ClinVar Miner

Variants in gene MET with conflicting interpretations

Y axis minimum submission review status: Y axis collection method:
X axis minimum submission review status: X axis collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than two submissions, it may have multiple conflicts and therefore be counted in more than one conflict column. If this is the case, the "Variants with any kind of conflict" cell will be less than the sum of the conflicted variants cells to its left.

Variants with only 1 submission Variants with at least 2 submissions and no conflicts Variants with a synonymous conflict
(e.g. benign vs non-pathogenic)
Variants with a confidence conflict
(e.g. benign vs likely benign)
Variants with a benign or likely benign vs uncertain conflict Variants with a category conflict
(e.g. benign vs affects)
Variants with a clinically significant conflict
(e.g. benign vs pathogenic)
Variants with any kind of conflict
497 118 12 35 35 0 3 67

Significance breakdown #

In the table below, cells that correspond to a term paired with itself represent synonymous conflicts, i.e. variants that have been annotated with different terms that map to the same standard term. To compare the terms that were actually submitted, check the box in the filters section at the top of this page.

pathogenic likely pathogenic uncertain significance likely benign benign
pathogenic 0 5 0 0 0
likely pathogenic 5 0 3 2 2
uncertain significance 0 3 9 35 10
likely benign 0 2 35 0 30
benign 0 2 10 30 3

All variants with conflicting interpretations #

Total variants: 67
Download table as spreadsheet
HGVS dbSNP
NM_000245.3(MET):c.1019A>G (p.Asp340Gly) rs200690492
NM_000245.3(MET):c.110T>C (p.Val37Ala) rs201315884
NM_000245.3(MET):c.1124A>G (p.Asn375Ser) rs33917957
NM_000245.3(MET):c.1180C>A (p.His394Asn) rs201628326
NM_000245.3(MET):c.1810C>G (p.Leu604Val) rs201861645
NM_000245.3(MET):c.2383A>G (p.Asn795Asp) rs200633053
NM_000245.3(MET):c.2908C>T (p.Arg970Cys) rs34589476
NM_000245.3(MET):c.2975C>T (p.Thr992Ile) rs56391007
NM_000245.3(MET):c.3356G>C (p.Gly1119Ala) rs201037977
NM_000245.3(MET):c.4151C>G (p.Ala1384Gly) rs202166889
NM_000245.3(MET):c.504G>T (p.Glu168Asp) rs55985569
NM_000245.3(MET):c.607T>A (p.Ser203Thr) rs200861145
NM_000245.3(MET):c.71G>A (p.Gly24Glu) rs180985111
NM_000245.3(MET):c.948A>G (p.Ile316Met) rs35225896
NM_000245.3(MET):c.967A>G (p.Ser323Gly) rs201467281
NM_001127500.1(MET):c.1039G>A (p.Ala347Thr) rs200074800
NM_001127500.1(MET):c.144G>A (p.Ala48=) rs11762213
NM_001127500.1(MET):c.3335A>G (p.His1112Arg) rs121913243
NM_001127500.1(MET):c.654G>A (p.Arg218=) rs35284565
NM_001127500.2(MET):c.-14-4G>A rs144126521
NM_001127500.2(MET):c.103A>T (p.Met35Leu) rs375353223
NM_001127500.2(MET):c.1076G>A (p.Arg359Gln) rs201274041
NM_001127500.2(MET):c.1085T>C (p.Met362Thr) rs77523018
NM_001127500.2(MET):c.1099A>G (p.Ile367Val) rs774146015
NM_001127500.2(MET):c.1191C>T (p.Cys397=) rs35763409
NM_001127500.2(MET):c.1263C>T (p.Thr421=) rs45499391
NM_001127500.2(MET):c.12C>T (p.Pro4=) rs772251895
NM_001127500.2(MET):c.1715G>A (p.Ser572Asn) rs199771406
NM_001127500.2(MET):c.1723C>A (p.Leu575Ile) rs587778445
NM_001127500.2(MET):c.1863-5dupT rs766900241
NM_001127500.2(MET):c.1932C>T (p.His644=) rs45520237
NM_001127500.2(MET):c.2110A>G (p.Asn704Asp) rs373030463
NM_001127500.2(MET):c.2198C>T (p.Thr733Ile) rs201271860
NM_001127500.2(MET):c.2332A>G (p.Ile778Val) rs786202191
NM_001127500.2(MET):c.2372C>T (p.Pro791Leu) rs771333219
NM_001127500.2(MET):c.2488C>G (p.Gln830Glu) rs398123568
NM_001127500.2(MET):c.2638-7del rs587780736
NM_001127500.2(MET):c.2638-9T>C rs74994656
NM_001127500.2(MET):c.2712C>T (p.His904=) rs748950533
NM_001127500.2(MET):c.2716C>T (p.His906Tyr) rs115574135
NM_001127500.2(MET):c.2769C>T (p.Ser923=) rs45572835
NM_001127500.2(MET):c.3119G>A (p.Arg1040Gln) rs45612435
NM_001127500.2(MET):c.3271C>T (p.Pro1091Ser) rs398123569
NM_001127500.2(MET):c.3272C>T (p.Pro1091Leu) rs370529693
NM_001127500.2(MET):c.3328G>A (p.Val1110Ile) rs786202724
NM_001127500.2(MET):c.3575A>G (p.His1192Arg) rs372830789
NM_001127500.2(MET):c.3576T>C (p.His1192=) rs146651797
NM_001127500.2(MET):c.3603C>T (p.Gly1201=) rs371165052
NM_001127500.2(MET):c.3736G>A (p.Asp1246Asn) rs121913671
NM_001127500.2(MET):c.3742T>C (p.Tyr1248His) rs121913247
NM_001127500.2(MET):c.3743A>G (p.Tyr1248Cys) rs121913246
NM_001127500.2(MET):c.3804G>A (p.Met1268Ile) rs121913676
NM_001127500.2(MET):c.3864C>T (p.Gly1288=) rs200865810
NM_001127500.2(MET):c.390C>T (p.Leu130=) rs150588908
NM_001127500.2(MET):c.4128C>T (p.Asn1376=) rs772860611
NM_001127500.2(MET):c.4141G>A (p.Ala1381Thr) rs45578433
NM_001127500.2(MET):c.4159T>C (p.Leu1387=) rs45575438
NM_001127500.2(MET):c.4171G>C (p.Asp1391His) rs398123570
NM_001127500.2(MET):c.467C>T (p.Ser156Leu) rs56311081
NM_001127500.2(MET):c.468G>A (p.Ser156=) rs576502224
NM_001127500.2(MET):c.632T>G (p.Leu211Trp) rs45483396
NM_001127500.2(MET):c.639G>A (p.Ser213=) rs587780738
NM_001127500.2(MET):c.690G>A (p.Thr230=) rs200138253
NM_001127500.2(MET):c.789G>A (p.Thr263=) rs554190225
NM_001127500.2(MET):c.798G>A (p.Arg266=) rs185301166
NM_001127500.2(MET):c.901A>G (p.Thr301Ala) rs201687037
NM_001127500.2(MET):c.959C>T (p.Ala320Val) rs35776110

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