ClinVar Miner

Variants in gene LRP5 with conflicting interpretations

Y axis minimum submission review status: Y axis collection method:
X axis minimum submission review status: X axis collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than two submissions, it may have multiple conflicts and therefore be counted in more than one conflict column. If this is the case, the "Variants with any kind of conflict" cell will be less than the sum of the conflicted variants cells to its left.

Variants with only 1 submission per condition Variants with at least 2 submissions on the same condition and no conflicts Variants with a synonymous conflict
(e.g. benign vs non-pathogenic)
Variants with a confidence conflict
(e.g. benign vs likely benign)
Variants with a benign or likely benign vs uncertain conflict Variants with a category conflict
(e.g. benign vs affects)
Variants with a clinically significant conflict
(e.g. benign vs pathogenic)
Variants with any conflict
546 39 0 15 19 1 5 38

Significance breakdown #

In the table below, cells that correspond to a term paired with itself represent synonymous conflicts, i.e. variants that have been annotated with different terms that map to the same standard term. To compare the terms that were actually submitted, check the box in the filters section at the top of this page.

pathogenic likely pathogenic uncertain significance likely benign benign affects
pathogenic 0 1 0 1 0 0
likely pathogenic 1 0 3 0 1 0
uncertain significance 0 3 0 17 3 0
likely benign 1 0 17 0 14 0
benign 0 1 3 14 0 1
affects 0 0 0 0 1 0

All variants with conflicting interpretations #

Total variants: 38
Download table as spreadsheet
HGVS dbSNP
NM_002335.4(LRP5):c.-19del rs763941232
NM_002335.4(LRP5):c.1002G>A (p.Arg334=) rs868085658
NM_002335.4(LRP5):c.1299C>T (p.Thr433=) rs145362529
NM_002335.4(LRP5):c.1330C>T (p.Arg444Cys) rs80358308
NM_002335.4(LRP5):c.1413-7T>A rs141889567
NM_002335.4(LRP5):c.144C>T (p.Ala48=) rs776920568
NM_002335.4(LRP5):c.1481G>A (p.Arg494Gln) rs121908664
NM_002335.4(LRP5):c.1585-9G>A rs202067798
NM_002335.4(LRP5):c.1818G>A (p.Ala606=) rs148603249
NM_002335.4(LRP5):c.1999G>A (p.Val667Met) rs4988321
NM_002335.4(LRP5):c.199G>A (p.Ala67Thr) rs544861971
NM_002335.4(LRP5):c.2124G>A (p.Ser708=) rs140977837
NM_002335.4(LRP5):c.2139G>A (p.Val713=) rs34369535
NM_002335.4(LRP5):c.2193C>T (p.Asn731=) rs147388442
NM_002335.4(LRP5):c.2220C>T (p.Asn740=) rs2306862
NM_002335.4(LRP5):c.2234C>T (p.Ala745Val) rs148550774
NM_002335.4(LRP5):c.2445C>T (p.Asp815=) rs149080536
NM_002335.4(LRP5):c.2529C>T (p.Asp843=) rs143204891
NM_002335.4(LRP5):c.263A>G (p.Lys88Arg) rs78219242
NM_002335.4(LRP5):c.3107G>A (p.Arg1036Gln) rs61889560
NM_002335.4(LRP5):c.3361A>G (p.Asn1121Asp) rs80358317
NM_002335.4(LRP5):c.34CTG[11] (p.Leu19_Leu20dup) rs72555376
NM_002335.4(LRP5):c.34CTG[8] (p.Leu20del) rs72555376
NM_002335.4(LRP5):c.3723A>G (p.Pro1241=) rs139554243
NM_002335.4(LRP5):c.3990G>A (p.Ala1330=) rs147637431
NM_002335.4(LRP5):c.4000+9C>T rs148685646
NM_002335.4(LRP5):c.4089C>T (p.Asp1363=) rs3736229
NM_002335.4(LRP5):c.4195G>A (p.Val1399Ile) rs113315676
NM_002335.4(LRP5):c.4272C>T (p.His1424=) rs145226802
NM_002335.4(LRP5):c.4278T>C (p.Tyr1426=) rs142328132
NM_002335.4(LRP5):c.4431C>T (p.His1477=) rs11574426
NM_002335.4(LRP5):c.4574C>T (p.Ala1525Val) rs1127291
NM_002335.4(LRP5):c.459G>A (p.Pro153=) rs78844574
NM_002335.4(LRP5):c.4623G>A (p.Thr1541=) rs139974816
NM_002335.4(LRP5):c.4788C>T (p.Thr1596=) rs113442867
NM_002335.4(LRP5):c.518C>T (p.Thr173Met) rs80358306
NM_002335.4(LRP5):c.639C>T (p.Asp213=) rs150859573
NM_002335.4(LRP5):c.685C>T (p.Arg229Trp) rs766589610

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