Variants in gene WRN with conflicting interpretations "benign" and "uncertain significance"

Submission 1 (benign) minimum review status:		Submission 1 (benign) method:
Submission 2 (uncertain significance) minimum review status:		Submission 2 (uncertain significance) method:
Gene type: Distinguish antisense genes from sense genes
Show significances as they were submitted (without aggregation into standard terms)
		ClinVar version:

Total variants with conflicting interpretations: 20

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HGVS	dbSNP	gnomAD frequency
NM_000553.6(WRN):c.95A>G (p.Lys32Arg)	rs34477820	0.00310
NM_000553.6(WRN):c.3785C>G (p.Thr1262Arg)	rs78488552	0.00276
NM_000553.6(WRN):c.1981+11A>G	rs189999761	0.00240
NM_000553.6(WRN):c.2983G>A (p.Ala995Thr)	rs140768346	0.00193
NM_000553.6(WRN):c.1717A>G (p.Thr573Ala)	rs150148567	0.00169
NM_000553.6(WRN):c.355+4G>C	rs145764920	0.00156
NM_000553.6(WRN):c.1149G>T (p.Leu383Phe)	rs4987238	0.00148
NM_000553.6(WRN):c.3875C>A (p.Ser1292Tyr)	rs142614369	0.00132
NM_000553.6(WRN):c.2937T>G (p.Ile979Met)	rs147802438	0.00131
NM_000553.6(WRN):c.3900C>A (p.Pro1300=)	rs138886038	0.00089
NM_000553.6(WRN):c.720T>G (p.Asn240Lys)	rs148229804	0.00085
NM_000553.6(WRN):c.3453G>A (p.Glu1151=)	rs144116311	0.00054
NM_000553.6(WRN):c.3422C>T (p.Ser1141Leu)	rs139323683	0.00052
NM_000553.6(WRN):c.1909C>T (p.Arg637Trp)	rs148286708	0.00028
NM_000553.6(WRN):c.1530A>T (p.Glu510Asp)	rs149565907	0.00026
NM_000553.6(WRN):c.3820-12A>G	rs374684032	0.00021
NM_000553.6(WRN):c.2342C>T (p.Thr781Ile)	rs17847568	0.00003
NM_000553.6(WRN):c.1378G>A (p.Asp460Asn)	rs556958354	0.00002
NM_000553.6(WRN):c.16T>C (p.Leu6=)	rs202148988
NM_000553.6(WRN):c.4180A>G (p.Ile1394Val)	rs545431480

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