Variants from Central Laboratory, The First Hospital of Lanzhou University with conflicting interpretations

Minimum review status of the submission from Central Laboratory, The First Hospital of Lanzhou University:	★☆☆☆ criteria provided ★★★☆ reviewed by expert panel ★★★★ practice guideline	Collection method of the submission from Central Laboratory, The First Hospital of Lanzhou University:	clinical testing curation literature only research other
Minimum review status of the other submission:	★☆☆☆ criteria provided ★★★☆ reviewed by expert panel ★★★★ practice guideline	Collection method of the other submission:	clinical testing curation literature only research other
Minimum conflict level: confidence conflict (e.g. benign vs likely benign) benign or likely benign vs uncertain conflict category conflict (e.g. benign vs affects) clinically significant conflict (e.g. benign vs pathogenic) Report conflict between different conditions
Show significances as they were submitted (without aggregation into standard terms)
		ClinVar version: 2024-03-31

If a variant has more than two submissions, it may have multiple conflicts and therefore be counted in more than one conflict column. If this is the case, the "Variants with any kind of conflict" cell will be less than the sum of the conflicted variants cells to its left.

Variants with only 1 submission per condition	Variants with at least 2 submissions on the same condition and no conflicts	Variants with a synonymous conflict (e.g. benign vs non-pathogenic)	Variants with a confidence conflict (e.g. benign vs likely benign)	Variants with a benign or likely benign vs uncertain conflict	Variants with a category conflict (e.g. benign vs affects)	Variants with a clinically significant conflict (e.g. benign vs pathogenic)	Variants with any conflict
0	0	0	1	0	1	1	1

Significance breakdown #

In the table below, cells that correspond to a term paired with itself represent synonymous conflicts, i.e. variants that have been annotated with different terms that map to the same standard term. To compare the terms that were actually submitted, check the box in the filters section at the top of this page.

	All submitters
Central Laboratory, The First Hospital of Lanzhou University		likely pathogenic	uncertain significance	likely benign	benign	protective	other
	pathogenic	1	1	1	1	1	1

Submitter to submitter summary #

Submitter	Variants with only 1 submission per condition	Variants with at least 2 submissions on the same condition and no conflicts	Variants with a synonymous conflict (e.g. benign vs non-pathogenic)	Variants with a confidence conflict (e.g. benign vs likely benign)	Variants with a benign or likely benign vs uncertain conflict	Variants with a category conflict (e.g. benign vs affects)	Variants with a clinically significant conflict (e.g. benign vs pathogenic)	Variants with any conflict
Athena Diagnostics Inc	0	0	0	1	0	0	1	1
Laboratory for Molecular Medicine, Mass General Brigham Personalized Medicine	0	0	0	0	0	0	1	1
GeneDx	0	0	0	1	0	0	1	1
PreventionGenetics, part of Exact Sciences	0	0	0	0	0	0	1	1
Invitae	0	0	0	0	0	0	1	1
Eurofins Ntd Llc (ga)	0	0	0	1	0	1	1	1
Mayo Clinic Laboratories, Mayo Clinic	0	0	0	1	0	0	1	1
Quest Diagnostics Nichols Institute San Juan Capistrano	0	0	0	0	0	0	1	1
Department Of Translational Genomics (developmental Genetics Section), King Faisal Specialist Hospital & Research Centre	0	0	0	1	0	0	0	1
Illumina Laboratory Services, Illumina	0	0	0	1	0	0	1	1
Vavilov Institute of General Genetics RAS, Laboratory of Evolutional Genomics	0	0	0	0	0	1	0	1
University of Washington Center for Mendelian Genomics, University of Washington	0	0	0	1	0	0	0	1
Lupski Lab, Baylor-Hopkins CMG, Baylor College of Medicine	0	0	0	1	0	0	1	1
Genome Sciences Centre, British Columbia Cancer Agency	0	0	0	1	0	0	0	1
CeGaT Center for Human Genetics Tuebingen	0	0	0	0	0	0	1	1
NIHR Bioresource Rare Diseases, University of Cambridge	0	0	0	1	0	0	0	1
Undiagnosed Diseases Network, NIH	0	0	0	1	0	0	1	1
Equipe Genetique des Anomalies du Developpement, Université de Bourgogne	0	0	0	1	0	0	1	1
Rady Children's Institute for Genomic Medicine, Rady Children's Hospital San Diego	0	0	0	0	0	0	1	1
Department of Pathology and Laboratory Medicine, Sinai Health System	0	0	0	0	0	0	1	1
Geisinger Autism and Developmental Medicine Institute, Geisinger Health System	0	0	0	1	0	0	1	1
Rare Disease Group, Clinical Genetics, Karolinska Institutet	0	0	0	1	0	0	1	1
Institute of Cellular and Molecular Medicine, Copenhagen University	0	0	0	1	0	0	0	1
Laboratory of Diagnostic Genome Analysis, Leiden University Medical Center (LUMC)	0	0	0	0	0	0	1	1
Clinical Genetics DNA and cytogenetics Diagnostics Lab, Erasmus MC, Erasmus Medical Center	0	0	0	0	0	0	1	1
Laboratoire de Genetique Moleculaire, Centre Hospitalier Universitaire de Bordeaux	0	0	0	0	0	0	1	1
Medical Genetics Lab, Policlinico S. Orsola.Malpighi	0	0	0	1	0	0	1	1
Medical Cytogenetics and Molecular Genetics Laboratory, IRCCS Istituto Auxologico Italiano	0	0	0	0	0	0	1	1
Molecular Pathology Diagnostics Labratory, University of Iowa Hospitals & Clinics	0	0	0	1	0	0	0	1
Biochemistry Laboratory of CDMU, Chengde Medical University	0	0	0	1	0	0	0	1
Rare Disease Group, University of Exeter	0	0	0	1	0	0	0	1
New York Genome Center	0	0	0	1	0	0	1	1
Genetics and Prenatal Diagnosis Center, The First Affiliated Hospital of Zhengzhou University	0	0	0	1	0	0	0	1
IU Genetic Testing Laboratories, Indiana University School of Medicine	0	0	0	1	0	0	0	1

All variants with conflicting interpretations #

HGVS	dbSNP	gnomAD frequency
Single allele