ClinVar Miner

Variants in gene TPM1 with conflicting interpretations "benign" and "likely benign"

Submission 1 (benign) minimum review status: Submission 1 (benign) method:
Submission 2 (likely benign) minimum review status: Submission 2 (likely benign) method:
Gene type:
ClinVar version:
Total variants with conflicting interpretations: 30
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HGVS dbSNP gnomAD frequency
NM_001018005.2(TPM1):c.453C>A (p.Ala151=) rs1071646 0.64628
NM_001018005.2(TPM1):c.486T>C (p.Tyr162=) rs11558747 0.05001
NM_001018005.2(TPM1):c.851+99dup rs201411148 0.00955
NM_001018005.2(TPM1):c.639+22G>C rs28730802 0.00782
NM_001018020.2(TPM1):c.*31G>A rs11558748 0.00598
NM_001018005.2(TPM1):c.*76A>G rs140658011 0.00339
NM_001018005.2(TPM1):c.180C>T (p.Tyr60=) rs17850194 0.00273
NM_001018005.1(TPM1):c.-206G>A rs17525848 0.00111
NM_001018005.2(TPM1):c.115-262C>T rs74573041 0.00079
NM_001018005.2(TPM1):c.*68A>G rs374459540 0.00054
NM_001018004.2(TPM1):c.775A>G (p.Lys259Glu) rs144045691 0.00052
NM_001018005.2(TPM1):c.639+21G>C rs199989220 0.00041
NM_001018005.2(TPM1):c.177A>G (p.Lys59=) rs149346709 0.00031
NM_001018005.2(TPM1):c.375-5T>C rs377061868 0.00029
NM_001018005.2(TPM1):c.563+313A>G rs144700226 0.00029
NM_001018005.2(TPM1):c.115-214C>G rs947201175 0.00021
NM_001018005.2(TPM1):c.115-316G>A rs397516491 0.00015
NM_001018005.2(TPM1):c.114+14C>T rs576659891 0.00014
NM_001018005.2(TPM1):c.726G>A (p.Ala242=) rs200484871 0.00011
NM_001018005.2(TPM1):c.522C>T (p.Ser174=) rs200173919 0.00010
NM_001018005.2(TPM1):c.27G>A (p.Gln9=) rs397516365 0.00006
NM_001018005.2(TPM1):c.493-18T>G rs377726678 0.00006
NM_001018005.2(TPM1):c.241-8C>T rs765893032 0.00003
NM_001018005.2(TPM1):c.375-3C>T rs202228866 0.00003
NM_001018005.2(TPM1):c.663T>C (p.Tyr221=) rs774859181 0.00002
NM_001018005.1(TPM1):c.-186G>A rs541046450
NM_001018005.2(TPM1):c.115-277G>A rs1312883932
NM_001018005.2(TPM1):c.45G>A (p.Lys15=) rs199476301
NM_001018005.2(TPM1):c.639+13del rs397516488
NM_001018005.2(TPM1):c.87G>A (p.Lys29=) rs530234301

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