Variants in gene TSC2 with conflicting interpretations "likely pathogenic" and "uncertain significance"

Submission 1 (likely pathogenic) minimum review status:		Submission 1 (likely pathogenic) method:
Submission 2 (uncertain significance) minimum review status:		Submission 2 (uncertain significance) method:
Gene type: Distinguish antisense genes from sense genes
Show significances as they were submitted (without aggregation into standard terms)
		ClinVar version:

Total variants with conflicting interpretations: 23

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HGVS	dbSNP	gnomAD frequency
NM_000548.5(TSC2):c.5260-1G>C	rs1057518103	0.00003
NM_000548.5(TSC2):c.886G>A (p.Val296Met)	rs747237113	0.00001
NM_000548.5(TSC2):c.1001T>C (p.Val334Ala)	rs45484892
NM_000548.5(TSC2):c.1229T>G (p.Leu410Arg)	rs137854298
NM_000548.5(TSC2):c.1257+5G>A	rs2151157428
NM_000548.5(TSC2):c.1343T>C (p.Leu448Pro)	rs397515206
NM_000548.5(TSC2):c.1778A>G (p.His593Arg)	rs45517198
NM_000548.5(TSC2):c.1835T>C (p.Leu612Pro)	rs1567458244
NM_000548.5(TSC2):c.1865G>C (p.Arg622Pro)	rs45517206
NM_000548.5(TSC2):c.2113G>A (p.Val705Met)	rs397515241
NM_000548.5(TSC2):c.225+2T>C	rs397515105
NM_000548.5(TSC2):c.2339T>C (p.Leu780Pro)	rs2151328709
NM_000548.5(TSC2):c.2355G>A (p.Gln785=)	rs2088708544
NM_000548.5(TSC2):c.2356-4_2356-3delinsAG
NM_000548.5(TSC2):c.2447C>T (p.Pro816Leu)	rs45517236
NM_000548.5(TSC2):c.2774A>G (p.Asp925Gly)	rs1555508942
NM_000548.5(TSC2):c.2859dup (p.Lys954fs)	rs796053504
NM_000548.5(TSC2):c.4628A>G (p.His1543Arg)	rs2090628516
NM_000548.5(TSC2):c.5068G>A (p.Asp1690Asn)	rs137854882
NM_000548.5(TSC2):c.5254C>T (p.Gln1752Ter)	rs45517414
NM_000548.5(TSC2):c.884C>A (p.Ala295Asp)	rs1596288578
NM_000548.5(TSC2):c.910T>C (p.Trp304Arg)	rs397515108
Single allele

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