ClinVar Miner

Variants in gene combination RAD51D, RAD51L3-RFFL with conflicting interpretations

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Y axis minimum submission review status: Y axis collection method:
X axis minimum submission review status: X axis collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than two submissions, it may have multiple conflicts and therefore be counted in more than one conflict column. If this is the case, the "Variants with any kind of conflict" cell will be less than the sum of the conflicted variants cells to its left.

Variants with only 1 submission per condition Variants with at least 2 submissions on the same condition and no conflicts Variants with a synonymous conflict
(e.g. benign vs non-pathogenic)
Variants with a confidence conflict
(e.g. benign vs likely benign)
Variants with a benign or likely benign vs uncertain conflict Variants with a category conflict
(e.g. benign vs affects)
Variants with a clinically significant conflict
(e.g. benign vs pathogenic)
Variants with any conflict
773 207 0 23 29 3 7 52

Significance breakdown #

In the table below, cells that correspond to a term paired with itself represent synonymous conflicts, i.e. variants that have been annotated with different terms that map to the same standard term. To compare the terms that were actually submitted, check the box in the filters section at the top of this page.

pathogenic likely pathogenic uncertain significance likely benign benign risk factor
pathogenic 0 9 1 0 0 2
likely pathogenic 9 0 7 1 0 0
uncertain significance 1 7 0 27 9 1
likely benign 0 1 27 0 14 0
benign 0 0 9 14 0 0
risk factor 2 0 1 0 0 0

All variants with conflicting interpretations #

Total variants: 52
Download table as spreadsheet
HGVS dbSNP
NM_001142571.2(RAD51D):c.269A>G (p.Asp90Gly) rs180869630
NM_001142571.2(RAD51D):c.726A>G (p.Glu242=) rs114012742
NM_001142571.2(RAD51D):c.755G>A (p.Arg252Gln) rs28363283
NM_001142571.2(RAD51D):c.758A>G (p.Glu253Gly) rs28363284
NM_002878.3(RAD51D):c.137C>G (p.Ser46Cys) rs587780102
NM_002878.3(RAD51D):c.141C>G (p.Tyr47Ter) rs771077929
NM_002878.3(RAD51D):c.145-13G>T rs760867838
NM_002878.3(RAD51D):c.146C>T (p.Ala49Val) rs140317560
NM_002878.3(RAD51D):c.196G>A (p.Val66Met) rs56026142
NM_002878.3(RAD51D):c.1A>G (p.Met1Val) rs561425038
NM_002878.3(RAD51D):c.1A>T (p.Met1Leu) rs561425038
NM_002878.3(RAD51D):c.216C>T (p.Tyr72=) rs148690585
NM_002878.3(RAD51D):c.263+1G>A rs1555570242
NM_002878.3(RAD51D):c.263+7G>T rs56218020
NM_002878.3(RAD51D):c.264-7C>T rs753529790
NM_002878.3(RAD51D):c.26G>C (p.Cys9Ser) rs140825795
NM_002878.3(RAD51D):c.270_271dup (p.Lys91fs) rs753862052
NM_002878.3(RAD51D):c.345+5A>G rs878854562
NM_002878.3(RAD51D):c.355T>C (p.Cys119Arg) rs201313861
NM_002878.3(RAD51D):c.363del (p.Ala122fs) rs730881935
NM_002878.3(RAD51D):c.394G>A (p.Val132Ile) rs201141245
NM_002878.3(RAD51D):c.413A>G (p.Asn138Ser) rs201676898
NM_002878.3(RAD51D):c.451C>T (p.Gln151Ter) rs587781756
NM_002878.3(RAD51D):c.481-5T>G rs374382703
NM_002878.3(RAD51D):c.481-7G>A rs145832514
NM_002878.3(RAD51D):c.481-8C>T rs762247126
NM_002878.3(RAD51D):c.556C>T (p.Arg186Ter) rs387906843
NM_002878.3(RAD51D):c.568G>A (p.Ala190Thr) rs80116829
NM_002878.3(RAD51D):c.620C>G (p.Ser207Trp) rs370228071
NM_002878.3(RAD51D):c.620C>T (p.Ser207Leu) rs370228071
NM_002878.3(RAD51D):c.623dup (p.Thr209fs) rs1555567610
NM_002878.3(RAD51D):c.668-4G>A rs1001440122
NM_002878.3(RAD51D):c.668-4G>T rs1001440122
NM_002878.3(RAD51D):c.715C>T (p.Arg239Trp) rs770250516
NM_002878.3(RAD51D):c.738+3G>A rs751062153
NM_002878.3(RAD51D):c.751A>G (p.Ile251Val) rs540273429
NM_002878.3(RAD51D):c.757C>T (p.Arg253Ter) rs137886232
NM_002878.3(RAD51D):c.771C>T (p.Ser257=) rs146212490
NM_002878.3(RAD51D):c.796C>T (p.Arg266Cys) rs587781813
NM_002878.3(RAD51D):c.81del (p.Val28fs) rs1064793952
NM_002878.3(RAD51D):c.864C>T (p.Gly288=) rs138557828
NM_002878.3(RAD51D):c.865G>A (p.Gly289Ser) rs587782129
NM_002878.3(RAD51D):c.873C>T (p.Arg291=) rs140848654
NM_002878.3(RAD51D):c.904-12TTC[2] rs779850240
NM_002878.3(RAD51D):c.904-2A>T rs1403784434
NM_002878.3(RAD51D):c.904-3C>T rs45478491
NM_002878.3(RAD51D):c.915C>G (p.Phe305Leu) rs1316114457
NM_002878.3(RAD51D):c.919G>A (p.Glu307Lys) rs115031549
NM_002878.3(RAD51D):c.932T>A (p.Ile311Asn) rs145309168
NM_002878.3(RAD51D):c.94_95del (p.Val32fs) rs786203137
NM_002878.3(RAD51D):c.983C>T (p.Thr328Ile) rs138969595
NM_133629.3(RAD51D):c.145-885G>C rs1555568469

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