Variants in gene MTHFR with conflicting interpretations "uncertain significance" and "likely benign"

Submission 1 (uncertain significance) minimum review status:		Submission 1 (uncertain significance) method:
Submission 2 (likely benign) minimum review status:		Submission 2 (likely benign) method:
Gene type: Distinguish antisense genes from sense genes
Show significances as they were submitted (without aggregation into standard terms)
		ClinVar version:

Total variants with conflicting interpretations: 14

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HGVS	dbSNP	gnomAD frequency
NM_005957.5(MTHFR):c.1555C>T (p.Arg519Cys)	rs45496998	0.00176
NM_005957.5(MTHFR):c.1761C>T (p.Ala587=)	rs115049252	0.00145
NM_005957.5(MTHFR):c.708C>T (p.Phe236=)	rs34279942	0.00134
NM_005957.5(MTHFR):c.1556G>T (p.Arg519Leu)	rs45449298	0.00118
NM_005957.5(MTHFR):c.1625A>C (p.Asn542Thr)	rs145641996	0.00073
NM_005957.5(MTHFR):c.667G>A (p.Asp223Asn)	rs150847674	0.00068
NM_005957.5(MTHFR):c.1392C>T (p.Thr464=)	rs79157191	0.00064
NM_005957.5(MTHFR):c.1032-6A>G	rs2066464	0.00061
NM_005957.5(MTHFR):c.1719C>T (p.Thr573=)	rs149585376	0.00029
NM_005957.5(MTHFR):c.903G>A (p.Leu301=)	rs147979890	0.00014
NM_005957.5(MTHFR):c.90G>A (p.Ser30=)	rs765167328	0.00004
NM_005957.5(MTHFR):c.1002G>A (p.Lys334=)	rs147727428	0.00001
NM_005957.5(MTHFR):c.1408_1409delinsCT (p.Glu470Leu)	rs886043349
NM_005957.5(MTHFR):c.469C>A (p.Arg157=)	rs776195746

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