ClinVar Miner

Variants studied for Type 2 diabetes mellitus

Coded as:
Minimum submission review status: Collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign affects association association not found likely risk allele protective risk factor not provided total
118 128 79 10 69 1 5 1 7 2 4 3 424

Gene and significance breakdown #

Total genes and gene combinations: 46
Download table as spreadsheet
Gene or gene combination pathogenic likely pathogenic uncertain significance likely benign benign affects association association not found likely risk allele protective risk factor not provided total
ABCC8 86 91 14 1 3 0 1 0 0 0 0 0 195
KCNJ11 5 25 4 0 3 0 1 1 4 0 0 1 43
RBPJ 0 0 6 0 17 0 0 0 0 0 0 0 23
WFS1 6 1 10 0 0 0 0 0 0 0 0 0 17
RBPJL 0 0 0 0 8 0 0 0 0 0 2 0 10
GCK 2 3 4 0 0 0 0 0 0 0 0 0 9
HNF1A 0 2 3 0 3 0 0 0 0 0 0 1 9
HNF1B 4 0 5 0 0 0 0 0 0 0 0 0 9
SLC2A2 2 0 3 0 2 1 0 0 0 0 0 0 8
AKT2 1 0 4 2 0 0 0 0 0 0 0 0 7
IRS1 2 0 1 3 1 0 0 0 0 0 0 0 7
ENPP1 1 1 3 0 1 0 0 0 0 0 0 0 6
HNF4A 1 0 3 2 1 0 0 0 0 0 0 0 6
C10orf67, PTF1A 0 0 0 0 5 0 0 0 0 0 0 0 5
LIPC 1 1 3 0 0 0 0 0 0 0 0 0 5
PPARG 2 0 0 0 0 0 3 0 0 0 0 0 5
PTF1A 0 0 0 0 5 0 0 0 0 0 0 0 5
RBPJL, SDC4 0 0 0 0 5 0 0 0 0 0 0 0 5
PDX1 0 0 3 0 1 0 0 0 0 0 0 0 4
PPP1R3A 0 0 1 0 3 0 0 0 0 0 0 0 4
ABCC8, LOC110121471 1 2 0 0 0 0 0 0 0 0 0 0 3
CDKAL1 0 0 2 0 0 0 0 0 0 0 0 1 3
INSR 1 0 2 0 0 0 0 0 0 0 0 0 3
IRS2 0 0 1 0 0 0 0 0 0 0 2 0 3
PAX4 1 0 0 0 2 0 0 0 0 0 0 0 3
SLC30A8 0 0 1 0 0 0 0 0 0 2 0 0 3
CD36 0 0 0 0 2 0 0 0 0 0 0 0 2
GPD2 1 0 1 0 0 0 0 0 0 0 0 0 2
INS, INS-IGF2 0 0 1 0 0 0 0 0 1 0 0 0 2
MATN4, RBPJL 0 0 0 0 2 0 0 0 0 0 0 0 2
ABCC8, KCNJ11 0 0 0 0 1 0 0 0 0 0 0 0 1
ACADS 0 0 0 1 0 0 0 0 0 0 0 0 1
C12orf43, HNF1A 0 0 0 0 1 0 0 0 0 0 0 0 1
CEL 0 0 1 0 0 0 0 0 0 0 0 0 1
GCGR 0 0 0 0 1 0 0 0 0 0 0 0 1
HNF1B, LOC126862549 0 1 0 0 0 0 0 0 0 0 0 0 1
INS 0 0 0 1 0 0 0 0 0 0 0 0 1
INS, INS-IGF2, TH 0 0 0 0 1 0 0 0 0 0 0 0 1
KLF11 0 0 0 0 0 0 0 0 1 0 0 0 1
LOC110121472, TCF7L2 0 0 0 0 0 0 0 0 1 0 0 0 1
LOC126807011, RBPJ 0 1 0 0 0 0 0 0 0 0 0 0 1
MAPK8IP1 0 0 1 0 0 0 0 0 0 0 0 0 1
NEUROD1 1 0 0 0 0 0 0 0 0 0 0 0 1
RBPJL, SLPI 0 0 0 0 1 0 0 0 0 0 0 0 1
SLC2A4 0 0 1 0 0 0 0 0 0 0 0 0 1
TCF7L2 0 0 1 0 0 0 0 0 0 0 0 0 1

Submitter and significance breakdown #

Total submitters: 41
Download table as spreadsheet
Submitter pathogenic likely pathogenic uncertain significance likely benign benign affects association association not found likely risk allele protective risk factor not provided total
Baylor Genetics 88 117 11 0 0 0 0 0 0 0 0 0 216
Clinical Genomics, Uppaluri K&H Personalized Medicine Clinic 0 2 18 2 16 0 2 1 6 0 0 0 47
Diabetes Molecular Genetics Section, Phoenix Epidemiology and Clinical Research Branch, National Institutes of Health 0 0 0 0 43 0 0 0 0 0 2 0 45
OMIM 14 0 4 0 1 0 0 0 0 2 2 0 23
Mendelics 6 4 6 0 0 0 0 0 0 0 0 0 16
New York Genome Center 1 0 13 0 0 0 0 0 0 0 0 0 14
Centre for Mendelian Genomics, University Medical Centre Ljubljana 1 0 5 1 0 0 0 0 0 0 0 0 7
Broad Center for Mendelian Genomics, Broad Institute of MIT and Harvard 0 0 2 3 0 0 0 0 0 0 0 0 5
Genome-Nilou Lab 0 0 0 0 5 0 0 0 0 0 0 0 5
Genomic Research Center, Shahid Beheshti University of Medical Sciences 1 1 1 0 1 0 0 0 0 0 0 0 4
Institute of Human Genetics, University of Leipzig Medical Center 0 1 3 0 0 0 0 0 0 0 0 0 4
Neuberg Centre For Genomic Medicine, NCGM 0 1 3 0 0 0 0 0 0 0 0 0 4
MGZ Medical Genetics Center 0 1 2 0 0 0 0 0 0 0 0 0 3
Genome Diagnostics Laboratory, University Medical Center Utrecht 0 0 0 2 1 0 0 0 0 0 0 0 3
Soonchunhyang University Bucheon Hospital, Soonchunhyang University Medical Center 0 0 2 1 0 0 0 0 0 0 0 0 3
Obstetrics and Gynaecology Department, Chinese University of Hong Kong 0 0 0 0 0 0 3 0 0 0 0 0 3
Genome Diagnostics Laboratory, Amsterdam University Medical Center 0 0 0 2 1 0 0 0 0 0 0 0 3
Centogene AG - the Rare Disease Company 0 0 2 0 0 0 0 0 0 0 0 0 2
Shenzhen Institute of Pediatrics, Shenzhen Children's Hospital 1 0 0 0 0 1 0 0 0 0 0 0 2
Bioscientia Institut fuer Medizinische Diagnostik GmbH, Sonic Healthcare 1 0 1 0 0 0 0 0 0 0 0 0 2
Genomics England Pilot Project, Genomics England 2 0 0 0 0 0 0 0 0 0 0 0 2
Faculté de Médecine, de Pharmacie et d'odontostomatologie, Université Cheikh Anta Diop 0 0 0 0 2 0 0 0 0 0 0 0 2
Fulgent Genetics, Fulgent Genetics 0 0 0 1 0 0 0 0 0 0 0 0 1
SNPedia 0 0 0 0 0 0 0 0 0 0 0 1 1
Center for Genomic Medicine, King Faisal Specialist Hospital and Research Center 0 0 1 0 0 0 0 0 0 0 0 0 1
Clinical Genomics Laboratory, Washington University in St. Louis 0 0 1 0 0 0 0 0 0 0 0 0 1
Foundation for Research in Genetics and Endocrinology, FRIGE's Institute of Human Genetics 0 0 1 0 0 0 0 0 0 0 0 0 1
Genetics and Molecular Pathology, SA Pathology 1 0 0 0 0 0 0 0 0 0 0 0 1
GenomeConnect, ClinGen 0 0 0 0 0 0 0 0 0 0 0 1 1
Juno Genomics, Hangzhou Juno Genomics, Inc 0 0 1 0 0 0 0 0 0 0 0 0 1
Seattle Children's Hospital Molecular Genetics Laboratory, Seattle Children's Hospital 0 0 1 0 0 0 0 0 0 0 0 0 1
Diagnostics Services (NGS), CSIR - Centre For Cellular And Molecular Biology 0 0 1 0 0 0 0 0 0 0 0 0 1
3billion 0 0 1 0 0 0 0 0 0 0 0 0 1
Department of Endocrinology, Antwerp University Hospital 1 0 0 0 0 0 0 0 0 0 0 0 1
GenomeConnect - Invitae Patient Insights Network 0 0 0 0 0 0 0 0 0 0 0 1 1
DASA 0 1 0 0 0 0 0 0 0 0 0 0 1
Molecular Genetics, Royal Melbourne Hospital 0 0 1 0 0 0 0 0 0 0 0 0 1
iDNA Genomics 0 0 0 0 0 0 0 0 1 0 0 0 1
Gemeinschaftspraxis fuer Humangenetik Dresden 0 0 1 0 0 0 0 0 0 0 0 0 1
Molecular Genetics and NGS Laboratory, Hospital Fundacion Valle Del Lili 0 1 0 0 0 0 0 0 0 0 0 0 1
Shanghai Diabetes Institute, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine 1 0 0 0 0 0 0 0 0 0 0 0 1

The information on this website is not intended for direct diagnostic use or medical decision-making without review by a genetics professional. Individuals should not change their health behavior solely on the basis of information contained on this website. Neither the University of Utah nor the National Institutes of Health independently verfies the submitted information. If you have questions about the information contained on this website, please see a health care professional.