ClinVar Miner

Variants in gene PRKAR1A with conflicting interpretations

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Y axis minimum submission review status: Y axis collection method:
X axis minimum submission review status: X axis collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than two submissions, it may have multiple conflicts and therefore be counted in more than one conflict column. If this is the case, the "Variants with any kind of conflict" cell will be less than the sum of the conflicted variants cells to its left.

Variants with only 1 submission per condition Variants with at least 2 submissions on the same condition and no conflicts Variants with a synonymous conflict
(e.g. benign vs non-pathogenic)
Variants with a confidence conflict
(e.g. benign vs likely benign)
Variants with a benign or likely benign vs uncertain conflict Variants with a category conflict
(e.g. benign vs affects)
Variants with a clinically significant conflict
(e.g. benign vs pathogenic)
Variants with any conflict
387 9 10 7 6 0 1 23

Significance breakdown #

In the table below, cells that correspond to a term paired with itself represent synonymous conflicts, i.e. variants that have been annotated with different terms that map to the same standard term. To compare the terms that were actually submitted, check the box in the filters section at the top of this page.

pathogenic likely pathogenic uncertain significance likely benign benign
pathogenic 10 1 1 0 0
likely pathogenic 1 0 0 0 0
uncertain significance 1 0 0 5 1
likely benign 0 0 5 0 6
benign 0 0 1 6 0

All variants with conflicting interpretations #

Total variants: 23
Download table as spreadsheet
HGVS dbSNP
NM_002734.5(PRKAR1A):c.-11C>T
NM_002734.5(PRKAR1A):c.491_492del (p.Val164fs) rs281864790
NM_212472.2(PRKAR1A):c.-6-7C>T rs373646911
NM_212472.2(PRKAR1A):c.103A>G (p.Ile35Val) rs377513504
NM_212472.2(PRKAR1A):c.124C>T (p.Arg42Ter) rs281864782
NM_212472.2(PRKAR1A):c.1A>G (p.Met1Val) rs281864779
NM_212472.2(PRKAR1A):c.220C>T (p.Arg74Cys) rs137853303
NM_212472.2(PRKAR1A):c.221G>A (p.Arg74His) rs200069356
NM_212472.2(PRKAR1A):c.286C>T (p.Arg96Ter) rs281864783
NM_212472.2(PRKAR1A):c.309G>A (p.Glu103=) rs746113372
NM_212472.2(PRKAR1A):c.349-5T>C rs1456043929
NM_212472.2(PRKAR1A):c.381T>C (p.Ala127=) rs372669687
NM_212472.2(PRKAR1A):c.489T>C (p.Thr163=) rs143672551
NM_212472.2(PRKAR1A):c.546G>A (p.Thr182=) rs117639566
NM_212472.2(PRKAR1A):c.618_621del (p.Ile206fs) rs281864791
NM_212472.2(PRKAR1A):c.682C>T (p.Arg228Ter) rs281864784
NM_212472.2(PRKAR1A):c.708+1G>T rs281864798
NM_212472.2(PRKAR1A):c.709-7_709-2del rs281864801
NM_212472.2(PRKAR1A):c.762T>C (p.Ser254=) rs753621663
NM_212472.2(PRKAR1A):c.786_787delinsCT (p.Trp262_Glu263delinsCysTer) rs281864785
NM_212472.2(PRKAR1A):c.798G>A (p.Thr266=) rs201774040
NM_212472.2(PRKAR1A):c.87G>A (p.Ala29=) rs3730349
NM_212472.2(PRKAR1A):c.891+3A>G rs281864799

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