ClinVar Miner

Variants in gene TUBB3 with conflicting interpretations

Y axis minimum submission review status: Y axis collection method:
X axis minimum submission review status: X axis collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than two submissions, it may have multiple conflicts and therefore be counted in more than one conflict column. If this is the case, the "Variants with any kind of conflict" cell will be less than the sum of the conflicted variants cells to its left.

Variants with only 1 submission per condition Variants with at least 2 submissions on the same condition and no conflicts Variants with a synonymous conflict
(e.g. benign vs non-pathogenic)
Variants with a confidence conflict
(e.g. benign vs likely benign)
Variants with a benign or likely benign vs uncertain conflict Variants with a category conflict
(e.g. benign vs affects)
Variants with a clinically significant conflict
(e.g. benign vs pathogenic)
Variants with any conflict
80 12 0 9 5 0 3 15

Significance breakdown #

In the table below, cells that correspond to a term paired with itself represent synonymous conflicts, i.e. variants that have been annotated with different terms that map to the same standard term. To compare the terms that were actually submitted, check the box in the filters section at the top of this page.

pathogenic likely pathogenic uncertain significance likely benign benign
pathogenic 0 2 1 0 0
likely pathogenic 2 0 2 0 0
uncertain significance 1 2 0 5 2
likely benign 0 0 5 0 7
benign 0 0 2 7 0

All variants with conflicting interpretations #

Total variants: 15
Download table as spreadsheet
HGVS dbSNP
NM_006086.4(TUBB3):c.1215G>A (p.Glu405=) rs141064323
NM_006086.4(TUBB3):c.1287G>A (p.Thr429=) rs142238093
NM_006086.4(TUBB3):c.167-5C>G rs147928399
NM_006086.4(TUBB3):c.210C>T (p.Pro70=) rs754683361
NM_006086.4(TUBB3):c.292G>A (p.Gly98Ser) rs587784505
NM_006086.4(TUBB3):c.357G>A (p.Val119=) rs34174718
NM_006086.4(TUBB3):c.447G>A (p.Thr149=) rs371662941
NM_006086.4(TUBB3):c.533C>T (p.Thr178Met) rs747480526
NM_006086.4(TUBB3):c.606C>T (p.Ile202=) rs576180572
NM_006086.4(TUBB3):c.666C>T (p.Tyr222=) rs61743676
NM_006086.4(TUBB3):c.689C>T (p.Ser230Leu) rs886041459
NM_006086.4(TUBB3):c.702C>T (p.Ser234=) rs147245174
NM_006086.4(TUBB3):c.728C>T (p.Pro243Leu) rs587784506
NM_006086.4(TUBB3):c.785G>A (p.Arg262His) rs864321716
NM_006086.4(TUBB3):c.921C>T (p.His307=) rs147283850

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