Variants in gene NOTCH3 with conflicting interpretations "likely pathogenic" and "uncertain significance"

Submission 1 (likely pathogenic) minimum review status:		Submission 1 (likely pathogenic) method:
Submission 2 (uncertain significance) minimum review status:		Submission 2 (uncertain significance) method:
Gene type: Distinguish antisense genes from sense genes
Show significances as they were submitted (without aggregation into standard terms)
		ClinVar version:

Total variants with conflicting interpretations: 16

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HGVS	dbSNP	gnomAD frequency
NM_000435.3(NOTCH3):c.3664T>G (p.Cys1222Gly)	rs199638166	0.00011
NM_000435.3(NOTCH3):c.2149C>T (p.Arg717Cys)	rs144163298	0.00004
NM_000435.3(NOTCH3):c.2038C>T (p.Arg680Cys)	rs1250956327	0.00001
NM_000435.3(NOTCH3):c.2182C>T (p.Arg728Cys)	rs1057519101	0.00001
NM_000435.3(NOTCH3):c.3356G>A (p.Cys1119Tyr)	rs1266914122	0.00001
NM_000435.3(NOTCH3):c.1305T>G (p.Cys435Trp)	rs2046907170
NM_000435.3(NOTCH3):c.1364G>A (p.Cys455Tyr)	rs886041513
NM_000435.3(NOTCH3):c.1759C>T (p.Arg587Cys)	rs754554486
NM_000435.3(NOTCH3):c.1903C>T (p.Arg635Cys)	rs753801611
NM_000435.3(NOTCH3):c.208G>T (p.Gly70Cys)
NM_000435.3(NOTCH3):c.239A>G (p.Asp80Gly)	rs1599395616
NM_000435.3(NOTCH3):c.3084G>C (p.Trp1028Cys)	rs2046832726
NM_000435.3(NOTCH3):c.3782G>A (p.Cys1261Tyr)
NM_000435.3(NOTCH3):c.3893G>T (p.Cys1298Phe)	rs2046807248
NM_000435.3(NOTCH3):c.3944G>A (p.Cys1315Tyr)	rs1432396805
NM_000435.3(NOTCH3):c.719G>A (p.Cys240Tyr)	rs1599394351

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