Variants in gene LYST with conflicting interpretations "uncertain significance" and "likely benign"

Submission 1 (uncertain significance) minimum review status:		Submission 1 (uncertain significance) method:
Submission 2 (likely benign) minimum review status:		Submission 2 (likely benign) method:
Gene type: Distinguish antisense genes from sense genes
Show significances as they were submitted (without aggregation into standard terms)
		ClinVar version:

Total variants with conflicting interpretations: 80

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HGVS	dbSNP	gnomAD frequency
NM_000081.4(LYST):c.10941-7C>A	rs72761794	0.00614
NM_000081.4(LYST):c.5518T>G (p.Ser1840Ala)	rs115330112	0.00485
NM_000081.4(LYST):c.10800+4G>T	rs41308172	0.00441
NM_000081.4(LYST):c.6482A>C (p.Glu2161Ala)	rs147756847	0.00416
NM_000081.4(LYST):c.1686G>C (p.Gln562His)	rs77091385	0.00394
NM_000081.4(LYST):c.7870C>T (p.Arg2624Trp)	rs150306354	0.00280
NM_000081.4(LYST):c.8913T>G (p.Asn2971Lys)	rs34702903	0.00276
NM_000081.4(LYST):c.2363+4T>C	rs201398337	0.00252
NM_000081.4(LYST):c.3683A>G (p.Asn1228Ser)	rs145553827	0.00171
NM_000081.4(LYST):c.6710A>C (p.Gln2237Pro)	rs138443479	0.00148
NM_000081.4(LYST):c.4337G>A (p.Arg1446Gln)	rs111722949	0.00135
NM_000081.4(LYST):c.8487C>T (p.Ile2829=)	rs144597913	0.00126
NM_000081.4(LYST):c.7506A>G (p.Gln2502=)	rs140434436	0.00106
NM_000081.4(LYST):c.8027G>T (p.Ser2676Ile)	rs113209379	0.00086
NM_000081.4(LYST):c.2363+10dup	rs760632806	0.00058
NM_000081.4(LYST):c.4637C>T (p.Ala1546Val)	rs142983846	0.00054
NM_000081.4(LYST):c.11086G>A (p.Val3696Ile)	rs147221131	0.00052
NM_000081.4(LYST):c.8806G>A (p.Val2936Ile)	rs2753327	0.00052
NM_000081.4(LYST):c.9017A>G (p.Lys3006Arg)	rs140934482	0.00047
NM_000081.4(LYST):c.143A>G (p.His48Arg)	rs200132460	0.00046
NM_000081.4(LYST):c.692A>G (p.Gln231Arg)	rs147433918	0.00043
NM_000081.4(LYST):c.2946T>C (p.Tyr982=)	rs145892183	0.00034
NM_000081.4(LYST):c.2313G>A (p.Gln771=)	rs147220685	0.00031
NM_000081.4(LYST):c.6782G>A (p.Arg2261His)	rs147791378	0.00031
NM_000081.4(LYST):c.2963G>A (p.Arg988Gln)	rs150953050	0.00029
NM_000081.4(LYST):c.3394-14T>C	rs372892911	0.00029
NM_000081.4(LYST):c.6487G>A (p.Ala2163Thr)	rs201513511	0.00026
NM_000081.4(LYST):c.7368T>C (p.Asn2456=)	rs199631995	0.00026
NM_000081.4(LYST):c.4578T>A (p.Asn1526Lys)	rs117609949	0.00025
NM_000081.4(LYST):c.2754G>A (p.Glu918=)	rs373577384	0.00022
NM_000081.4(LYST):c.3898A>G (p.Ile1300Val)	rs199855658	0.00021
NM_000081.4(LYST):c.4006+8G>A	rs369153654	0.00021
NM_000081.4(LYST):c.9045-13T>C	rs181450025	0.00021
NM_000081.4(LYST):c.10477T>C (p.Phe3493Leu)	rs200511787	0.00020
NM_000081.4(LYST):c.595G>A (p.Asp199Asn)	rs552391792	0.00018
NM_000081.4(LYST):c.6291C>T (p.Ala2097=)	rs199857997	0.00016
NM_000081.4(LYST):c.6388G>A (p.Asp2130Asn)	rs148371004	0.00014
NM_000081.4(LYST):c.7806A>G (p.Gln2602=)	rs372754364	0.00014
NM_000081.4(LYST):c.8151T>C (p.Ile2717=)	rs201045270	0.00012
NM_000081.4(LYST):c.10221C>T (p.Tyr3407=)	rs146457386	0.00010
NM_000081.4(LYST):c.196T>C (p.Leu66=)	rs138393416	0.00010
NM_000081.4(LYST):c.2826A>G (p.Pro942=)	rs149558986	0.00010
NM_000081.4(LYST):c.281C>T (p.Thr94Ile)	rs777389303	0.00009
NM_000081.4(LYST):c.7627+6A>T	rs749282192	0.00008
NM_000081.4(LYST):c.9520G>A (p.Val3174Ile)	rs199672291	0.00008
NM_000081.4(LYST):c.3030A>G (p.Gly1010=)	rs751511204	0.00006
NM_000081.4(LYST):c.3834G>A (p.Leu1278=)	rs148542548	0.00006
NM_000081.4(LYST):c.4983G>A (p.Leu1661=)	rs1482156206	0.00006
NM_000081.4(LYST):c.5635-4A>G	rs754201076	0.00006
NM_000081.4(LYST):c.7911G>A (p.Thr2637=)	rs140229368	0.00006
NM_000081.4(LYST):c.4705A>C (p.Asn1569His)	rs767687843	0.00004
NM_000081.4(LYST):c.10758C>T (p.Cys3586=)	rs145136281	0.00003
NM_000081.4(LYST):c.4566A>C (p.Ala1522=)	rs142344106	0.00003
NM_000081.4(LYST):c.4632C>T (p.Ser1544=)	rs373930104	0.00003
NM_000081.4(LYST):c.2724C>T (p.Cys908=)	rs201440611	0.00001
NM_000081.4(LYST):c.10341G>A (p.Glu3447=)
NM_000081.4(LYST):c.10740G>A (p.Leu3580=)
NM_000081.4(LYST):c.11038+11T>C
NM_000081.4(LYST):c.11076C>T (p.Asn3692=)
NM_000081.4(LYST):c.11229A>G (p.Arg3743=)
NM_000081.4(LYST):c.1664A>C (p.His555Pro)
NM_000081.4(LYST):c.1722A>G (p.Leu574=)
NM_000081.4(LYST):c.1725G>A (p.Ser575=)
NM_000081.4(LYST):c.244C>T (p.Leu82=)
NM_000081.4(LYST):c.285T>C (p.Asp95=)
NM_000081.4(LYST):c.345A>G (p.Gln115=)
NM_000081.4(LYST):c.3712+12T>C
NM_000081.4(LYST):c.372A>G (p.Leu124=)
NM_000081.4(LYST):c.4053A>G (p.Ser1351=)
NM_000081.4(LYST):c.5461-14A>T
NM_000081.4(LYST):c.5461-3dup	rs557545474
NM_000081.4(LYST):c.5583T>C (p.Ile1861=)
NM_000081.4(LYST):c.5634+11A>G
NM_000081.4(LYST):c.5674A>G (p.Met1892Val)
NM_000081.4(LYST):c.6673C>T (p.Arg2225Cys)
NM_000081.4(LYST):c.6744A>G (p.Leu2248=)
NM_000081.4(LYST):c.8152-8G>A
NM_000081.4(LYST):c.8742A>G (p.Lys2914=)
NM_000081.4(LYST):c.9162+15A>G
NM_000081.4(LYST):c.9244T>C (p.Leu3082=)

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