ClinVar Miner

Variants in gene MSH3 with conflicting interpretations

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Y axis minimum submission review status: Y axis collection method:
X axis minimum submission review status: X axis collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than two submissions, it may have multiple conflicts and therefore be counted in more than one conflict column. If this is the case, the "Variants with any kind of conflict" cell will be less than the sum of the conflicted variants cells to its left.

Variants with only 1 submission per condition Variants with at least 2 submissions on the same condition and no conflicts Variants with a synonymous conflict
(e.g. benign vs non-pathogenic)
Variants with a confidence conflict
(e.g. benign vs likely benign)
Variants with a benign or likely benign vs uncertain conflict Variants with a category conflict
(e.g. benign vs affects)
Variants with a clinically significant conflict
(e.g. benign vs pathogenic)
Variants with any conflict
3535 287 0 37 52 0 2 84

Significance breakdown #

In the table below, cells that correspond to a term paired with itself represent synonymous conflicts, i.e. variants that have been annotated with different terms that map to the same standard term. To compare the terms that were actually submitted, check the box in the filters section at the top of this page.

pathogenic likely pathogenic uncertain significance likely benign benign
pathogenic 0 20 1 0 0
likely pathogenic 20 0 1 0 0
uncertain significance 1 1 0 48 11
likely benign 0 0 48 0 17
benign 0 0 11 17 0

All variants with conflicting interpretations #

Total variants: 84
Download table as spreadsheet
HGVS dbSNP gnomAD frequency
NM_002439.5(MSH3):c.1567G>A (p.Glu523Lys) rs34058399 0.00789
NM_002439.5(MSH3):c.2254-19T>G rs41562717 0.00405
NM_002439.5(MSH3):c.1896+18C>T rs150904071 0.00330
NM_002439.5(MSH3):c.2511G>A (p.Leu837=) rs149628160 0.00270
NM_002439.5(MSH3):c.2732T>G (p.Leu911Trp) rs41545019 0.00233
NM_002439.5(MSH3):c.1571A>C (p.Asn524Thr) rs55724159 0.00220
NM_002439.5(MSH3):c.1469C>A (p.Ser490Tyr) rs76249824 0.00201
NM_002439.5(MSH3):c.1887T>C (p.Tyr629=) rs139201310 0.00193
NM_002439.5(MSH3):c.2480A>G (p.His827Arg) rs138339194 0.00191
NM_002439.5(MSH3):c.1897-12T>A rs56244266 0.00171
NM_002439.5(MSH3):c.1992G>A (p.Gln664=) rs144019582 0.00143
NM_002439.5(MSH3):c.792+8G>A rs147777411 0.00136
NM_002439.5(MSH3):c.1794G>A (p.Ser598=) rs61753791 0.00130
NM_002439.5(MSH3):c.2740A>G (p.Ile914Val) rs148633216 0.00130
NM_002439.5(MSH3):c.1313C>T (p.Ala438Val) rs35121792 0.00128
NM_002439.5(MSH3):c.1522A>G (p.Lys508Glu) rs146768828 0.00112
NM_002439.5(MSH3):c.2041C>T (p.Pro681Ser) rs115198722 0.00112
NM_002439.5(MSH3):c.2318+11A>G rs200378976 0.00111
NM_002439.5(MSH3):c.1160T>A (p.Phe387Tyr) rs140543135 0.00105
NM_002439.5(MSH3):c.1453+15T>C rs200717987 0.00096
NM_002439.5(MSH3):c.2005C>T (p.Arg669Trp) rs35045151 0.00089
NM_002439.5(MSH3):c.2262A>G (p.Ile754Met) rs200819607 0.00028
NM_002439.5(MSH3):c.356C>T (p.Ser119Phe) rs144607594 0.00028
NM_002439.5(MSH3):c.2685C>T (p.Thr895=) rs61753792 0.00024
NM_002439.5(MSH3):c.2438A>G (p.Lys813Arg) rs150446804 0.00022
NM_002439.5(MSH3):c.1174-12A>G rs202083881 0.00021
NM_002439.5(MSH3):c.3027C>G (p.Thr1009=) rs145319344 0.00019
NM_002439.5(MSH3):c.3174A>G (p.Gln1058=) rs758314489 0.00016
NM_002439.5(MSH3):c.1177G>A (p.Val393Met) rs761779919 0.00013
NM_002439.5(MSH3):c.1194C>T (p.Gly398=) rs141118996 0.00013
NM_002439.5(MSH3):c.562C>T (p.Arg188Cys) rs147289289 0.00013
NM_002439.5(MSH3):c.3181A>G (p.Arg1061Gly) rs746782115 0.00012
NM_002439.5(MSH3):c.3000T>G (p.Asp1000Glu) rs139205893 0.00010
NM_002439.5(MSH3):c.316C>G (p.Gln106Glu) rs149350323 0.00010
NM_002439.5(MSH3):c.2229A>G (p.Gln743=) rs142338243 0.00008
NM_002439.5(MSH3):c.1258A>G (p.Ser420Gly) rs55660516 0.00006
NM_002439.5(MSH3):c.2125T>C (p.Phe709Leu) rs1805354 0.00005
NM_002439.5(MSH3):c.1341-1G>T rs61754780 0.00004
NM_002439.5(MSH3):c.1361G>A (p.Arg454Gln) rs144798521 0.00004
NM_002439.5(MSH3):c.1653+4A>G rs373786812 0.00004
NM_002439.5(MSH3):c.1896A>G (p.Lys632=) rs201737845 0.00004
NM_002439.5(MSH3):c.2085A>G (p.Lys695=) rs777245977 0.00004
NM_002439.5(MSH3):c.3130+4T>G rs764306633 0.00004
NM_002439.5(MSH3):c.439C>T (p.Pro147Ser) rs977366961 0.00004
NM_002439.5(MSH3):c.517A>G (p.Ser173Gly) rs750311213 0.00004
NM_002439.5(MSH3):c.574C>T (p.Gln192Ter) rs374133543 0.00004
NM_002439.5(MSH3):c.2436-1G>A rs200639359 0.00003
NM_002439.5(MSH3):c.582C>G (p.Asp194Glu) rs749446559 0.00003
NM_002439.5(MSH3):c.359-17C>G rs761027175 0.00002
NM_002439.5(MSH3):c.1028-5A>T rs774961818 0.00001
NM_002439.5(MSH3):c.1144A>T (p.Lys382Ter) rs139170496 0.00001
NM_002439.5(MSH3):c.1480A>G (p.Asn494Asp) rs778563277 0.00001
NM_002439.5(MSH3):c.1937A>G (p.Tyr646Cys) rs772586624 0.00001
NM_002439.5(MSH3):c.2212A>T (p.Lys738Ter) rs1580035037 0.00001
NM_002439.5(MSH3):c.2370A>G (p.Arg790=) rs1278142628 0.00001
NM_002439.5(MSH3):c.2436-3T>C rs374901174 0.00001
NM_002439.5(MSH3):c.2655A>G (p.Ser885=) rs192592067 0.00001
NM_002439.5(MSH3):c.2985G>A (p.Glu995=) rs1324032838 0.00001
NM_002439.5(MSH3):c.563G>A (p.Arg188His) rs572193350 0.00001
NM_002439.5(MSH3):c.580-5G>T rs770150309 0.00001
NM_002439.5(MSH3):c.909G>C (p.Lys303Asn) rs757164724 0.00001
NM_002439.5(MSH3):c.1060dup (p.Val354fs) rs1580553669
NM_002439.5(MSH3):c.1148del (p.Lys383fs) rs587776701
NM_002439.5(MSH3):c.1203G>T (p.Val401=) rs1414371236
NM_002439.5(MSH3):c.1256C>G (p.Ser419Ter) rs578113271
NM_002439.5(MSH3):c.1310_1311del (p.Glu437fs) rs757194485
NM_002439.5(MSH3):c.1332A>G (p.Thr444=) rs1252609685
NM_002439.5(MSH3):c.1421_1422del (p.Glu474fs) rs778610412
NM_002439.5(MSH3):c.1534G>T (p.Glu512Ter) rs1379605717
NM_002439.5(MSH3):c.1625dup (p.Leu542fs) rs775863622
NM_002439.5(MSH3):c.1686G>A (p.Trp562Ter) rs1395288001
NM_002439.5(MSH3):c.1736G>A (p.Trp579Ter) rs2112868963
NM_002439.5(MSH3):c.1764-9_1764-8del rs41559616
NM_002439.5(MSH3):c.1911G>A (p.Glu637=) rs1005120343
NM_002439.5(MSH3):c.2227_2228del (p.Gln743fs) rs1371600437
NM_002439.5(MSH3):c.2319-1G>A rs866260675
NM_002439.5(MSH3):c.2469A>G (p.Lys823=) rs2112020238
NM_002439.5(MSH3):c.2586A>T (p.Gly862=) rs1744630430
NM_002439.5(MSH3):c.2686G>T (p.Gly896Ter) rs777054839
NM_002439.5(MSH3):c.2760del (p.Tyr921fs) rs751326348
NM_002439.5(MSH3):c.3003G>A (p.Val1001=)
NM_002439.5(MSH3):c.316C>T (p.Gln106Ter) rs149350323
NM_002439.5(MSH3):c.586del (p.Thr196fs) rs771721952
NM_002439.5(MSH3):c.763A>T (p.Lys255Ter)

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