Variants in gene NOTCH3 with conflicting interpretations "uncertain significance" and "benign"

Submission 1 (uncertain significance) minimum review status:		Submission 1 (uncertain significance) method:
Submission 2 (benign) minimum review status:		Submission 2 (benign) method:
Gene type: Distinguish antisense genes from sense genes
Show significances as they were submitted (without aggregation into standard terms)
		ClinVar version:

Total variants with conflicting interpretations: 13

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HGVS	dbSNP	gnomAD frequency
NM_000435.3(NOTCH3):c.4044C>T (p.Gly1348=)	rs78926093	0.00784
NM_000435.3(NOTCH3):c.3704A>T (p.His1235Leu)	rs55882518	0.00433
NM_000435.3(NOTCH3):c.3691C>T (p.Arg1231Cys)	rs201680145	0.00089
NM_000435.3(NOTCH3):c.1931T>A (p.Val644Asp)	rs148046938	0.00063
NM_000435.3(NOTCH3):c.3658C>T (p.Arg1220Trp)	rs115872852	0.00036
NM_000435.3(NOTCH3):c.3170C>T (p.Ala1057Val)	rs368146879	0.00026
NM_000435.3(NOTCH3):c.2183G>A (p.Arg728His)	rs144935367	0.00024
NM_000435.3(NOTCH3):c.2437G>A (p.Glu813Lys)	rs375873637	0.00020
NM_000435.3(NOTCH3):c.1690G>A (p.Ala564Thr)	rs374767079	0.00013
NM_000435.3(NOTCH3):c.3569G>A (p.Arg1190His)	rs372241697	0.00013
NM_000435.3(NOTCH3):c.6809C>T (p.Thr2270Met)	rs148716935	0.00011
NM_000435.3(NOTCH3):c.487C>T (p.Arg163Trp)	rs367707092	0.00006
NM_000435.3(NOTCH3):c.1678G>A (p.Val560Met)	rs200160665	0.00004

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