Variants in gene PCSK9 with conflicting interpretations "pathogenic" and "uncertain significance"

Submission 1 (pathogenic) minimum review status:		Submission 1 (pathogenic) method:
Submission 2 (uncertain significance) minimum review status:		Submission 2 (uncertain significance) method:
Gene type: Distinguish antisense genes from sense genes
Show significances as they were submitted (without aggregation into standard terms)
		ClinVar version:

Total variants with conflicting interpretations: 21

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HGVS	dbSNP	gnomAD frequency
NM_174936.4(PCSK9):c.1274A>G (p.Asn425Ser)	rs28362261	0.00485
NM_174936.4(PCSK9):c.2037C>A (p.Cys679Ter)	rs28362286	0.00262
NM_174936.4(PCSK9):c.1069C>T (p.Arg357Cys)	rs148562777	0.00012
NM_174936.4(PCSK9):c.1487G>A (p.Arg496Gln)	rs139669564	0.00005
NM_174936.4(PCSK9):c.286C>T (p.Arg96Cys)	rs185392267	0.00004
NM_174936.4(PCSK9):c.1426C>T (p.Arg476Cys)	rs761767572	0.00001
NM_174936.4(PCSK9):c.142G>A (p.Glu48Lys)	rs1278890129	0.00001
NM_174936.4(PCSK9):c.1486C>T (p.Arg496Trp)	rs374603772	0.00001
NM_174936.4(PCSK9):c.1503G>A (p.Glu501=)	rs986151799	0.00001
NM_174936.4(PCSK9):c.658G>A (p.Ala220Thr)	rs768795323	0.00001
NM_174936.4(PCSK9):c.1180G>A (p.Gly394Ser)
NM_174936.4(PCSK9):c.1327G>A (p.Ala443Thr)
NM_174936.4(PCSK9):c.1394C>T (p.Ser465Leu)	rs778849441
NM_174936.4(PCSK9):c.1405C>T (p.Arg469Trp)
NM_174936.4(PCSK9):c.158C>G (p.Ala53Gly)	rs11583680
NM_174936.4(PCSK9):c.1856A>C (p.Gln619Pro)
NM_174936.4(PCSK9):c.1979A>C (p.Asp660Ala)
NM_174936.4(PCSK9):c.212C>T (p.Pro71Leu)	rs569379713
NM_174936.4(PCSK9):c.385G>A (p.Asp129Asn)
NM_174936.4(PCSK9):c.644G>A (p.Arg215His)	rs794728683
NM_174936.4(PCSK9):c.94G>A (p.Glu32Lys)

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