ClinVar Miner

Variants in gene LRRK2 with conflicting interpretations "likely benign" and "uncertain significance"

Submission 1 (likely benign) minimum review status: Submission 1 (likely benign) method:
Submission 2 (uncertain significance) minimum review status: Submission 2 (uncertain significance) method:
Gene type:
ClinVar version:
Total variants with conflicting interpretations: 26
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HGVS dbSNP gnomAD frequency
NM_198578.4(LRRK2):c.1000G>A (p.Glu334Lys) rs78501232 0.00266
NM_198578.4(LRRK2):c.356T>C (p.Leu119Pro) rs33995463 0.00140
NM_198578.4(LRRK2):c.3777+7C>T rs41286480 0.00097
NM_198578.4(LRRK2):c.2378G>T (p.Arg793Met) rs35173587 0.00085
NM_198578.4(LRRK2):c.5606T>C (p.Met1869Thr) rs35602796 0.00060
NM_198578.4(LRRK2):c.7153G>A (p.Gly2385Arg) rs34778348 0.00058
NM_198578.4(LRRK2):c.6566A>G (p.Tyr2189Cys) rs35658131 0.00055
NM_198578.4(LRRK2):c.4536+3A>G rs41286476 0.00027
NM_198578.4(LRRK2):c.6801C>T (p.Thr2267=) rs148143226 0.00023
NM_198578.4(LRRK2):c.1324C>T (p.His442Tyr) rs568593066 0.00022
NM_198578.4(LRRK2):c.5799A>T (p.Ile1933=) rs139746572 0.00021
NM_198578.4(LRRK2):c.2769G>C (p.Gln923His) rs58559150 0.00020
NM_198578.4(LRRK2):c.177T>A (p.Asn59Lys) rs150422099 0.00012
NM_198578.4(LRRK2):c.632C>T (p.Ala211Val) rs112794616 0.00011
NM_198578.4(LRRK2):c.1073C>T (p.Thr358Met) rs141262110 0.00009
NM_198578.4(LRRK2):c.3960G>T (p.Arg1320Ser) rs77018758 0.00009
NM_198578.4(LRRK2):c.2771G>A (p.Arg924His) rs200795874 0.00008
NM_198578.4(LRRK2):c.3969A>G (p.Gln1323=) rs372245035 0.00004
NM_198578.4(LRRK2):c.1446A>G (p.Ala482=) rs757454147 0.00003
NM_198578.4(LRRK2):c.2070+9T>A rs201389324 0.00002
NM_198578.4(LRRK2):c.6582T>C (p.Val2194=) rs773085638 0.00002
NM_198578.4(LRRK2):c.839-4T>G rs748213808 0.00002
NM_198578.4(LRRK2):c.4883G>A (p.Arg1628His) rs33949390
NM_198578.4(LRRK2):c.5713G>C (p.Val1905Leu) rs754436306
NM_198578.4(LRRK2):c.606C>T (p.Asn202=) rs199854074
NM_198578.4(LRRK2):c.7296C>G (p.Gly2432=) rs199964631

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