Variants in gene TP53 with conflicting interpretations "likely pathogenic" and "uncertain significance"

Submission 1 (likely pathogenic) minimum review status:		Submission 1 (likely pathogenic) method:
Submission 2 (uncertain significance) minimum review status:		Submission 2 (uncertain significance) method:
Gene type: Distinguish antisense genes from sense genes
Show significances as they were submitted (without aggregation into standard terms)
		ClinVar version:

Total variants with conflicting interpretations: 119

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HGVS	dbSNP	gnomAD frequency
NM_000546.6(TP53):c.91G>A (p.Val31Ile)	rs201753350	0.00004
NM_000546.6(TP53):c.467G>A (p.Arg156His)	rs371524413	0.00003
NM_000546.6(TP53):c.1000G>C (p.Gly334Arg)	rs730882028	0.00001
NM_000546.6(TP53):c.328C>T (p.Arg110Cys)	rs587781371	0.00001
NM_000546.6(TP53):c.374C>T (p.Thr125Met)	rs786201057	0.00001
NM_000546.6(TP53):c.472C>T (p.Arg158Cys)	rs587780068	0.00001
NM_000546.6(TP53):c.523C>T (p.Arg175Cys)	rs138729528	0.00001
NM_000546.6(TP53):c.530C>T (p.Pro177Leu)	rs751477326	0.00001
NM_000546.6(TP53):c.536A>G (p.His179Arg)	rs1057519991	0.00001
NM_000546.6(TP53):c.542G>A (p.Arg181His)	rs397514495	0.00001
NM_000546.6(TP53):c.711G>A (p.Met237Ile)	rs587782664	0.00001
NM_000546.6(TP53):c.840A>T (p.Arg280Ser)	rs1567547687	0.00001
NM_000546.6(TP53):c.1040C>A (p.Ala347Asp)	rs397516434
NM_000546.6(TP53):c.319T>G (p.Tyr107Asp)	rs368771578
NM_000546.6(TP53):c.332T>A (p.Leu111Gln)	rs1057519997
NM_000546.6(TP53):c.332T>C (p.Leu111Pro)	rs1057519997
NM_000546.6(TP53):c.337T>G (p.Phe113Val)	rs587781642
NM_000546.6(TP53):c.358A>G (p.Lys120Glu)	rs121912658
NM_000546.6(TP53):c.373A>C (p.Thr125Pro)	rs1057520003
NM_000546.6(TP53):c.377A>G (p.Tyr126Cys)	rs1555526335
NM_000546.6(TP53):c.379T>A (p.Ser127Thr)	rs1597371694
NM_000546.6(TP53):c.380C>T (p.Ser127Phe)	rs730881999
NM_000546.6(TP53):c.388C>T (p.Leu130Phe)	rs863224683
NM_000546.6(TP53):c.390CAA[1] (p.Asn131del)	rs879254214
NM_000546.6(TP53):c.394A>C (p.Lys132Gln)	rs747342068
NM_000546.6(TP53):c.400T>G (p.Phe134Val)	rs267605077
NM_000546.6(TP53):c.402T>A (p.Phe134Leu)	rs1555526278
NM_000546.6(TP53):c.404G>A (p.Cys135Tyr)	rs587781991
NM_000546.6(TP53):c.405C>G (p.Cys135Trp)	rs1057519976
NM_000546.6(TP53):c.427G>A (p.Val143Met)	rs587782620
NM_000546.6(TP53):c.434T>A (p.Leu145Gln)	rs587782197
NM_000546.6(TP53):c.434T>C (p.Leu145Pro)	rs587782197
NM_000546.6(TP53):c.440T>A (p.Val147Asp)	rs1453167097
NM_000546.6(TP53):c.464C>A (p.Thr155Asn)	rs786202752
NM_000546.6(TP53):c.469G>T (p.Val157Phe)	rs121912654
NM_000546.6(TP53):c.470T>A (p.Val157Asp)	rs1131691023
NM_000546.6(TP53):c.470T>C (p.Val157Ala)	rs1131691023
NM_000546.6(TP53):c.482C>A (p.Ala161Asp)	rs1064795691
NM_000546.6(TP53):c.482_487del (p.Ala161_Tyr163delinsAsp)	rs2073376974
NM_000546.6(TP53):c.487T>A (p.Tyr163Asn)	rs786203436
NM_000546.6(TP53):c.503A>G (p.His168Arg)	rs867114783
NM_000546.6(TP53):c.514G>T (p.Val172Phe)	rs1131691043
NM_000546.6(TP53):c.515T>A (p.Val172Asp)	rs1131691021
NM_000546.6(TP53):c.518T>A (p.Val173Glu)	rs1057519747
NM_000546.6(TP53):c.526T>A (p.Cys176Ser)	rs967461896
NM_000546.6(TP53):c.526T>C (p.Cys176Arg)	rs967461896
NM_000546.6(TP53):c.526T>G (p.Cys176Gly)	rs967461896
NM_000546.6(TP53):c.528C>G (p.Cys176Trp)	rs1057519980
NM_000546.6(TP53):c.535C>A (p.His179Asn)	rs587780070
NM_000546.6(TP53):c.536A>T (p.His179Leu)	rs1057519991
NM_000546.6(TP53):c.560-9T>A	rs794727781
NM_000546.6(TP53):c.569C>G (p.Pro190Arg)	rs876660825
NM_000546.6(TP53):c.577C>G (p.His193Asp)	rs876658468
NM_000546.6(TP53):c.578A>T (p.His193Leu)	rs786201838
NM_000546.6(TP53):c.581T>G (p.Leu194Arg)	rs1057519998
NM_000546.6(TP53):c.584T>C (p.Ile195Thr)	rs760043106
NM_000546.6(TP53):c.587G>T (p.Arg196Leu)	rs483352697
NM_000546.6(TP53):c.589G>A (p.Val197Met)	rs786204041
NM_000546.6(TP53):c.613T>A (p.Tyr205Asn)	rs1057520008
NM_000546.6(TP53):c.613T>G (p.Tyr205Asp)	rs1057520008
NM_000546.6(TP53):c.632C>T (p.Thr211Ile)	rs2073331490
NM_000546.6(TP53):c.637C>G (p.Arg213Gly)	rs397516436
NM_000546.6(TP53):c.638G>T (p.Arg213Leu)	rs587778720
NM_000546.6(TP53):c.643A>G (p.Ser215Gly)	rs886039484
NM_000546.6(TP53):c.644G>A (p.Ser215Asn)	rs587782177
NM_000546.6(TP53):c.645T>G (p.Ser215Arg)	rs1057520001
NM_000546.6(TP53):c.646G>A (p.Val216Met)	rs730882025
NM_000546.6(TP53):c.646G>T (p.Val216Leu)	rs730882025
NM_000546.6(TP53):c.653T>G (p.Val218Gly)	rs1555525743
NM_000546.6(TP53):c.655C>T (p.Pro219Ser)	rs879253894
NM_000546.6(TP53):c.658T>A (p.Tyr220Asn)	rs530941076
NM_000546.6(TP53):c.658T>G (p.Tyr220Asp)	rs530941076
NM_000546.6(TP53):c.698ACTACA[1] (p.Asn235_Tyr236del)	rs794727846
NM_000546.6(TP53):c.703A>G (p.Asn235Asp)	rs786204145
NM_000546.6(TP53):c.706T>A (p.Tyr236Asn)	rs587782289
NM_000546.6(TP53):c.706T>G (p.Tyr236Asp)	rs587782289
NM_000546.6(TP53):c.707A>G (p.Tyr236Cys)	rs730882026
NM_000546.6(TP53):c.709A>G (p.Met237Val)	rs730882004
NM_000546.6(TP53):c.715A>G (p.Asn239Asp)	rs876660807
NM_000546.6(TP53):c.717C>G (p.Asn239Lys)	rs1057522275
NM_000546.6(TP53):c.721T>G (p.Ser241Ala)	rs1057520002
NM_000546.6(TP53):c.724T>A (p.Cys242Ser)	rs1057519982
NM_000546.6(TP53):c.724T>C (p.Cys242Arg)	rs1057519982
NM_000546.6(TP53):c.725G>C (p.Cys242Ser)	rs121912655
NM_000546.6(TP53):c.733G>C (p.Gly245Arg)	rs28934575
NM_000546.6(TP53):c.745A>G (p.Arg249Gly)	rs587782082
NM_000546.6(TP53):c.745A>T (p.Arg249Trp)	rs587782082
NM_000546.6(TP53):c.746G>T (p.Arg249Met)	rs587782329
NM_000546.6(TP53):c.747G>C (p.Arg249Ser)	rs28934571
NM_000546.6(TP53):c.752T>A (p.Ile251Asn)	rs730882027
NM_000546.6(TP53):c.752T>G (p.Ile251Ser)	rs730882027
NM_000546.6(TP53):c.758C>T (p.Thr253Ile)	rs1555525465
NM_000546.6(TP53):c.763A>T (p.Ile255Phe)	rs1057519995
NM_000546.6(TP53):c.764T>A (p.Ile255Asn)	rs876659675
NM_000546.6(TP53):c.766A>C (p.Thr256Pro)	rs587781433
NM_000546.6(TP53):c.770T>C (p.Leu257Pro)	rs28934577
NM_000546.6(TP53):c.773A>G (p.Glu258Gly)	rs1060501201
NM_000546.6(TP53):c.808T>C (p.Phe270Leu)	rs1057519988
NM_000546.6(TP53):c.809T>G (p.Phe270Cys)	rs1057519986
NM_000546.6(TP53):c.815T>A (p.Val272Glu)	rs876660333
NM_000546.6(TP53):c.815T>G (p.Val272Gly)	rs876660333
NM_000546.6(TP53):c.820G>T (p.Val274Phe)	rs1057520005
NM_000546.6(TP53):c.821T>G (p.Val274Gly)	rs1057520006
NM_000546.6(TP53):c.823T>C (p.Cys275Arg)	rs1057519983
NM_000546.6(TP53):c.823T>G (p.Cys275Gly)	rs1057519983
NM_000546.6(TP53):c.824G>C (p.Cys275Ser)	rs863224451
NM_000546.6(TP53):c.827C>A (p.Ala276Asp)	rs786202082
NM_000546.6(TP53):c.830G>A (p.Cys277Tyr)	rs763098116
NM_000546.6(TP53):c.830G>T (p.Cys277Phe)	rs763098116
NM_000546.6(TP53):c.832C>G (p.Pro278Ala)	rs17849781
NM_000546.6(TP53):c.833C>A (p.Pro278His)	rs876659802
NM_000546.6(TP53):c.833C>G (p.Pro278Arg)	rs876659802
NM_000546.6(TP53):c.835G>A (p.Gly279Arg)	rs1555525248
NM_000546.6(TP53):c.836G>A (p.Gly279Glu)	rs1064793881
NM_000546.6(TP53):c.838A>G (p.Arg280Gly)	rs753660142
NM_000546.6(TP53):c.839G>T (p.Arg280Ile)	rs121912660
NM_000546.6(TP53):c.845G>A (p.Arg282Gln)	rs730882008
NM_000546.6(TP53):c.848G>C (p.Arg283Pro)	rs371409680
NM_000546.6(TP53):c.856G>C (p.Glu286Gln)	rs786201059

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