ClinVar Miner

Variants in gene LRRK2 with conflicting interpretations

Y axis minimum submission review status: Y axis collection method:
X axis minimum submission review status: X axis collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than two submissions, it may have multiple conflicts and therefore be counted in more than one conflict column. If this is the case, the "Variants with any kind of conflict" cell will be less than the sum of the conflicted variants cells to its left.

Variants with only 1 submission per condition Variants with at least 2 submissions on the same condition and no conflicts Variants with a synonymous conflict
(e.g. benign vs non-pathogenic)
Variants with a confidence conflict
(e.g. benign vs likely benign)
Variants with a benign or likely benign vs uncertain conflict Variants with a category conflict
(e.g. benign vs affects)
Variants with a clinically significant conflict
(e.g. benign vs pathogenic)
Variants with any conflict
301 10 25 16 45 1 4 71

Significance breakdown #

In the table below, cells that correspond to a term paired with itself represent synonymous conflicts, i.e. variants that have been annotated with different terms that map to the same standard term. To compare the terms that were actually submitted, check the box in the filters section at the top of this page.

pathogenic uncertain significance likely benign benign risk factor
pathogenic 9 2 3 4 1
uncertain significance 2 16 24 32 1
likely benign 3 24 0 16 1
benign 4 32 16 0 1
risk factor 1 1 1 1 0

All variants with conflicting interpretations #

Total variants: 71
Download table as spreadsheet
NM_198578.3(LRRK2):c.149A>G (p.His50Arg) rs2256408
NM_198578.4(LRRK2):c.1000G>A (p.Glu334Lys) rs78501232
NM_198578.4(LRRK2):c.1073C>T (p.Thr358Met) rs141262110
NM_198578.4(LRRK2):c.1256C>T (p.Ala419Val) rs34594498
NM_198578.4(LRRK2):c.1561A>G (p.Arg521Gly) rs35328937
NM_198578.4(LRRK2):c.1653C>G (p.Asn551Lys) rs7308720
NM_198578.4(LRRK2):c.177T>A (p.Asn59Lys) rs150422099
NM_198578.4(LRRK2):c.2022A>C (p.Val674=) rs72546319
NM_198578.4(LRRK2):c.2167A>G (p.Ile723Val) rs10878307
NM_198578.4(LRRK2):c.225G>A (p.Ala75=) rs75054132
NM_198578.4(LRRK2):c.2264C>T (p.Pro755Leu) rs34410987
NM_198578.4(LRRK2):c.2378G>T (p.Arg793Met) rs35173587
NM_198578.4(LRRK2):c.2481T>C (p.Ser827=) rs76890302
NM_198578.4(LRRK2):c.2594C>T (p.Ser865Phe) rs142700458
NM_198578.4(LRRK2):c.2857T>C (p.Leu953=) rs7966550
NM_198578.4(LRRK2):c.3018A>G (p.Ile1006Met) rs113217062
NM_198578.4(LRRK2):c.3333G>T (p.Gln1111His) rs78365431
NM_198578.4(LRRK2):c.3364A>G (p.Ile1122Val) rs34805604
NM_198578.4(LRRK2):c.3429C>T (p.Ser1143=) rs142989436
NM_198578.4(LRRK2):c.3451G>A (p.Ala1151Thr) rs74985840
NM_198578.4(LRRK2):c.356T>C (p.Leu119Pro) rs33995463
NM_198578.4(LRRK2):c.3574A>G (p.Ile1192Val) rs281865047
NM_198578.4(LRRK2):c.364C>T (p.Leu122=) rs41286468
NM_198578.4(LRRK2):c.3683G>C (p.Ser1228Thr) rs60185966
NM_198578.4(LRRK2):c.3777+7C>T rs41286480
NM_198578.4(LRRK2):c.3784C>G (p.Pro1262Ala) rs4640000
NM_198578.4(LRRK2):c.3960G>T (p.Arg1320Ser) rs77018758
NM_198578.4(LRRK2):c.3969A>G (p.Gln1323=) rs372245035
NM_198578.4(LRRK2):c.3974G>A (p.Arg1325Gln) rs72546338
NM_198578.4(LRRK2):c.4111A>G (p.Ile1371Val) rs17466213
NM_198578.4(LRRK2):c.4193G>A (p.Arg1398His) rs7133914
NM_198578.4(LRRK2):c.4229C>T (p.Thr1410Met) rs72546327
NM_198578.4(LRRK2):c.4269G>A (p.Lys1423=) rs11175964
NM_198578.4(LRRK2):c.4321C>G (p.Arg1441Gly) rs33939927
NM_198578.4(LRRK2):c.4321C>T (p.Arg1441Cys) rs33939927
NM_198578.4(LRRK2):c.4322G>A (p.Arg1441His) rs34995376
NM_198578.4(LRRK2):c.4337C>T (p.Pro1446Leu) rs74681492
NM_198578.4(LRRK2):c.4536+3A>G rs41286476
NM_198578.4(LRRK2):c.4541G>A (p.Arg1514Gln) rs35507033
NM_198578.4(LRRK2):c.457T>C (p.Leu153=) rs10878245
NM_198578.4(LRRK2):c.4624C>T (p.Pro1542Ser) rs33958906
NM_198578.4(LRRK2):c.4872C>A (p.Gly1624=) rs1427263
NM_198578.4(LRRK2):c.4883G>C (p.Arg1628Pro) rs33949390
NM_198578.4(LRRK2):c.4911A>G (p.Lys1637=) rs11176013
NM_198578.4(LRRK2):c.4937T>C (p.Met1646Thr) rs35303786
NM_198578.4(LRRK2):c.4939T>A (p.Ser1647Thr) rs11564148
NM_198578.4(LRRK2):c.4959A>G (p.Leu1653=) rs111503579
NM_198578.4(LRRK2):c.5096A>G (p.Tyr1699Cys) rs35801418
NM_198578.4(LRRK2):c.5163A>G (p.Ser1721=) rs79909111
NM_198578.4(LRRK2):c.5457T>C (p.Gly1819=) rs10878371
NM_198578.4(LRRK2):c.5510-9A>G rs41286460
NM_198578.4(LRRK2):c.5606T>C (p.Met1869Thr) rs35602796
NM_198578.4(LRRK2):c.5713G>C (p.Val1905Leu) rs754436306
NM_198578.4(LRRK2):c.5822G>A (p.Arg1941His) rs77428810
NM_198578.4(LRRK2):c.6055G>A (p.Gly2019Ser) rs34637584
NM_198578.4(LRRK2):c.6059T>C (p.Ile2020Thr) rs35870237
NM_198578.4(LRRK2):c.6187_6191del (p.Leu2062_Leu2063insTer) rs111739194
NM_198578.4(LRRK2):c.6241A>G (p.Asn2081Asp) rs33995883
NM_198578.4(LRRK2):c.6324G>A (p.Glu2108=) rs10878405
NM_198578.4(LRRK2):c.632C>T (p.Ala211Val) rs112794616
NM_198578.4(LRRK2):c.6428G>A (p.Arg2143His) rs201271001
NM_198578.4(LRRK2):c.6510C>A (p.Gly2170=) rs34869625
NM_198578.4(LRRK2):c.6566A>G (p.Tyr2189Cys) rs35658131
NM_198578.4(LRRK2):c.6801C>T (p.Thr2267=) rs148143226
NM_198578.4(LRRK2):c.683G>C (p.Cys228Ser) rs56108242
NM_198578.4(LRRK2):c.6929C>T (p.Thr2310Met) rs200002022
NM_198578.4(LRRK2):c.7067C>T (p.Thr2356Ile) rs113511708
NM_198578.4(LRRK2):c.7153G>A (p.Gly2385Arg) rs34778348
NM_198578.4(LRRK2):c.7155A>G (p.Gly2385=) rs33962975
NM_198578.4(LRRK2):c.7296C>G (p.Gly2432=) rs199964631
NM_198578.4(LRRK2):c.936G>T (p.Ala312=) rs41286466

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