ClinVar Miner

Variants studied for Acute myeloid leukemia

Coded as:
Minimum submission review status: Collection method:
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Gene type:
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If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign not provided total
58 165 114 32 10 1 378

Gene and significance breakdown #

Total genes and gene combinations: 36
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Gene or gene combination pathogenic likely pathogenic uncertain significance likely benign benign not provided total
CEBPA 14 1 102 32 10 0 159
TP53 0 62 0 0 0 0 62
FLT3 11 26 0 0 0 1 37
NRAS 0 15 0 0 0 0 15
HRAS, LRRC56 0 13 0 0 0 0 13
SF3B1 0 13 0 0 0 0 13
NPM1 5 4 0 0 0 0 9
IDH2 6 2 0 0 0 0 8
DNMT3A 6 0 0 0 0 0 6
IDH1 6 0 0 0 0 0 6
KRAS 1 5 0 0 0 0 6
KIT 3 2 0 0 0 0 5
RUNX1 0 5 0 0 0 0 5
U2AF1 0 4 0 0 0 0 4
BRCA2 0 0 3 0 0 0 3
PTPN11 0 3 0 0 0 0 3
ETV6 2 0 0 0 0 0 2
GATA2 0 2 0 0 0 0 2
INSL6, JAK2 2 1 0 0 0 0 2
WT1 0 1 1 0 0 0 2
ALK 0 0 1 0 0 0 1
ATG2B, BDKRB1, BDKRB2, C14orf132, GSKIP, LOC107984703, LOC112272571, TCL1A, TUNAR 0 1 0 0 0 0 1
CDH1 0 0 1 0 0 0 1
CSF3R 0 1 0 0 0 0 1
DDX41 1 0 0 0 0 0 1
DICER1 0 0 1 0 0 0 1
JAK1 0 1 0 0 0 0 1
LOC100507346, PTCH1 0 0 1 0 0 0 1
MSH2 0 0 1 0 0 0 1
PAX5 0 0 1 0 0 0 1
SF3B2 0 1 0 0 0 0 1
TEK 0 1 0 0 0 0 1
TERT 0 1 0 0 0 0 1
TGM6 1 0 0 0 0 0 1
TMEM127 0 0 1 0 0 0 1
TSC1 0 0 1 0 0 0 1

Submitter and significance breakdown #

Total submitters: 13
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Submitter pathogenic likely pathogenic uncertain significance likely benign benign not provided total
Database of Curated Mutations (DoCM) 30 162 0 0 0 0 192
Invitae 0 1 101 32 7 0 141
OMIM 26 0 0 0 0 0 26
Clinical Genomics Lab,St. Jude Children's Research Hospital 0 0 11 0 0 0 11
GeneReviews 6 0 0 0 3 0 9
Fulgent Genetics 0 0 5 0 0 0 5
Genetic Services Laboratory, University of Chicago 3 1 0 0 0 0 4
Fujian Institute of Hematology,Fujian Medical University 1 0 0 0 0 0 1
INSERM UMR 1170,INSERM 0 1 0 0 0 0 1
GenomeConnect, ClinGen 0 0 0 0 0 1 1
Center for Genomics, Ann and Robert H. Lurie Children's Hospital of Chicago 0 0 1 0 0 0 1
Laboratory Oncology Unit, Dr.B.R.A. Institute Rotary Cancer Hospital,All India Institute of Medical Sciences 0 0 1 0 0 0 1
Molecular Haematology Laboratory,NSW Health Pathology 1 0 0 0 0 0 1

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