Variants in gene OTOF with conflicting interpretations "likely benign" and "uncertain significance"

Submission 1 (likely benign) minimum review status:		Submission 1 (likely benign) method:
Submission 2 (uncertain significance) minimum review status:		Submission 2 (uncertain significance) method:
Gene type: Distinguish antisense genes from sense genes
Show significances as they were submitted (without aggregation into standard terms)
		ClinVar version:

Total variants with conflicting interpretations: 90

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HGVS	dbSNP	gnomAD frequency
NM_194248.3(OTOF):c.2215-80T>C	rs143141993	0.00268
NM_194248.3(OTOF):c.245G>A (p.Arg82His)	rs149766574	0.00237
NM_194248.3(OTOF):c.5742G>A (p.Leu1914=)	rs141235641	0.00191
NM_194248.3(OTOF):c.2375G>A (p.Arg792Gln)	rs144800506	0.00170
NM_194248.3(OTOF):c.339C>T (p.Cys113=)	rs139098225	0.00123
NM_194248.3(OTOF):c.2381G>A (p.Arg794His)	rs80356592	0.00122
NM_194248.3(OTOF):c.3917A>C (p.Lys1306Thr)	rs62641623	0.00103
NM_194248.3(OTOF):c.2123G>A (p.Arg708Gln)	rs145019640	0.00098
NM_194248.3(OTOF):c.3966C>G (p.Asp1322Glu)	rs80356576	0.00096
NM_194248.3(OTOF):c.1530C>T (p.Ile510=)	rs150452778	0.00093
NM_194248.3(OTOF):c.1630C>T (p.Arg544Cys)	rs139954767	0.00093
NM_194248.3(OTOF):c.5394C>T (p.Asp1798=)	rs111033366	0.00091
NM_194248.3(OTOF):c.3385G>A (p.Val1129Met)	rs138249243	0.00089
NM_194248.3(OTOF):c.2908C>T (p.Arg970Cys)	rs140613217	0.00081
NM_194248.3(OTOF):c.4463A>T (p.Asp1488Val)	rs142284613	0.00081
NM_194248.3(OTOF):c.1910T>C (p.Ile637Thr)	rs111033351	0.00076
NM_194248.3(OTOF):c.4483C>A (p.Arg1495=)	rs147321712	0.00048
NM_194248.3(OTOF):c.5829C>T (p.Ser1943=)	rs151005752	0.00046
NM_194248.3(OTOF):c.3706C>G (p.Arg1236Gly)	rs199904558	0.00045
NM_194248.3(OTOF):c.4548C>T (p.Tyr1516=)	rs139525746	0.00040
NM_194248.3(OTOF):c.3332C>T (p.Pro1111Leu)	rs141972928	0.00038
NM_194248.3(OTOF):c.1640C>T (p.Thr547Met)	rs200191563	0.00036
NM_194248.3(OTOF):c.5292-9C>T	rs372713647	0.00036
NM_194248.3(OTOF):c.748C>T (p.Arg250Trp)	rs373680242	0.00036
NM_194248.3(OTOF):c.2650G>A (p.Ala884Thr)	rs144594692	0.00035
NM_194248.3(OTOF):c.898-6C>G	rs199687628	0.00035
NM_194248.3(OTOF):c.4023+1G>A	rs186810296	0.00031
NM_194248.3(OTOF):c.1135G>A (p.Val379Met)	rs141111646	0.00030
NM_194248.3(OTOF):c.3939G>A (p.Ala1313=)	rs149566576	0.00027
NM_194248.3(OTOF):c.154G>A (p.Val52Met)	rs199992845	0.00026
NM_194248.3(OTOF):c.1960C>T (p.Arg654Trp)	rs144259658	0.00026
NM_194248.3(OTOF):c.152C>T (p.Pro51Leu)	rs150132765	0.00025
NM_194248.3(OTOF):c.327+5G>T	rs370643920	0.00024
NM_194248.3(OTOF):c.327+10C>A	rs377042002	0.00021
NM_194248.3(OTOF):c.2498A>T (p.Gln833Leu)	rs191568463	0.00019
NM_194248.3(OTOF):c.2848G>A (p.Val950Ile)	rs199613764	0.00019
NM_194248.3(OTOF):c.4454C>T (p.Pro1485Leu)	rs200699092	0.00018
NM_194248.3(OTOF):c.2590C>T (p.Arg864Cys)	rs150070091	0.00016
NM_194248.3(OTOF):c.4363-6G>A	rs199567872	0.00015
NM_194248.3(OTOF):c.446C>T (p.Thr149Met)	rs140454738	0.00015
NM_194248.3(OTOF):c.2180A>G (p.Asn727Ser)	rs200654171	0.00012
NM_194248.3(OTOF):c.2523+5G>A	rs201745796	0.00012
NM_194248.3(OTOF):c.377G>A (p.Gly126Asp)	rs187033414	0.00011
NM_194248.3(OTOF):c.4951G>A (p.Asp1651Asn)	rs139201321	0.00011
NM_194248.3(OTOF):c.1732G>C (p.Val578Leu)	rs144907002	0.00010
NM_194248.3(OTOF):c.4642G>A (p.Glu1548Lys)	rs146982209	0.00010
NM_194248.3(OTOF):c.337T>C (p.Cys113Arg)	rs146615166	0.00009
NM_194248.3(OTOF):c.3746G>A (p.Arg1249Gln)	rs200312028	0.00009
NM_194248.3(OTOF):c.4559G>A (p.Arg1520Gln)	rs80356601	0.00009
NM_194248.3(OTOF):c.4820G>A (p.Arg1607Gln)	rs141800430	0.00009
NM_194248.3(OTOF):c.5623G>A (p.Val1875Met)	rs370691004	0.00008
NM_194248.3(OTOF):c.843C>T (p.Asp281=)	rs368728682	0.00008
NM_194248.3(OTOF):c.2516C>T (p.Ala839Val)	rs201246660	0.00007
NM_194248.3(OTOF):c.2359C>T (p.Arg787Cys)	rs574277214	0.00006
NM_194248.3(OTOF):c.2075G>A (p.Arg692Gln)	rs147978393	0.00005
NM_194248.3(OTOF):c.2567A>T (p.Asn856Ile)	rs752804141	0.00005
NM_194248.3(OTOF):c.3865-12G>A	rs374902867	0.00005
NM_194248.3(OTOF):c.302T>C (p.Ile101Thr)	rs754508360	0.00004
NM_194248.3(OTOF):c.3637G>A (p.Gly1213Ser)	rs140023414	0.00004
NM_194248.3(OTOF):c.3707G>A (p.Arg1236His)	rs368633281	0.00004
NM_194248.3(OTOF):c.4375G>A (p.Val1459Met)	rs749384668	0.00004
NM_194248.3(OTOF):c.1699G>A (p.Ala567Thr)	rs771560305	0.00003
NM_194248.3(OTOF):c.1713G>A (p.Leu571=)	rs397517935	0.00003
NM_194248.3(OTOF):c.2147G>A (p.Ser716Asn)	rs147657016	0.00003
NM_194248.3(OTOF):c.2465G>A (p.Arg822Gln)	rs373681505	0.00003
NM_194248.3(OTOF):c.40C>T (p.Arg14Trp)	rs774530840	0.00003
NM_194248.3(OTOF):c.4186G>A (p.Glu1396Lys)	rs745399096	0.00003
NM_194248.3(OTOF):c.4783G>A (p.Ala1595Thr)	rs772763082	0.00003
NM_194248.3(OTOF):c.4922G>A (p.Arg1641His)	rs200283244	0.00003
NM_194248.3(OTOF):c.3226T>C (p.Tyr1076His)	rs150782952	0.00002
NM_194248.3(OTOF):c.322A>G (p.Ile108Val)	rs727505189	0.00002
NM_194248.3(OTOF):c.55C>T (p.Arg19Trp)	rs727504985	0.00002
NM_194248.3(OTOF):c.222C>G (p.Ser74Arg)	rs764474318	0.00001
NM_194248.3(OTOF):c.251T>C (p.Val84Ala)	rs727505096	0.00001
NM_194248.3(OTOF):c.2690G>A (p.Arg897Gln)	rs760896684	0.00001
NM_194248.3(OTOF):c.4474G>A (p.Val1492Met)	rs368297003	0.00001
NM_194248.3(OTOF):c.5553G>C (p.Leu1851=)	rs747844017	0.00001
NM_194248.3(OTOF):c.5632G>A (p.Val1878Met)	rs757360892	0.00001
NM_194248.3(OTOF):c.5712+6C>G	rs200435099	0.00001
NM_194248.3(OTOF):c.1553G>T (p.Arg518Leu)	rs150090360
NM_194248.3(OTOF):c.2436G>A (p.Leu812=)	rs2148051340
NM_194248.3(OTOF):c.2457C>T (p.His819=)
NM_194248.3(OTOF):c.2765G>T (p.Arg922Leu)
NM_194248.3(OTOF):c.3720C>T (p.Ser1240=)
NM_194248.3(OTOF):c.4417G>A (p.Gly1473Ser)
NM_194248.3(OTOF):c.481C>T (p.Arg161Trp)	rs377378925
NM_194248.3(OTOF):c.5193-3del
NM_194248.3(OTOF):c.5475C>A (p.Pro1825=)	rs760178516
NM_194248.3(OTOF):c.5479C>A (p.Arg1827=)	rs142748621
NM_194248.3(OTOF):c.5479C>T (p.Arg1827Trp)	rs142748621

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