ClinVar Miner

Variants in gene PLCB1 with conflicting interpretations

Y axis minimum submission review status: Y axis collection method:
X axis minimum submission review status: X axis collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than two submissions, it may have multiple conflicts and therefore be counted in more than one conflict column. If this is the case, the "Variants with any kind of conflict" cell will be less than the sum of the conflicted variants cells to its left.

Variants with only 1 submission per condition Variants with at least 2 submissions on the same condition and no conflicts Variants with a synonymous conflict
(e.g. benign vs non-pathogenic)
Variants with a confidence conflict
(e.g. benign vs likely benign)
Variants with a benign or likely benign vs uncertain conflict Variants with a category conflict
(e.g. benign vs affects)
Variants with a clinically significant conflict
(e.g. benign vs pathogenic)
Variants with any conflict
436 22 0 18 24 0 0 39

Significance breakdown #

In the table below, cells that correspond to a term paired with itself represent synonymous conflicts, i.e. variants that have been annotated with different terms that map to the same standard term. To compare the terms that were actually submitted, check the box in the filters section at the top of this page.

pathogenic likely pathogenic uncertain significance likely benign benign
pathogenic 0 1 0 0 0
likely pathogenic 1 0 0 0 0
uncertain significance 0 0 0 20 10
likely benign 0 0 20 0 17
benign 0 0 10 17 0

All variants with conflicting interpretations #

Total variants: 39
Download table as spreadsheet
NM_015192.4(PLCB1):c.102C>T (p.Asp34=) rs16994453
NM_015192.4(PLCB1):c.1167+7T>C rs45466294
NM_015192.4(PLCB1):c.1230G>A (p.Ser410=) rs148848282
NM_015192.4(PLCB1):c.1251-4T>G rs2076689
NM_015192.4(PLCB1):c.1469A>G (p.Tyr490Cys) rs45608240
NM_015192.4(PLCB1):c.1491C>T (p.Phe497=) rs145869401
NM_015192.4(PLCB1):c.1581+15C>T rs79284104
NM_015192.4(PLCB1):c.1678+10C>T rs369652433
NM_015192.4(PLCB1):c.1761A>G (p.Val587=) rs143755415
NM_015192.4(PLCB1):c.1764-6G>C rs753832760
NM_015192.4(PLCB1):c.1881G>A (p.Gln627=) rs45492700
NM_015192.4(PLCB1):c.2082G>A (p.Gly694=) rs3761170
NM_015192.4(PLCB1):c.2088C>T (p.Tyr696=) rs189186909
NM_015192.4(PLCB1):c.2112G>A (p.Leu704=)
NM_015192.4(PLCB1):c.2127G>A (p.Arg709=) rs3761169
NM_015192.4(PLCB1):c.2191C>G (p.Pro731Ala) rs61755434
NM_015192.4(PLCB1):c.2199G>A (p.Val733=) rs8118206
NM_015192.4(PLCB1):c.2413+9C>T rs138442805
NM_015192.4(PLCB1):c.2550G>T (p.Glu850Asp) rs141433824
NM_015192.4(PLCB1):c.2565G>A (p.Ala855=) rs2076413
NM_015192.4(PLCB1):c.2570C>T (p.Thr857Met) rs184436336
NM_015192.4(PLCB1):c.2673T>G (p.Pro891=) rs142813933
NM_015192.4(PLCB1):c.2841A>G (p.Glu947=) rs35245209
NM_015192.4(PLCB1):c.288G>T (p.Gly96=) rs200521017
NM_015192.4(PLCB1):c.2967G>A (p.Thr989=) rs45464693
NM_015192.4(PLCB1):c.3116T>C (p.Ile1039Thr) rs75820839
NM_015192.4(PLCB1):c.3120A>G (p.Gln1040=) rs61755436
NM_015192.4(PLCB1):c.3135C>A (p.Val1045=) rs577076166
NM_015192.4(PLCB1):c.3135C>T (p.Val1045=) rs577076166
NM_015192.4(PLCB1):c.3550C>T (p.Leu1184Phe) rs28390202
NM_015192.4(PLCB1):c.3584A>G (p.His1195Arg) rs186429469
NM_015192.4(PLCB1):c.458A>T (p.Glu153Val) rs45496299
NM_015192.4(PLCB1):c.582T>C (p.Leu194=) rs150770296
NM_015192.4(PLCB1):c.627A>G (p.Pro209=) rs151006778
NM_015192.4(PLCB1):c.664C>T (p.Arg222Ter) rs990536521
NM_015192.4(PLCB1):c.714A>C (p.Pro238=) rs147567110
NM_015192.4(PLCB1):c.724G>A (p.Val242Ile) rs200567140
NM_015192.4(PLCB1):c.924A>G (p.Ser308=) rs6056003
NM_015192.4(PLCB1):c.99+8T>C rs6086350

The information on this website is not intended for direct diagnostic use or medical decision-making without review by a genetics professional. Individuals should not change their health behavior solely on the basis of information contained on this website. Neither the University of Utah nor the National Institutes of Health independently verfies the submitted information. If you have questions about the information contained on this website, please see a health care professional.