ClinVar Miner

Variants studied for Acute myeloid leukemia

Coded as:
Minimum submission review status: Collection method:
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Gene type:
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If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign not provided total
59 167 151 13 5 1 394

Gene and significance breakdown #

Total genes and gene combinations: 36
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Gene or gene combination pathogenic likely pathogenic uncertain significance likely benign benign not provided total
CEBPA 15 2 139 13 5 0 174
TP53 0 62 0 0 0 0 62
FLT3 11 26 0 0 0 1 37
NRAS 0 15 0 0 0 0 15
HRAS, LRRC56 0 13 0 0 0 0 13
SF3B1 0 13 0 0 0 0 13
NPM1 5 4 0 0 0 0 9
IDH2 6 2 0 0 0 0 8
DNMT3A 6 1 0 0 0 0 7
IDH1 6 0 0 0 0 0 6
KRAS 1 5 0 0 0 0 6
KIT 3 2 0 0 0 0 5
RUNX1 0 5 0 0 0 0 5
U2AF1 0 4 0 0 0 0 4
BRCA2 0 0 3 0 0 0 3
PTPN11 0 3 0 0 0 0 3
ETV6 2 0 0 0 0 0 2
GATA2 0 2 0 0 0 0 2
INSL6, JAK2 2 1 0 0 0 0 2
WT1 0 1 1 0 0 0 2
ALK 0 0 1 0 0 0 1
ATG2B, BDKRB1, BDKRB2, C14orf132, GSKIP, LOC107984703, LOC112272571, TCL1A, TUNAR 0 1 0 0 0 0 1
CDH1 0 0 1 0 0 0 1
CSF3R 0 1 0 0 0 0 1
DDX41 1 0 0 0 0 0 1
DICER1 0 0 1 0 0 0 1
JAK1 0 1 0 0 0 0 1
LOC100507346, PTCH1 0 0 1 0 0 0 1
MSH2 0 0 1 0 0 0 1
PAX5 0 0 1 0 0 0 1
SF3B2 0 1 0 0 0 0 1
TEK 0 1 0 0 0 0 1
TERT 0 1 0 0 0 0 1
TGM6 1 0 0 0 0 0 1
TMEM127 0 0 1 0 0 0 1
TSC1 0 0 1 0 0 0 1

Submitter and significance breakdown #

Total submitters: 14
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Submitter pathogenic likely pathogenic uncertain significance likely benign benign not provided total
Database of Curated Mutations (DoCM) 30 162 0 0 0 0 192
Invitae 1 2 137 13 2 0 155
OMIM 26 0 0 0 0 0 26
Clinical Genomics Lab,St. Jude Children's Research Hospital 0 0 11 0 0 0 11
GeneReviews 6 0 0 0 3 0 9
Fulgent Genetics,Fulgent Genetics 0 0 5 0 0 0 5
Genetic Services Laboratory, University of Chicago 3 1 0 0 0 0 4
NIHR Bioresource Rare Diseases, University of Cambridge 1 1 0 0 0 0 2
Fujian Institute of Hematology,Fujian Medical University 1 0 0 0 0 0 1
INSERM UMR 1170,INSERM 0 1 0 0 0 0 1
GenomeConnect, ClinGen 0 0 0 0 0 1 1
Center for Genomics, Ann and Robert H. Lurie Children's Hospital of Chicago 0 0 1 0 0 0 1
Laboratory Oncology Unit, Dr.B.R.A. Institute Rotary Cancer Hospital,All India Institute of Medical Sciences 0 0 1 0 0 0 1
Molecular Haematology Laboratory,NSW Health Pathology 1 0 0 0 0 0 1

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