ClinVar Miner

Variants studied for Acute myeloid leukemia

Coded as:
Minimum submission review status: Collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign not provided total
68 174 301 147 11 2 697

Gene and significance breakdown #

Total genes and gene combinations: 37
Download table as spreadsheet
Gene or gene combination pathogenic likely pathogenic uncertain significance likely benign benign not provided total
CEBPA 17 5 283 147 11 1 461
TP53 0 62 0 0 0 0 62
FLT3 11 26 0 0 0 1 37
NRAS 0 15 0 0 0 0 15
HRAS, LRRC56 0 13 0 0 0 0 13
RUNX1 1 7 5 0 0 0 13
SF3B1 0 13 0 0 0 0 13
NPM1 5 4 0 0 0 0 9
IDH2 6 2 0 0 0 0 8
DNMT3A 6 1 0 0 0 0 7
IDH1 6 0 1 0 0 0 7
KRAS 2 5 0 0 0 0 6
KIT 3 2 0 0 0 0 5
DDX41 2 2 0 0 0 0 4
GATA2 0 2 2 0 0 0 4
U2AF1 0 4 0 0 0 0 4
ETV6 3 0 0 0 0 0 3
PTPN11 0 3 0 0 0 0 3
TERT 1 1 1 0 0 0 3
INSL6, JAK2 2 1 0 0 0 0 2
WT1 0 1 1 0 0 0 2
ALK 0 0 1 0 0 0 1
ATG2B, BDKRB1, BDKRB2, C14orf132, GSKIP, LOC107984703, LOC112272571, TCL1A, TUNAR 0 1 0 0 0 0 1
CBFB 0 0 1 0 0 0 1
CEBPA, GPATCH1, LRP3, RHPN2, SLC7A10, WDR88 0 0 1 0 0 0 1
CSF3R 0 1 0 0 0 0 1
JAK1 0 1 0 0 0 0 1
LOC100507346, PTCH1 0 0 1 0 0 0 1
LPP 0 0 1 0 0 0 1
MLLT10 0 0 1 0 0 0 1
NSD1 1 0 0 0 0 0 1
RTEL1, RTEL1-TNFRSF6B 1 0 0 0 0 0 1
SF3B2 0 1 0 0 0 0 1
TEK 0 1 0 0 0 0 1
TGM6 1 0 0 0 0 0 1
TMEM127 0 0 1 0 0 0 1
TSC1 0 0 1 0 0 0 1

Submitter and significance breakdown #

Total submitters: 23
Download table as spreadsheet
Submitter pathogenic likely pathogenic uncertain significance likely benign benign not provided total
Invitae 3 5 281 147 9 0 445
Database of Curated Mutations (DoCM) 30 162 0 0 0 0 192
OMIM 26 0 0 0 0 0 26
GeneReviews 7 0 0 0 3 0 10
Baylor Genetics 1 0 7 0 0 0 8
St. Jude Clinical Genomics Lab, St. Jude Children's Research Hospital 0 0 5 1 0 0 6
Fulgent Genetics,Fulgent Genetics 0 0 5 0 0 0 5
Bone Marrow Failure laboratory,Queen Mary University London 2 3 0 0 0 0 5
Genetic Services Laboratory, University of Chicago 3 1 0 0 0 0 4
Johns Hopkins Genomics, Johns Hopkins University 0 1 3 0 0 0 4
NIHR Bioresource Rare Diseases, University of Cambridge 1 1 0 0 0 0 2
Molecular Diagnostics Laboratory, M Health Fairview: University of Minnesota 1 0 1 0 0 0 2
Godley laboratory, The University of Chicago 2 0 0 0 0 0 2
Hematopathology,The University of Texas M.D. Anderson Cancer Center 2 0 0 0 0 0 2
Fujian Institute of Hematology,Fujian Medical University 1 0 0 0 0 0 1
INSERM UMR 1170,INSERM 0 1 0 0 0 0 1
Centre for Mendelian Genomics,University Medical Centre Ljubljana 0 0 1 0 0 0 1
GenomeConnect, ClinGen 0 0 0 0 0 1 1
Center for Genomics, Ann and Robert H. Lurie Children's Hospital of Chicago 0 0 1 0 0 0 1
Laboratory Oncology Unit, Dr.B.R.A. Institute Rotary Cancer Hospital,All India Institute of Medical Sciences 0 0 1 0 0 0 1
Molecular Haematology Laboratory,NSW Health Pathology 1 0 0 0 0 0 1
Malcovati Lab, University of Pavia 0 0 1 0 0 0 1
GenomeConnect - Invitae Patient Insights Network 0 0 0 0 0 1 1

The information on this website is not intended for direct diagnostic use or medical decision-making without review by a genetics professional. Individuals should not change their health behavior solely on the basis of information contained on this website. Neither the University of Utah nor the National Institutes of Health independently verfies the submitted information. If you have questions about the information contained on this website, please see a health care professional.