ClinVar Miner

Variants from Section on Medical Neuroendocrinolgy,National Institutes of Health with conflicting interpretations

Location: United States — Primary collection method: research
Minimum review status of the submission from Section on Medical Neuroendocrinolgy,National Institutes of Health: Collection method of the submission from Section on Medical Neuroendocrinolgy,National Institutes of Health:
Minimum review status of the other submission: Collection method of the other submission:
Minimum conflict level:
ClinVar version:

If a variant has more than two submissions, it may have multiple conflicts and therefore be counted in more than one conflict column. If this is the case, the "Variants with any kind of conflict" cell will be less than the sum of the conflicted variants cells to its left.

Variants with only 1 submission per condition Variants with at least 2 submissions on the same condition and no conflicts Variants with a synonymous conflict
(e.g. benign vs non-pathogenic)
Variants with a confidence conflict
(e.g. benign vs likely benign)
Variants with a benign or likely benign vs uncertain conflict Variants with a category conflict
(e.g. benign vs affects)
Variants with a clinically significant conflict
(e.g. benign vs pathogenic)
Variants with any conflict
69 7 2 2 0 0 0 4

Significance breakdown #

In the table below, cells that correspond to a term paired with itself represent synonymous conflicts, i.e. variants that have been annotated with different terms that map to the same standard term. To compare the terms that were actually submitted, check the box in the filters section at the top of this page.

All submitters
Section on Medical Neuroendocrinolgy,National Institutes of Health pathogenic likely pathogenic
pathogenic 2 2

Submitter to submitter summary #

Total submitters: 2
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Submitter Variants with only 1 submission per condition Variants with at least 2 submissions on the same condition and no conflicts Variants with a synonymous conflict
(e.g. benign vs non-pathogenic)
Variants with a confidence conflict
(e.g. benign vs likely benign)
Variants with a benign or likely benign vs uncertain conflict Variants with a category conflict
(e.g. benign vs affects)
Variants with a clinically significant conflict
(e.g. benign vs pathogenic)
Variants with any conflict
Laboratory for Molecular Medicine, Partners HealthCare Personalized Medicine 0 7 0 2 0 0 0 2
GeneReviews 0 0 2 0 0 0 0 2

All variants with conflicting interpretations #

Total variants: 4
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HGVS dbSNP
NM_003000.3(SDHB):c.137G>A (p.Arg46Gln) rs772551056
NM_003000.3(SDHB):c.287-1G>C rs397516833
NM_003002.4(SDHD):c.112C>T (p.Arg38Ter) rs80338843
NM_003002.4(SDHD):c.242C>T (p.Pro81Leu) rs80338844

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