ClinVar Miner

Variants with conflicting interpretations "likely benign" from GeneDx and "drug response" from any submitter

Minimum review status of the submission from GeneDx: Collection method of the submission from GeneDx:
Minimum review status of the other submission: Collection method of the other submission:
ClinVar version:
Total variants with conflicting interpretations: 27
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HGVS dbSNP gnomAD frequency
NM_000106.6(CYP2D6):c.1457= (p.Ser486=) rs1135840 0.42305
NM_024006.4(VKORC1):c.-1639G>A rs9923231 0.31157
NM_024006.6(VKORC1):c.174-136C>T rs9934438 0.31147
CYP2D6*10 rs1065852 0.18675
NM_000769.4(CYP2C19):c.681G>A (p.Pro227=) rs4244285 0.16148
CYP2D6*4 rs3892097 0.14340
CYP2C9*2 rs1799853 0.08975
CYP2D6*41 rs28371725 0.06736
NM_000106.6(CYP2D6):c.31G>A (p.Val11Met) rs769258 0.03995
NM_000110.4(DPYD):c.1601G>A (p.Ser534Asn) rs1801158 0.01380
NM_000106.6(CYP2D6):c.775del (p.Arg259fs) rs35742686 0.01277
NM_001025195.2(CES1):c.431G>A (p.Gly144Glu) rs71647871 0.00998
CYP2D6*6 rs5030655 0.00883
NM_000106.6(CYP2D6):c.709G>T (p.Ala237Ser) rs28371717 0.00827
CYP2C9*11 rs28371685 0.00738
NM_000769.1(CYP2C19):c.431G>A (p.Arg144His) rs17884712 0.00391
CYP2C9*5 rs28371686 0.00342
NM_000769.1(CYP2C19):c.1A>G (p.Met1Val) rs28399504 0.00156
NM_000169.3(GLA):c.865A>G (p.Ile289Val) rs140329381 0.00009
CYP2C9*6 rs9332131
CYP2C9*8 rs7900194
CYP2D6*17 rs28371706
NM_000106.5(CYP2D6):c.505G>T (p.Gly169Ter) rs5030865
NM_000106.6(CYP2D6):c.841_843del (p.Lys281del) rs5030656
NM_000106.6(CYP2D6):c.886= (p.Arg296=) rs16947
NM_000169.3(GLA):c.937G>A (p.Asp313Asn) rs28935490
NM_024006.6(VKORC1):c.283+124G>C rs8050894

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