ClinVar Miner

Variants in gene TPM1 with conflicting interpretations

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Y axis minimum submission review status: Y axis collection method:
X axis minimum submission review status: X axis collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than two submissions, it may have multiple conflicts and therefore be counted in more than one conflict column. If this is the case, the "Variants with any kind of conflict" cell will be less than the sum of the conflicted variants cells to its left.

Variants with only 1 submission Variants with at least 2 submissions and no conflicts Variants with a synonymous conflict
(e.g. benign vs non-pathogenic)
Variants with a confidence conflict
(e.g. benign vs likely benign)
Variants with a benign or likely benign vs uncertain conflict Variants with a category conflict
(e.g. benign vs affects)
Variants with a clinically significant conflict
(e.g. benign vs pathogenic)
Variants with any kind of conflict
192 54 1 16 10 0 13 33

Significance breakdown #

In the table below, cells that correspond to a term paired with itself represent synonymous conflicts, i.e. variants that have been annotated with different terms that map to the same standard term. To compare the terms that were actually submitted, check the box in the filters section at the top of this page.

pathogenic likely pathogenic uncertain significance likely benign benign
pathogenic 0 8 4 0 0
likely pathogenic 8 1 12 0 0
uncertain significance 4 12 0 10 3
likely benign 0 0 10 0 8
benign 0 0 3 8 0

All variants with conflicting interpretations #

Total variants: 33
Download table as spreadsheet
HGVS dbSNP
NM_000366.5(TPM1):c.375-3C>T rs202228866
NM_000366.5(TPM1):c.845C>G (p.Thr282Ser) rs397516395
NM_001018004.1(TPM1):c.775A>G (p.Lys259Glu) rs144045691
NM_001018005.1(TPM1):c.*4001G>A rs730881128
NM_001018005.1(TPM1):c.114+14C>T rs576659891
NM_001018005.1(TPM1):c.160G>A (p.Glu54Lys) rs104894505
NM_001018005.1(TPM1):c.180C>T (p.Tyr60=) rs17850194
NM_001018005.1(TPM1):c.188C>T (p.Ala63Val) rs199476306
NM_001018005.1(TPM1):c.240+1G>A rs730881146
NM_001018005.1(TPM1):c.27G>A (p.Gln9=) rs397516365
NM_001018005.1(TPM1):c.284T>C (p.Val95Ala) rs104894504
NM_001018005.1(TPM1):c.337C>G (p.Leu113Val) rs397516369
NM_001018005.1(TPM1):c.453C>A (p.Ala151=) rs1071646
NM_001018005.1(TPM1):c.457C>G (p.His153Asp) rs397516372
NM_001018005.1(TPM1):c.460A>G (p.Ile154Val) rs1555408679
NM_001018005.1(TPM1):c.475G>A (p.Asp159Asn) rs397516373
NM_001018005.1(TPM1):c.479G>A (p.Arg160His) rs199476311
NM_001018005.1(TPM1):c.486T>C (p.Tyr162=) rs11558747
NM_001018005.1(TPM1):c.515T>C (p.Ile172Thr) rs199476312
NM_001018005.1(TPM1):c.522C>T (p.Ser174=) rs200173919
NM_001018005.1(TPM1):c.564-11G>A rs532254032
NM_001018005.1(TPM1):c.574G>A (p.Glu192Lys) rs199476315
NM_001018005.1(TPM1):c.62G>T (p.Arg21Leu) rs730881151
NM_001018005.1(TPM1):c.639+13delG rs397516488
NM_001018005.1(TPM1):c.644C>T (p.Ser215Leu) rs199476316
NM_001018005.1(TPM1):c.64G>A (p.Ala22Thr) rs397516382
NM_001018005.1(TPM1):c.712C>T (p.Arg238Trp) rs397516386
NM_001018005.1(TPM1):c.82G>C (p.Asp28His) rs397516391
NM_001018005.1(TPM1):c.842T>C (p.Met281Thr) rs199476321
NM_001018005.1(TPM1):c.851+6C>A rs375043184
NM_001018005.1(TPM1):c.851+6C>T rs375043184
NM_001018005.1(TPM1):c.98A>C (p.Glu33Ala) rs886039444
NM_001018020.1(TPM1):c.198G>C (p.Lys66Asn) rs730881126

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