ClinVar Miner

Variants studied for Acute myeloid leukemia

Coded as:
Minimum submission review status: Collection method:
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Gene type:
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If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign not provided total
63 169 230 60 11 1 531

Gene and significance breakdown #

Total genes and gene combinations: 37
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Gene or gene combination pathogenic likely pathogenic uncertain significance likely benign benign not provided total
CEBPA 17 4 217 60 11 0 308
TP53 0 62 0 0 0 0 62
FLT3 11 26 0 0 0 1 37
NRAS 0 15 0 0 0 0 15
HRAS, LRRC56 0 13 0 0 0 0 13
SF3B1 0 13 0 0 0 0 13
NPM1 5 4 0 0 0 0 9
IDH2 6 2 0 0 0 0 8
DNMT3A 6 1 0 0 0 0 7
IDH1 6 0 0 0 0 0 6
KRAS 1 5 0 0 0 0 6
RUNX1 0 5 1 0 0 0 6
KIT 3 2 0 0 0 0 5
U2AF1 0 4 0 0 0 0 4
BRCA2 0 0 3 0 0 0 3
PTPN11 0 3 0 0 0 0 3
ETV6 2 0 0 0 0 0 2
GATA2 0 2 0 0 0 0 2
INSL6, JAK2 2 1 0 0 0 0 2
TERT 1 1 0 0 0 0 2
WT1 0 1 1 0 0 0 2
ALK 0 0 1 0 0 0 1
ATG2B, BDKRB1, BDKRB2, C14orf132, GSKIP, LOC107984703, LOC112272571, TCL1A, TUNAR 0 1 0 0 0 0 1
CDH1 0 0 1 0 0 0 1
CSF3R 0 1 0 0 0 0 1
DDX41 1 0 0 0 0 0 1
DICER1 0 0 1 0 0 0 1
JAK1 0 1 0 0 0 0 1
LOC100507346, PTCH1 0 0 1 0 0 0 1
MSH2 0 0 1 0 0 0 1
PAX5 0 0 1 0 0 0 1
RTEL1, RTEL1-TNFRSF6B 1 0 0 0 0 0 1
SF3B2 0 1 0 0 0 0 1
TEK 0 1 0 0 0 0 1
TGM6 1 0 0 0 0 0 1
TMEM127 0 0 1 0 0 0 1
TSC1 0 0 1 0 0 0 1

Submitter and significance breakdown #

Total submitters: 16
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Submitter pathogenic likely pathogenic uncertain significance likely benign benign not provided total
Invitae 3 4 215 60 8 0 290
Database of Curated Mutations (DoCM) 30 162 0 0 0 0 192
OMIM 26 0 0 0 0 0 26
Clinical Genomics Lab,St. Jude Children's Research Hospital 0 0 11 0 0 0 11
GeneReviews 6 0 0 0 3 0 9
Fulgent Genetics,Fulgent Genetics 0 0 5 0 0 0 5
Genetic Services Laboratory, University of Chicago 3 1 0 0 0 0 4
NIHR Bioresource Rare Diseases, University of Cambridge 1 1 0 0 0 0 2
Godley laboratory, The University of Chicago 2 0 0 0 0 0 2
Fujian Institute of Hematology,Fujian Medical University 1 0 0 0 0 0 1
INSERM UMR 1170,INSERM 0 1 0 0 0 0 1
GenomeConnect, ClinGen 0 0 0 0 0 1 1
Center for Genomics, Ann and Robert H. Lurie Children's Hospital of Chicago 0 0 1 0 0 0 1
Johns Hopkins Genomics,Johns Hopkins University 0 0 1 0 0 0 1
Laboratory Oncology Unit, Dr.B.R.A. Institute Rotary Cancer Hospital,All India Institute of Medical Sciences 0 0 1 0 0 0 1
Molecular Haematology Laboratory,NSW Health Pathology 1 0 0 0 0 0 1

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