ClinVar Miner

Variants in gene MLH3 with conflicting interpretations "likely benign" and "benign"

Submission 1 (likely benign) minimum review status: Submission 1 (likely benign) method:
Submission 2 (benign) minimum review status: Submission 2 (benign) method:
Gene type:
ClinVar version:
Total variants with conflicting interpretations: 29
Download table as spreadsheet
HGVS dbSNP gnomAD frequency
NM_001040108.2(MLH3):c.2159A>G (p.Tyr720Cys) rs28756988 0.02978
NM_001040108.2(MLH3):c.666G>A (p.Lys222=) rs28756980 0.01977
NM_001040108.2(MLH3):c.444G>C (p.Val148=) rs11556091 0.01944
NM_001040108.2(MLH3):c.4242+13C>G rs77157930 0.01890
NM_001040108.2(MLH3):c.2533A>G (p.Ser845Gly) rs28756992 0.01483
NM_001040108.2(MLH3):c.691A>C (p.Lys231Gln) rs28756981 0.01348
NM_001040108.2(MLH3):c.1258G>A (p.Val420Ile) rs28756982 0.01142
NM_001040108.2(MLH3):c.2896T>C (p.Ser966Pro) rs17782839 0.01052
NM_001040108.2(MLH3):c.2825C>T (p.Thr942Ile) rs17102999 0.00989
NM_001040108.2(MLH3):c.3570+28A>T rs67547819 0.00949
NM_001040108.2(MLH3):c.8A>G (p.Lys3Arg) rs114829239 0.00905
NM_001040108.2(MLH3):c.1870G>C (p.Glu624Gln) rs28756986 0.00772
NM_001040108.2(MLH3):c.408T>C (p.Asp136=) rs61755655 0.00552
NM_001040108.2(MLH3):c.3217G>A (p.Asp1073Asn) rs28756993 0.00551
NM_001040108.2(MLH3):c.3987+15C>T rs117251698 0.00496
NM_001040108.2(MLH3):c.3315C>A (p.Asp1105Glu) rs28757008 0.00323
NM_001040108.2(MLH3):c.3987+7C>A rs28757028 0.00219
NM_001040108.2(MLH3):c.3644-13C>T rs189760727 0.00199
NM_001040108.2(MLH3):c.2490T>G (p.Phe830Leu) rs114015611 0.00177
NM_001040108.2(MLH3):c.2167G>A (p.Val723Ile) rs28756989 0.00168
NM_001040108.2(MLH3):c.2924A>G (p.Asn975Ser) rs141066164 0.00160
NM_001040108.2(MLH3):c.429G>A (p.Gly143=) rs138943686 0.00160
NM_001040108.2(MLH3):c.3746C>T (p.Ser1249Phe) rs139265757 0.00108
NM_001040108.2(MLH3):c.4351G>A (p.Glu1451Lys) rs28939071 0.00104
NM_001040108.2(MLH3):c.837C>T (p.Cys279=) rs149962294 0.00039
NM_001040108.2(MLH3):c.3280+14A>T rs142042839 0.00019
NM_001040108.2(MLH3):c.3312C>T (p.Ser1104=) rs149369905 0.00006
NM_001040108.2(MLH3):c.3784C>T (p.Pro1262Ser) rs372912259 0.00001
NM_001040108.2(MLH3):c.3570+29AT[10] rs145063005

The information on this website is not intended for direct diagnostic use or medical decision-making without review by a genetics professional. Individuals should not change their health behavior solely on the basis of information contained on this website. Neither the University of Utah nor the National Institutes of Health independently verfies the submitted information. If you have questions about the information contained on this website, please see a health care professional.