ClinVar Miner

Variants in gene STAT3 with conflicting interpretations

Y axis minimum submission review status: Y axis collection method:
X axis minimum submission review status: X axis collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than two submissions, it may have multiple conflicts and therefore be counted in more than one conflict column. If this is the case, the "Variants with any kind of conflict" cell will be less than the sum of the conflicted variants cells to its left.

Variants with only 1 submission Variants with at least 2 submissions and no conflicts Variants with a synonymous conflict
(e.g. benign vs non-pathogenic)
Variants with a confidence conflict
(e.g. benign vs likely benign)
Variants with a benign or likely benign vs uncertain conflict Variants with a category conflict
(e.g. benign vs affects)
Variants with a clinically significant conflict
(e.g. benign vs pathogenic)
Variants with any kind of conflict
161 10 5 10 1 0 1 17

Significance breakdown #

In the table below, cells that correspond to a term paired with itself represent synonymous conflicts, i.e. variants that have been annotated with different terms that map to the same standard term. To compare the terms that were actually submitted, check the box in the filters section at the top of this page.

pathogenic likely pathogenic uncertain significance likely benign benign
pathogenic 5 6 1 0 0
likely pathogenic 6 0 0 0 0
uncertain significance 1 0 0 1 0
likely benign 0 0 1 0 4
benign 0 0 0 4 0

All variants with conflicting interpretations #

Total variants: 17
Download table as spreadsheet
NM_139276.2(STAT3):c.1144C>T (p.Arg382Trp) rs113994135
NM_139276.2(STAT3):c.1145G>A (p.Arg382Gln) rs113994136
NM_139276.2(STAT3):c.1243G>A (p.Glu415Lys) rs193922717
NM_139276.2(STAT3):c.1261G>A (p.Gly421Arg) rs869312888
NM_139276.2(STAT3):c.1268G>A (p.Arg423Gln) rs113994137
NM_139276.2(STAT3):c.1329C>T (p.Thr443=) rs147955721
NM_139276.2(STAT3):c.1381G>C (p.Val461Leu) rs149214040
NM_139276.2(STAT3):c.1384_1386GTG[1] (p.Val463del) rs113994138
NM_139276.2(STAT3):c.1654-11C>G rs17882035
NM_139276.2(STAT3):c.1854C>T (p.Gly618=) rs117691970
NM_139276.2(STAT3):c.1909G>A (p.Val637Met) rs113994139
NM_139276.2(STAT3):c.1919A>T (p.Tyr640Phe) rs769031989
NM_139276.2(STAT3):c.1979T>C (p.Met660Thr) rs886039434
NM_139276.2(STAT3):c.1988C>T (p.Thr663Ile) rs869312889
NM_139276.2(STAT3):c.2117T>C (p.Leu706Pro) rs1131691476
NM_139276.2(STAT3):c.2144C>T (p.Pro715Leu) rs1064794957
NM_139276.2(STAT3):c.2228G>T (p.Gly743Val) rs151033214

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