ClinVar Miner

Variants in gene WRN with conflicting interpretations "benign" and "likely benign"

Submission 1 (benign) minimum review status: Submission 1 (benign) method:
Submission 2 (likely benign) minimum review status: Submission 2 (likely benign) method:
Gene type:
ClinVar version:
Total variants with conflicting interpretations: 31
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HGVS dbSNP gnomAD frequency
NM_000553.6(WRN):c.3222G>T (p.Leu1074Phe) rs1801195 0.46398
NM_000553.6(WRN):c.3138+7G>A rs2737335 0.46167
NM_000553.6(WRN):c.2361G>T (p.Leu787=) rs1800392 0.44644
NM_000553.6(WRN):c.3138+6C>T rs3024239 0.40457
NM_000553.6(WRN):c.4083C>T (p.Ser1361=) rs1801196 0.28751
NM_000553.6(WRN):c.4099T>C (p.Cys1367Arg) rs1346044 0.22580
NM_000553.6(WRN):c.340G>A (p.Val114Ile) rs2230009 0.07797
NM_000553.6(WRN):c.1577-3C>A rs3087409 0.07689
NM_000553.6(WRN):c.1161G>A (p.Met387Ile) rs1800391 0.06125
NM_000553.6(WRN):c.3236C>T (p.Ser1079Leu) rs3087414 0.01577
NM_000553.6(WRN):c.2241T>G (p.Leu747=) rs2230011 0.00921
NM_000553.6(WRN):c.1953C>T (p.Gly651=) rs11574263 0.00627
NM_000553.6(WRN):c.1725T>C (p.Tyr575=) rs13438802 0.00516
NM_000553.6(WRN):c.1788T>C (p.Ser596=) rs13438803 0.00477
NM_000553.6(WRN):c.4015G>A (p.Val1339Ile) rs11574395 0.00418
NM_000553.6(WRN):c.1577-17T>G rs145080962 0.00343
NM_000553.6(WRN):c.95A>G (p.Lys32Arg) rs34477820 0.00303
NM_000553.6(WRN):c.3785C>G (p.Thr1262Arg) rs78488552 0.00275
NM_000553.6(WRN):c.970A>G (p.Thr324Ala) rs1800390 0.00245
NM_000553.6(WRN):c.2983G>A (p.Ala995Thr) rs140768346 0.00194
NM_000553.6(WRN):c.1149G>T (p.Leu383Phe) rs4987238 0.00148
NM_000553.6(WRN):c.2500C>T (p.Arg834Cys) rs3087425 0.00097
NM_000553.6(WRN):c.3237G>A (p.Ser1079=) rs11574345 0.00069
NM_000553.6(WRN):c.3422C>T (p.Ser1141Leu) rs139323683 0.00052
NM_000553.6(WRN):c.1882C>G (p.Leu628Val) rs77969734 0.00050
NM_000553.6(WRN):c.3738G>A (p.Leu1246=) rs147117969 0.00045
NM_000553.6(WRN):c.1989G>A (p.Thr663=) rs201982706 0.00038
NM_000553.6(WRN):c.3101A>T (p.Tyr1034Phe) rs200370409 0.00026
NM_000553.6(WRN):c.725-9T>C rs1060503821 0.00001
NM_000553.6(WRN):c.1899-10G>T rs748285435
NM_000553.6(WRN):c.1982-5del rs397723919

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