser765=) rs140955013 0.00156
NM_002335.4(LRP5):c.4623G>A (p.Thr1541=) rs139974816 0.00155
NM_002335.4(LRP5):c.1801+725G>A rs576510976 0.00128
NM_002335.4(LRP5):c.2193C>T (p.Asn731=) rs147388442 0.00108
NM_002335.4(LRP5):c.3990G>A (p.Ala1330=) rs147637431 0.00108
NM_002335.4(LRP5):c.3723A>G (p.Pro1241=) rs139554243 0.00100
NM_002335.4(LRP5):c.2529C>T (p.Asp843=) rs143204891 0.00099
NM_002335.4(LRP5):c.4195G>A (p.Val1399Ile) rs113315676 0.00097
NM_002335.4(LRP5):c.263A>G (p.Lys88Arg) rs78219242 0.00095
NM_002335.4(LRP5):c.2234C>T (p.Ala745Val) rs148550774 0.00083
NM_002335.4(LRP5):c.2544G>A (p.Pro848=) rs148271293 0.00083
NM_002335.4(LRP5):c.4112-14T>C rs200717286 0.00078
NM_002335.4(LRP5):c.1413-7T>A rs141889567 0.00077
NM_002335.4(LRP5):c.2637C>T (p.Arg879=) rs141174027 0.00069
NM_002335.4(LRP5):c.291C>T (p.Ala97=) rs146667935 0.00061
NM_002335.4(LRP5):c.686+13G>A rs377344481 0.00059
NM_002335.4(LRP5):c.1032G>C (p.Leu344=) rs143499301 0.00050
NM_002335.4(LRP5):c.518C>T (p.Thr173Met) rs80358306 0.00049
NM_002335.4(LRP5):c.4256A>G (p.Asn1419Ser) rs145750689 0.00048
NM_002335.4(LRP5):c.2324T>C (p.Ile775Thr) rs144983823 0.00046
NM_002335.4(LRP5):c.2445C>T (p.Asp815=) rs149080536 0.00046
NM_002335.4(LRP5):c.2829G>A (p.Pro943=) rs201018263 0.00046
NM_002335.4(LRP5):c.1585-9G>A rs202067798 0.00042
NM_002335.4(LRP5):c.2182A>T (p.Met728Leu) rs149241739 0.00041
NM_002335.4(LRP5):c.4511C>T (p.Pro1504Leu) rs201475647 0.00039
NM_002335.4(LRP5):c.144C>T (p.Ala48=) rs776920568 0.00036
NM_002335.4(LRP5):c.3403C>T (p.Arg1135Cys) rs143396225 0.00032
NM_002335.4(LRP5):c.1818G>A (p.Ala606=) rs148603249 0.00031
NM_002335.4(LRP5):c.675C>T (p.Asp225=) rs138207107 0.00031
NM_002335.4(LRP5):c.4565C>T (p.Pro1522Leu) rs200624778 0.00026
NM_002335.4(LRP5):c.1738G>A (p.Val580Ile) rs149524398 0.00024
NM_002335.4(LRP5):c.1395A>C (p.Ala465=) rs200075657 0.00022
NM_002335.4(LRP5):c.639C>T (p.Asp213=) rs150859573 0.00022
NM_002335.4(LRP5):c.2091+5C>T rs202064462 0.00021
NM_002335.4(LRP5):c.3361A>G (p.Asn1121Asp) rs80358317 0.00021
NM_002335.4(LRP5):c.4049T>G (p.Leu1350Arg) rs531205284 0.00018
NM_002335.4(LRP5):c.*4C>T rs374104266 0.00017
NM_002335.4(LRP5):c.2115C>T (p.Asn705=) rs145456776 0.00017
NM_002335.4(LRP5):c.1299C>T (p.Thr433=) rs145362529 0.00016
NM_002335.4(LRP5):c.141C>T (p.Asp47=) rs375980894 0.00012
NM_002335.4(LRP5):c.3245A>G (p.Tyr1082Cys) rs113804402 0.00011
NM_002335.4(LRP5):c.4488+10G>A rs202206612 0.00010
NM_002335.4(LRP5):c.4643G>T (p.Cys1548Phe) rs147618989 0.00010
NM_002335.4(LRP5):c.1496A>G (p.Asn499Ser) rs150771999 0.00009
NM_002335.4(LRP5):c.3901G>A (p.Ala1301Thr) rs149166384 0.00008
NM_002335.4(LRP5):c.996C>T (p.Asn332=) rs956302502 0.00007
NM_002335.4(LRP5):c.1077G>A (p.Thr359=) rs200179967 0.00006
NM_002335.4(LRP5):c.4272C>T (p.His1424=) rs145226802 0.00006
NM_002335.4(LRP5):c.685C>T (p.Arg229Trp) rs766589610 0.00006
NM_002335.4(LRP5):c.2467C>T (p.Leu823=) rs768741253 0.00005
NM_002335.4(LRP5):c.3697G>A (p.Asp1233Asn) rs146388120 0.00005
NM_002335.4(LRP5):c.4791G>C (p.Glu1597Asp) rs142508112 0.00005
NM_002335.4(LRP5):c.1331G>A (p.Arg444His) rs761049544 0.00004
NM_002335.4(LRP5):c.91+9G>C rs569517144 0.00004
NM_002335.4(LRP5):c.1002G>A (p.Arg334=) rs868085658 0.00003
NM_002335.4(LRP5):c.2241G>A (p.Leu747=) rs867927445 0.00003
NM_002335.4(LRP5):c.738C>T (p.Ser246=) rs768638466 0.00003
NM_002335.4(LRP5):c.1519G>A (p.Gly507Ser) rs765290711 0.00002
NM_002335.4(LRP5):c.1581C>T (p.Ile527=) rs780098863 0.00002
NM_002335.4(LRP5):c.4320G>A (p.Pro1440=) rs753598091 0.00002
NM_002335.4(LRP5):c.1182G>A (p.Val394=) rs746800397 0.00001
NM_002335.4(LRP5):c.1183C>T (p.Arg395Trp) rs1177481438 0.00001
NM_002335.4(LRP5):c.1300G>A (p.Asp434Asn) rs757888034 0.00001
NM_002335.4(LRP5):c.1321G>A (p.Glu441Lys) rs376152274 0.00001
NM_002335.4(LRP5):c.1330C>T (p.Arg444Cys) rs80358308 0.00001
NM_002335.4(LRP5):c.1348C>T (p.Arg450Cys) rs765695793 0.00001
NM_002335.4(LRP5):c.1480C>T (p.Arg494Trp) rs1270099780 0.00001
NM_002335.4(LRP5):c.1484G>A (p.Arg495His) rs200409162 0.00001
NM_002335.4(LRP5):c.1507G>A (p.Gly503Arg) rs766988509 0.00001
NM_002335.4(LRP5):c.199G>A (p.Ala67Thr) rs544861971 0.00001
NM_002335.4(LRP5):c.2463C>T (p.Thr821=) rs778180589 0.00001
NM_002335.4(LRP5):c.2555C>T (p.Thr852Met) rs1398692057 0.00001
NM_002335.4(LRP5):c.2964C>T (p.Asp988=) rs200117377 0.00001
NM_002335.4(LRP5):c.4359C>T (p.Cys1453=) rs755205426 0.00001
NM_002335.4(LRP5):c.4488+6G>T rs751829465 0.00001
NM_002335.4(LRP5):c.4651G>A (p.Asp1551Asn) rs724159827 0.00001
NM_002335.4(LRP5):c.480C>T (p.Pro160=) rs377114189 0.00001
NM_002335.4(LRP5):c.96G>A (p.Ser32=) rs202039395 0.00001
NM_002335.4(LRP5):c.-19del rs763941232
NM_002335.4(LRP5):c.1481G>A (p.Arg494Gln) rs121908664
NM_002335.4(LRP5):c.1732C>T (p.Arg578Trp)
NM_002335.4(LRP5):c.1828G>A (p.Gly610Arg) rs80358313
NM_002335.4(LRP5):c.209_210delinsAA (p.Phe70Ter) rs2098614719
NM_002335.4(LRP5):c.2254C>T (p.Arg752Trp) rs121908674
NM_002335.4(LRP5):c.2779G>A (p.Gly927Ser) rs764138752
NM_002335.4(LRP5):c.3446T>A (p.Leu1149Gln) rs200389686
NM_002335.4(LRP5):c.34CTG[11] (p.Leu19_Leu20dup) rs72555376
NM_002335.4(LRP5):c.34CTG[6] (p.Leu18_Leu20del) rs72555376
NM_002335.4(LRP5):c.34CTG[7] (p.Leu19_Leu20del) rs72555376
NM_002335.4(LRP5):c.34CTG[8] (p.Leu20del) rs72555376
NM_002335.4(LRP5):c.3552C>A (p.Thr1184=) rs764663599
NM_002335.4(LRP5):c.3763+2T>C
NM_002335.4(LRP5):c.4111+3G>A
NM_002335.4(LRP5):c.425G>C (p.Arg142Pro)
NM_002335.4(LRP5):c.4446G>C (p.Ser1482=) rs142191419
NM_002335.4(LRP5):c.4458G>A (p.Ser1486=) rs75571306
NM_002335.4(LRP5):c.4614C>T (p.Pro1538=) rs1421178463
NM_002335.4(LRP5):c.54_55insTTG (p.Leu20_Ala21insLeu)
NM_002335.4(LRP5):c.593A>G (p.Asn198Ser) rs1085307078
NM_002335.4(LRP5):c.724G>A (p.Ala242Thr) rs121908670
NM_002335.4(LRP5):c.943A>G (p.Ser315Gly)

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