Variants studied for Lung adenocarcinoma

Minimum submission review status:		Collection method:
Minimum conflict level: Report conflict between different conditions
Gene type: Distinguish antisense genes from sense genes
Show significances as they were submitted (without aggregation into standard terms)
		ClinVar version:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic	likely pathogenic	uncertain significance	likely benign	benign	not provided	total
21	414	84	4	4	1	519

Gene and significance breakdown #

Total genes and gene combinations: 75

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Gene or gene combination	pathogenic	likely pathogenic	uncertain significance	likely benign	benign	not provided	total
TP53	5	194	3	0	0	0	200
EGFR	4	28	3	0	0	0	33
PIK3CA	0	27	0	0	0	0	27
BRAF	2	21	0	0	0	0	22
CTNNB1, LOC126806658	0	22	0	0	0	0	22
HRAS, LRRC56	0	15	0	0	0	0	15
ERBB2	4	7	0	0	0	0	9
SMAD4	0	9	0	0	0	0	9
ALK	0	7	1	0	0	0	8
MAP2K1	0	8	0	0	0	0	8
MUC5AC	0	0	7	1	0	0	8
NFE2L2	0	8	0	0	0	0	8
NLRP3	0	0	8	0	0	0	8
ROS1	2	1	3	0	1	0	6
B2M	0	5	0	0	0	0	5
CDKN2A	0	5	0	0	0	0	5
FBXW7	0	5	0	0	0	0	5
FLT1	0	0	5	0	0	0	5
IDH1	0	5	0	0	0	0	5
NRAS	0	5	0	0	0	0	5
CDK4	0	4	0	0	0	0	4
FGFR2	0	4	0	0	0	0	4
MLH1	0	1	3	0	0	0	4
RIN3	0	0	4	0	0	0	4
ADAM19	0	0	3	0	0	0	3
ADGRG6	0	0	3	0	0	0	3
ARAF	0	3	0	0	0	0	3
DDR2	0	0	2	0	1	0	3
DNMT3A	0	3	0	0	0	0	3
FOXP2	0	0	3	0	0	0	3
FOXP4	0	0	3	0	0	0	3
GNAS	0	3	0	0	0	0	3
KRAS	1	2	0	0	0	1	3
MYC	0	3	0	0	0	0	3
PPP2R1A	0	3	0	0	0	0	3
PTCH1	0	0	2	1	0	0	3
RB1	1	0	1	0	1	0	3
TLR4	0	0	2	1	0	0	3
ADAMTSL3	0	0	2	0	0	0	2
AKT1	0	1	1	0	0	0	2
APC	0	1	1	0	0	0	2
CD163	0	0	2	0	0	0	2
FGF10	1	0	1	0	0	0	2
HTR4	0	0	1	1	0	0	2
IREB2	0	0	2	0	0	0	2
RAF1	0	2	0	0	0	0	2
RHOA	0	2	0	0	0	0	2
STK11	0	2	0	0	0	0	2
U2AF1	0	2	0	0	0	0	2
ACTA2, PLAG1	0	1	0	0	0	0	1
ALX1	0	0	1	0	0	0	1
CDK12	0	1	0	0	0	0	1
CHRNA3	0	0	1	0	0	0	1
CHRNA3, CHRNA5	0	0	1	0	0	0	1
CHRNA5	0	0	1	0	0	0	1
CHRNB4	0	0	1	0	0	0	1
EPHA5	0	1	0	0	0	0	1
FAM13A	0	0	1	0	0	0	1
FGFR3	0	1	0	0	0	0	1
FLT1, LOC124849303	0	0	1	0	0	0	1
FOXP4, LOC129996415	0	0	1	0	0	0	1
FOXP4, LOC129996416	0	0	1	0	0	0	1
FPR2	0	0	1	0	0	0	1
LOC110006318, STK11	0	0	1	0	0	0	1
LOC126860749, TLR4	0	0	1	0	0	0	1
LOC126861112, MUC5AC	0	0	1	0	0	0	1
LOC130002133, PTCH1	0	0	1	0	0	0	1
NKX2-1, SFTA3	0	0	0	0	1	0	1
PACRG, PRKN	1	0	0	0	0	0	1
PITX2	0	0	1	0	0	0	1
PTEN	0	0	1	0	0	0	1
PTPN11	0	1	0	0	0	0	1
SLC22A18	0	0	1	0	0	0	1
SOS1	0	1	0	0	0	0	1
TGFB2	0	0	1	0	0	0	1

Submitter and significance breakdown #

Total submitters: 9

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Submitter	pathogenic	likely pathogenic	uncertain significance	likely benign	benign	not provided	total
Database of Curated Mutations (DoCM)	0	385	0	0	0	1	386
Liquid Biopsy and Cancer Interception Group, Pfizer-University of Granada-Junta de Andalucía Centre for Genomics and Oncological Research	9	1	83	4	4	0	101
Key Laboratory of Carcinogenesis and Cancer Invasion, Central South University	0	31	0	0	0	0	31
OMIM	6	0	0	0	0	0	6
Thoracic and Gastrointestinal Oncology Branch/CCR/NCI, NIH	1	2	0	0	0	0	3
3DMed Clinical Laboratory Inc	2	0	1	0	0	0	3
Salgia Laboratory, City of Hope	2	0	0	0	0	0	2
Molecular Diagnostics, Rajiv Gandhi Cancer Institute & Research Center	0	1	0	0	0	0	1
Genomic Medicine Laboratory, University of Vermont Medical Center	1	0	0	0	0	0	1

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