Variants in gene MTHFR with conflicting interpretations "uncertain significance" and "pathogenic"

Submission 1 (uncertain significance) minimum review status:		Submission 1 (uncertain significance) method:
Submission 2 (pathogenic) minimum review status:		Submission 2 (pathogenic) method:
Gene type: Distinguish antisense genes from sense genes
Show significances as they were submitted (without aggregation into standard terms)
		ClinVar version:

Total variants with conflicting interpretations: 16

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HGVS	dbSNP	gnomAD frequency
NM_005957.5(MTHFR):c.665C>T (p.Ala222Val)	rs1801133	0.27446
NM_005957.5(MTHFR):c.3G>C (p.Met1Ile)	rs373076763	0.00021
NM_005957.5(MTHFR):c.1004G>A (p.Arg335His)	rs543016186	0.00004
NM_005957.5(MTHFR):c.1129C>T (p.Arg377Cys)	rs121434296	0.00004
NM_005957.5(MTHFR):c.1743G>A (p.Met581Ile)	rs45590836	0.00003
NM_005957.5(MTHFR):c.1088G>A (p.Arg363His)	rs786204023	0.00001
NM_005957.5(MTHFR):c.416C>T (p.Thr139Met)	rs1057519360	0.00001
NM_005957.5(MTHFR):c.680C>T (p.Thr227Met)	rs748571395	0.00001
NM_005957.5(MTHFR):c.767T>A (p.Ile256Asn)	rs373398993	0.00001
NM_005957.5(MTHFR):c.-13-28_-13-27del	rs1553188112
NM_005957.5(MTHFR):c.1060C>T (p.His354Tyr)	rs786204022
NM_005957.5(MTHFR):c.1228_1242del (p.Ser410_Lys414del)	rs1297161027
NM_005957.5(MTHFR):c.1606G>T (p.Val536Phe)	rs786204028
NM_005957.5(MTHFR):c.1793T>C (p.Leu598Pro)	rs786204034
NM_005957.5(MTHFR):c.643_645del (p.Lys215del)	rs746353274
NM_005957.5(MTHFR):c.760C>T (p.Pro254Ser)	rs786204017

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