Variants studied for Prostate cancer

Minimum submission review status:		Collection method:
Minimum conflict level: Report conflict between different conditions
Gene type: Distinguish antisense genes from sense genes
Show significances as they were submitted (without aggregation into standard terms)
		ClinVar version:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic	likely pathogenic	uncertain significance	likely benign	benign	total
51	8	647	15	26	746

Gene and significance breakdown #

Total genes and gene combinations: 463

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Gene or gene combination	pathogenic	likely pathogenic	uncertain significance	likely benign	benign	total
SPOP	0	1	162	0	0	162
CDH1	0	0	2	10	23	35
POLK	21	0	0	0	0	21
AR	12	1	2	0	0	15
BRCA2	8	1	3	0	0	12
CHEK2	5	1	5	0	0	11
TP53	1	0	5	0	0	6
HOXB13	0	0	3	2	0	5
MAPT	0	0	3	0	0	3
MXI1	3	0	0	0	0	3
NBN	0	0	2	1	0	3
PARD3	0	0	3	0	0	3
WDFY3	0	1	2	0	0	3
ABCC4	0	0	2	0	0	2
AR, LOC109504725	1	0	1	0	0	2
ATM	0	1	1	0	0	2
BRCA1	0	0	1	1	0	2
COG1	0	0	2	0	0	2
KDM6A	0	0	2	0	0	2
KIF16B	0	0	2	0	0	2
KPRP	0	0	2	0	0	2
LRP1B	0	0	2	0	0	2
MACF1	0	0	2	0	0	2
MSR1	0	0	2	0	0	2
SCRN1	0	0	2	0	0	2
SEZ6L	0	0	2	0	0	2
VCAN	0	0	2	0	0	2
ABCA3	0	0	1	0	0	1
ABCE1	0	0	1	0	0	1
ABCF3	0	0	1	0	0	1
ABCG4	0	0	1	0	0	1
ABTB3	0	0	1	0	0	1
ACRV1, CHEK1	0	0	1	0	0	1
ADAMTS3	0	0	1	0	0	1
ADAT1	0	0	1	0	0	1
ADRM1	0	0	1	0	0	1
AGBL4, BEND5	0	0	1	0	0	1
AGPAT2	0	0	1	0	0	1
AHRR, PDCD6-AHRR	0	0	1	0	0	1
AIFM1, RAB33A	0	0	1	0	0	1
AKAP1	0	0	1	0	0	1
AKR1C3, LOC121366038	0	0	1	0	0	1
ALDH5A1	0	0	1	0	0	1
ALDH9A1	0	0	1	0	0	1
ANKRD12	0	0	1	0	0	1
ANO9	0	0	1	0	0	1
AP3B1	0	0	1	0	0	1
ARAP3	0	0	1	0	0	1
ARFGEF1-DT, CPA6	0	0	1	0	0	1
ARHGAP20	0	0	1	0	0	1
ARHGAP44, MYOCD	0	0	1	0	0	1
ARHGEF15	0	0	1	0	0	1
ARHGEF25	0	0	1	0	0	1
ARHGEF40	0	0	1	0	0	1
ARMC12	0	0	1	0	0	1
ARPP21	0	0	1	0	0	1
ASIC2	0	0	1	0	0	1
ASPRV1, LOC122757966	0	0	1	0	0	1
ATG13	0	0	1	0	0	1
ATL3, LOC126861231	0	0	1	0	0	1
ATP1A1	0	0	1	0	0	1
ATP2B4	0	0	1	0	0	1
ATP6V0A1	0	0	1	0	0	1
B3GALT1	0	0	1	0	0	1
BABAM2	0	0	1	0	0	1
BICRAL	0	0	1	0	0	1
BLTP2	0	0	1	0	0	1
BNIP5	0	0	1	0	0	1
BRF2	0	0	1	0	0	1
BTBD16	0	0	1	0	0	1
C10orf12, LCOR	0	0	1	0	0	1
C2CD6	0	0	1	0	0	1
C3AR1	0	0	1	0	0	1
C5	0	0	1	0	0	1
C8orf44-SGK3, SGK3	0	0	1	0	0	1
CABIN1	0	0	1	0	0	1
CACNA1D, LOC129936904	0	0	1	0	0	1
CADM3	0	0	1	0	0	1
CADPS	0	0	1	0	0	1
CAND1	0	0	1	0	0	1
CAPN6, LOC126863302	0	0	1	0	0	1
CASK, GPR82	0	0	1	0	0	1
CASR	0	0	1	0	0	1
CBX7	0	0	1	0	0	1
CBY1	0	0	1	0	0	1
CCDC171	0	0	1	0	0	1
CCNO-DT, DHX29	0	0	1	0	0	1
CD2	0	0	1	0	0	1
CD244	0	0	1	0	0	1
CD2AP	0	0	1	0	0	1
CDH1, LOC130059290	0	0	0	0	1	1
CDH3	0	0	1	0	0	1
CDKN2AIP	0	0	1	0	0	1
CERS3	0	0	1	0	0	1
CFAP43	0	0	1	0	0	1
CFAP65	0	0	1	0	0	1
CHAC1	0	0	1	0	0	1
CHAF1B, LOC126653361	0	0	1	0	0	1
CHD2	0	0	1	0	0	1
CHGB	0	0	1	0	0	1
CHIC1	0	0	1	0	0	1
CKAP5	0	0	1	0	0	1
CLPTM1L	0	0	1	0	0	1
CNGA1, LOC101927157	0	0	1	0	0	1
CNTFR	0	0	1	0	0	1
COL1A1	0	0	1	0	0	1
COL24A1	0	0	1	0	0	1
COL5A1	0	0	1	0	0	1
COPS6	0	0	1	0	0	1
CORIN	0	0	1	0	0	1
CPSF7	0	0	1	0	0	1
CRTC3	0	0	1	0	0	1
CRX	0	0	1	0	0	1
CSMD2	0	0	1	0	0	1
CTNNB1, LOC126806658	0	0	1	0	0	1
CTRB1	0	0	1	0	0	1
CTSE	0	0	1	0	0	1
CTTNBP2	0	0	1	0	0	1
CYSLTR1	0	0	1	0	0	1
DCHS2	0	0	1	0	0	1
DDX50	0	0	1	0	0	1
DDX60	0	0	1	0	0	1
DDX60L	0	0	1	0	0	1
DEAF1	0	0	1	0	0	1
DGAT2L6	0	0	1	0	0	1
DGCR6L	0	0	1	0	0	1
DHDH	0	0	1	0	0	1
DIS3L	0	0	1	0	0	1
DLAT	0	0	1	0	0	1
DLL1	0	0	1	0	0	1
DNAH3	0	0	1	0	0	1
DNAH8	0	0	1	0	0	1
DNAH9, LOC126862505	0	0	1	0	0	1
DNAJC3	0	0	1	0	0	1
DNAJC6	0	0	1	0	0	1
DOCK2	0	0	1	0	0	1
DOCK5	0	0	1	0	0	1
DPH7	0	0	1	0	0	1
DPPA4	0	0	1	0	0	1
DPYD	0	0	1	0	0	1
DSCAML1	0	0	1	0	0	1
DYM	0	0	1	0	0	1
E2F1	0	0	1	0	0	1
EFCAB6	0	0	1	0	0	1
EIF4G3	0	0	1	0	0	1
ELOA2, KATNAL2	0	0	1	0	0	1
EMILIN1	0	0	1	0	0	1
ENOX1	0	0	1	0	0	1
ENPP7	0	0	1	0	0	1
ENTPD3	0	0	1	0	0	1
ENTREP1	0	0	1	0	0	1
EPSTI1	0	0	1	0	0	1
ERBB2	0	0	1	0	0	1
ERBB3	0	0	1	0	0	1
ERBIN	0	0	1	0	0	1
EXOC2	0	0	1	0	0	1
EYA1	0	0	1	0	0	1
F2	0	0	1	0	0	1
F5	0	0	1	0	0	1
FAM13C	0	0	1	0	0	1
FAM83C	0	0	1	0	0	1
FANCA	0	0	1	0	0	1
FAXC	0	0	1	0	0	1
FBH1	0	0	1	0	0	1
FBN2	0	0	1	0	0	1
FBXL5	0	0	1	0	0	1
FGD2	0	0	1	0	0	1
FHIP1B	0	0	1	0	0	1
FPR1	0	0	1	0	0	1
FREM2	0	0	1	0	0	1
GABRB2	0	0	1	0	0	1
GABRG1	0	0	1	0	0	1
GAPDHS, TMEM147	0	0	1	0	0	1
GDF10	0	0	1	0	0	1
GET3	0	0	1	0	0	1
GFRA3	0	0	1	0	0	1
GLI1	0	0	1	0	0	1
GNGT1	0	0	1	0	0	1
GNPAT	0	0	1	0	0	1
GPHN, PIGH	0	0	1	0	0	1
GPR26	0	0	1	0	0	1
GPR55	0	0	1	0	0	1
GRID1	0	0	1	0	0	1
GRIN1	0	0	1	0	0	1
GRM8	0	0	1	0	0	1
GRWD1	0	0	1	0	0	1
GUSB	0	0	1	0	0	1
HEBP2	0	0	1	0	0	1
HEPACAM2	0	0	1	0	0	1
HHIPL1	0	0	1	0	0	1
HIF1A	0	0	1	0	0	1
HIPK4	0	0	1	0	0	1
HIRA	0	0	1	0	0	1
HLF	0	0	1	0	0	1
HMCN1	0	0	1	0	0	1
HPS3	0	0	1	0	0	1
HTR2C	0	0	1	0	0	1
HTR5A	0	0	1	0	0	1
IBTK	0	0	1	0	0	1
IFIH1	0	0	1	0	0	1
IFT43	0	0	1	0	0	1
IGF2R	0	0	1	0	0	1
IL33	0	0	1	0	0	1
IMPG2	0	0	1	0	0	1
ING4	0	0	1	0	0	1
INMT, INMT-MINDY4	0	0	1	0	0	1
INTS3	0	0	1	0	0	1
INTS8	0	0	1	0	0	1
IRGQ	0	0	1	0	0	1
ITGAD	0	0	1	0	0	1
ITGB6	0	0	1	0	0	1
ITIH5	0	0	1	0	0	1
ITPRIPL1	0	0	1	0	0	1
KAT7	0	0	1	0	0	1
KCNF1	0	0	1	0	0	1
KCNJ1	0	0	1	0	0	1
KCNJ4	0	0	1	0	0	1
KCNN3	0	0	1	0	0	1
KCNQ3	0	0	1	0	0	1
KCNQ5	0	0	1	0	0	1
KDM3A, LOC126806265	0	0	1	0	0	1
KDR	0	0	1	0	0	1
KIAA1755	0	0	1	0	0	1
KIF12	0	0	1	0	0	1
KIF5A	0	0	1	0	0	1
KIR2DL3	0	0	1	0	0	1
KIR3DL1	0	0	1	0	0	1
KIR3DL1, NLRP7	0	0	0	0	1	1
KLHL20	0	0	1	0	0	1
KMT5A	0	0	1	0	0	1
KNTC1	0	0	1	0	0	1
KRT1	0	0	1	0	0	1
KRT33A	0	0	1	0	0	1
KRT9	0	0	1	0	0	1
LAMA5	0	0	1	0	0	1
LARP1B	0	0	1	0	0	1
LMAN1L	0	0	1	0	0	1
LMLN	0	0	1	0	0	1
LMTK2	0	0	1	0	0	1
LOC101928034, S100A3	0	0	1	0	0	1
LOC108021846, SOX9	0	0	1	0	0	1
LOC126861022, PPRC1	0	0	1	0	0	1
LOC126862945, ZNF772	0	0	1	0	0	1
LOC130005185, TRIM34, TRIM5	0	0	1	0	0	1
LONP2	0	0	1	0	0	1
LRP1	0	0	1	0	0	1
LRP6	0	0	1	0	0	1
LRPAP1	0	0	1	0	0	1
LRRC37A3	0	0	1	0	0	1
MAD1L1	0	0	0	0	1	1
MAGI2	0	0	1	0	0	1
MAMDC2	0	0	1	0	0	1
MAML1	0	0	1	0	0	1
MAMLD1	0	0	1	0	0	1
MAPK10	0	0	1	0	0	1
MCC	0	0	1	0	0	1
MDP1, NEDD8-MDP1	0	0	1	0	0	1
MED1	0	0	1	0	0	1
MRPL46	0	0	1	0	0	1
MSH6	0	0	1	0	0	1
MTBP	0	0	1	0	0	1
MTHFR	0	0	1	0	0	1
MTNAP1	0	0	1	0	0	1
MUC17	0	0	1	0	0	1
MUC6	0	0	1	0	0	1
MXRA5	0	0	1	0	0	1
MYCBP2	0	0	1	0	0	1
MYH3	0	0	1	0	0	1
MYH8, MYHAS	0	0	1	0	0	1
MYLK	0	0	1	0	0	1
MYO16	0	0	1	0	0	1
MYO18A	0	0	1	0	0	1
MYO1A	0	0	1	0	0	1
MYOT, PKD2L2-DT	0	0	1	0	0	1
MYRF	0	0	1	0	0	1
NAPB	0	0	1	0	0	1
NECAP2	0	0	1	0	0	1
NEK9	0	0	1	0	0	1
NELL1	0	0	1	0	0	1
NEMF	0	0	1	0	0	1
NETO2	0	0	1	0	0	1
NFKBIA	0	0	0	1	0	1
NHS	0	0	1	0	0	1
NLRP1	0	0	1	0	0	1
NMD3	0	0	1	0	0	1
NOTCH3	0	0	1	0	0	1
NR3C1	0	0	1	0	0	1
NTN4	0	0	1	0	0	1
NWD1	0	0	1	0	0	1
OIT3	0	0	1	0	0	1
OLA1	0	0	1	0	0	1
OLFML3	0	0	1	0	0	1
OR14A16	0	0	1	0	0	1
OR1S2	0	0	1	0	0	1
OR2T1	0	0	1	0	0	1
OR2Z1	0	0	1	0	0	1
OR4C12	0	0	1	0	0	1
OR5AC2	0	0	1	0	0	1
OR5L1	0	0	1	0	0	1
OR6K2	0	0	1	0	0	1
OR8K3	0	0	1	0	0	1
OXA1L	0	0	1	0	0	1
PAK4	0	0	1	0	0	1
PALM2AKAP2	0	0	1	0	0	1
PCDHA1, PCDHA10, PCDHA2, PCDHA3, PCDHA4, PCDHA5, PCDHA6, PCDHA7, PCDHA8, PCDHA9, PCDHA@	0	0	1	0	0	1
PCDHB1, PCDHB@	0	0	1	0	0	1
PCNX1	0	0	1	0	0	1
PDE1C	0	0	1	0	0	1
PDE3A	0	0	1	0	0	1
PDE6B	0	0	1	0	0	1
PDE7B	0	0	1	0	0	1
PDK4	0	0	1	0	0	1
PDP2	0	0	1	0	0	1
PGPEP1	0	0	1	0	0	1
PHF2	0	0	1	0	0	1
PIK3CA	0	1	0	0	0	1
PIK3CG	0	0	1	0	0	1
PIK3R1	0	0	1	0	0	1
PITX2	0	0	1	0	0	1
PKD2L1	0	0	1	0	0	1
PKHD1	0	0	1	0	0	1
PLB1	0	0	1	0	0	1
PLCB4	0	0	1	0	0	1
PLEKHA4	0	0	1	0	0	1
PLEKHG1	0	0	1	0	0	1
PLEKHG4B	0	0	1	0	0	1
PODN	0	0	1	0	0	1
POLN	0	0	1	0	0	1
PPIP5K2	0	0	1	0	0	1
PPP1R3C	0	0	1	0	0	1
PPP2CA	0	0	1	0	0	1
PPP2R5C	0	0	1	0	0	1
PPP6R2	0	0	1	0	0	1
PREX2	0	0	1	0	0	1
PRH1, PRH1-PRR4, PRH1-TAS2R14, TAS2R20	0	0	1	0	0	1
PRKD1	0	0	1	0	0	1
PRPH2	0	0	1	0	0	1
PRSS22	0	0	1	0	0	1
PSMC1	0	0	1	0	0	1
PTPN21	0	0	1	0	0	1
PTPN3	0	0	1	0	0	1
PTPRD	0	0	1	0	0	1
PTPRN2	0	0	1	0	0	1
PYCR3	0	0	1	0	0	1
PYHIN1	0	0	1	0	0	1
RAB11FIP4	0	0	1	0	0	1
RAC2	0	0	1	0	0	1
RAD50	0	0	1	0	0	1
RAPGEFL1	0	0	1	0	0	1
RAPH1	0	0	1	0	0	1
RASAL2	0	0	1	0	0	1
RBAK, RBAK-RBAKDN	0	0	1	0	0	1
RCC2	0	0	1	0	0	1
RERGL	0	0	1	0	0	1
RHOBTB2	0	0	1	0	0	1
RIPOR3	0	0	1	0	0	1
RLIM	0	0	1	0	0	1
RNASEL	0	1	0	0	0	1
RPL10L	0	0	1	0	0	1
RPS6KC1	0	0	1	0	0	1
RPUSD1	0	0	1	0	0	1
RUBCNL	0	0	1	0	0	1
RUNDC1	0	0	1	0	0	1
SAFB2	0	0	1	0	0	1
SBNO1	0	0	1	0	0	1
SCNN1A	0	0	1	0	0	1
SCUBE3	0	0	1	0	0	1
SDK1	0	0	1	0	0	1
SERPINB13	0	0	1	0	0	1
SERPINB4	0	0	1	0	0	1
SF3B3	0	0	1	0	0	1
SGSM2	0	0	1	0	0	1
SHCBP1L	0	0	1	0	0	1
SI	0	0	1	0	0	1
SIGLEC6	0	0	1	0	0	1
SKIC3	0	0	1	0	0	1
SKIL	0	0	1	0	0	1
SLC13A3	0	0	1	0	0	1
SLC16A2	0	0	1	0	0	1
SLC25A22	0	0	1	0	0	1
SLC25A32	0	0	1	0	0	1
SLC25A47	0	0	1	0	0	1
SLC2A4RG	0	0	1	0	0	1
SLC30A2	0	0	1	0	0	1
SLC34A1	0	0	1	0	0	1
SLC35C1	0	0	1	0	0	1
SLC35G1	0	0	1	0	0	1
SLC46A3	0	0	1	0	0	1
SLC5A2	0	0	1	0	0	1
SLC5A7	0	0	1	0	0	1
SLC6A9	0	0	1	0	0	1
SLC8A3	0	0	1	0	0	1
SMARCC2	0	0	1	0	0	1
SMUG1	0	0	1	0	0	1
SORBS1	0	0	1	0	0	1
SORCS1	0	0	1	0	0	1
SPATA18	0	0	1	0	0	1
SPECC1L, SPECC1L-ADORA2A	0	0	1	0	0	1
SSBP2	0	0	1	0	0	1
ST8SIA6	0	0	1	0	0	1
STX8	0	0	1	0	0	1
STXBP1	0	0	1	0	0	1
SUFU	0	0	1	0	0	1
SV2B	0	0	1	0	0	1
SYCP2	0	0	1	0	0	1
SYNGR1	0	0	1	0	0	1
TAOK3	0	0	1	0	0	1
TEX14	0	0	1	0	0	1
TF	0	0	1	0	0	1
TG	0	0	1	0	0	1
TGFBR3	0	0	1	0	0	1
THBS3	0	0	1	0	0	1
TMCO5A	0	0	1	0	0	1
TMEM183A	0	0	1	0	0	1
TMEM230	0	0	1	0	0	1
TMEM94	0	0	1	0	0	1
TMPRSS2	0	0	1	0	0	1
TNFRSF8	0	0	1	0	0	1
TOPORS	0	0	1	0	0	1
TP63	0	0	1	0	0	1
TRIM28	0	0	1	0	0	1
TRIML1	0	0	1	0	0	1
TRIP12	0	0	1	0	0	1
TRPC1	0	0	1	0	0	1
TRPC4	0	0	1	0	0	1
TRPM3	0	0	1	0	0	1
TRRAP	0	0	1	0	0	1
TSHZ3	0	0	1	0	0	1
TSNAXIP1	0	0	1	0	0	1
TSPAN5	0	0	1	0	0	1
TUBB3	0	0	1	0	0	1
ULK2	0	0	1	0	0	1
UMODL1	0	0	1	0	0	1
UNC79	0	0	1	0	0	1
URB2	0	0	1	0	0	1
USF2	0	0	1	0	0	1
USH2A	0	0	1	0	0	1
USP28	0	0	1	0	0	1
USP48	0	0	1	0	0	1
UVRAG	0	0	1	0	0	1
VKORC1L1	0	0	1	0	0	1
VNN2	0	0	1	0	0	1
WDR49	0	0	1	0	0	1
WWC3	0	0	1	0	0	1
YTHDC2	0	0	1	0	0	1
ZDHHC8	0	0	1	0	0	1
ZKSCAN1	0	0	1	0	0	1
ZMAT3	0	0	1	0	0	1
ZNF100	0	0	1	0	0	1
ZNF136	0	0	1	0	0	1
ZNF184	0	0	1	0	0	1
ZNF224, ZNF225	0	0	1	0	0	1
ZNF287	0	0	1	0	0	1
ZNF304	0	0	1	0	0	1
ZNF419	0	0	1	0	0	1
ZNF431	0	0	1	0	0	1
ZNF48	0	0	1	0	0	1
ZNF534	0	0	1	0	0	1
ZNF560	0	0	1	0	0	1
ZNF717	0	0	1	0	0	1
ZNF776	0	0	1	0	0	1
ZP4	0	0	1	0	0	1
ZSCAN2	0	0	1	0	0	1

Submitter and significance breakdown #

Total submitters: 29

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Submitter	pathogenic	likely pathogenic	uncertain significance	likely benign	benign	total
Science for Life laboratory, Karolinska Institutet	0	0	407	0	0	407
Laboratory of Virology, Microbiology, Quality and Medical Biotechnologies, Faculty of Sciences and Techniques - Mohammedia, Hassan II University of Casablanca	0	0	160	0	0	160
Prostate Cancer Research Center, Institute of Biosciences and Medical Technology, University of Tampere	0	3	58	0	0	61
KCCC/NGS Laboratory, Kuwait Cancer Control Center	0	0	2	10	23	35
Tulane Cancer Center, Tulane University	21	0	0	0	0	21
Mendelics	13	1	3	0	2	19
OMIM	6	0	5	0	0	11
Department of Pathology and Laboratory Medicine, Sinai Health System	0	0	3	2	0	5
MGZ Medical Genetics Center	2	1	1	0	0	4
Genome-Nilou Lab	0	0	0	0	3	3
CSER _CC_NCGL, University of Washington	0	0	1	1	0	2
Centre for Mendelian Genomics, University Medical Centre Ljubljana	0	0	2	0	0	2
Genetics and Molecular Pathology, SA Pathology	1	1	0	0	0	2
Institute of Human Genetics, University of Leipzig Medical Center	2	0	0	0	0	2
Institute of Human Genetics, Clinical Exome/Genome Diagnostics Group, University Hospital Bonn	2	0	0	0	0	2
Laboratorio de Genetica e Diagnostico Molecular, Hospital Israelita Albert Einstein	0	0	2	0	0	2
Baylor Genetics	0	0	1	0	0	1
Soonchunhyang University Bucheon Hospital, Soonchunhyang University Medical Center	0	0	1	0	0	1
Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine	0	0	1	0	0	1
Anoual Laboratory of Radio-Immuno Analysis	1	0	0	0	0	1
3DMed Clinical Laboratory Inc	0	0	1	0	0	1
ACT Genomics,	0	0	0	1	0	1
Reproductive Health Research and Development, BGI Genomics	0	1	0	0	0	1
University Health Network, Princess Margaret Cancer Centre	1	0	0	0	0	1
Neuberg Centre For Genomic Medicine, NCGM	0	0	1	0	0	1
Lotan Lab, Johns Hopkins University	0	0	0	1	0	1
Clinical Genetics Laboratory, University Hospital Schleswig-Holstein	1	0	0	0	0	1
Biomedical Genomics and Oncogenetics Laboratory, Institut Pasteur de Tunis, University Tunis El Manar	1	0	0	0	0	1
Genomics England Pilot Project, Genomics England	0	1	0	0	0	1

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