ClinVar Miner

Variants in gene AIP

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Minimum submission review status: Collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign drug response not provided total
43 17 518 355 36 1 50 912

Condition and significance breakdown #

Total conditions: 11
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Condition pathogenic likely pathogenic uncertain significance likely benign benign drug response not provided total
not provided 29 5 375 248 17 0 0 654
Hereditary cancer-predisposing syndrome 14 4 321 230 13 0 0 575
Somatotroph adenoma 9 9 58 10 16 0 49 132
AIP-related disorder 0 0 8 12 2 0 0 22
Familial isolated pituitary adenoma 0 1 7 1 0 0 0 9
not specified 0 0 2 1 3 0 0 6
Pituitary adenoma predisposition 2 0 1 0 0 0 0 3
Pituitary dependent hypercortisolism; Somatotroph adenoma 0 0 2 1 0 0 0 3
Acroleukopathy, symmetric; Pituitary dependent hypercortisolism; Somatotroph adenoma 0 0 2 0 0 0 0 2
Dopamine agonists response 0 0 0 0 0 1 0 1
Pituitary dependent hypercortisolism 0 0 0 0 0 0 1 1

Submitter and significance breakdown #

Total submitters: 34
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Submitter pathogenic likely pathogenic uncertain significance likely benign benign drug response not provided total
Labcorp Genetics (formerly Invitae), Labcorp 29 3 355 243 11 0 0 641
Ambry Genetics 14 4 314 229 12 0 0 573
GeneDx 1 0 73 9 8 0 0 91
GeneReviews 0 5 0 1 0 0 49 55
Baylor Genetics 1 3 48 0 0 0 0 52
Illumina Laboratory Services, Illumina 1 0 7 9 15 0 0 32
Sema4, Sema4 0 0 12 13 2 0 0 27
PreventionGenetics, part of Exact Sciences 0 0 8 12 4 0 0 24
CeGaT Center for Human Genetics Tuebingen 2 2 2 6 3 0 0 15
St. Jude Molecular Pathology, St. Jude Children's Research Hospital 0 0 9 1 0 0 0 10
OMIM 9 0 0 0 0 0 0 9
Institute for Clinical Genetics, University Hospital TU Dresden, University Hospital TU Dresden 0 0 8 0 0 0 0 8
Breakthrough Genomics, Breakthrough Genomics 0 0 0 1 7 0 0 8
Fulgent Genetics, Fulgent Genetics 0 0 4 1 0 0 0 5
Eurofins Ntd Llc (ga) 0 0 3 0 0 0 0 3
Department of Pathology and Laboratory Medicine, Sinai Health System 0 0 1 2 0 0 0 3
Diagnostic Laboratory, Department of Genetics, University Medical Center Groningen 0 0 1 0 2 0 0 3
KCCC/NGS Laboratory, Kuwait Cancer Control Center 0 0 0 0 3 0 0 3
Genetic Services Laboratory, University of Chicago 0 0 1 1 0 0 0 2
Laboratory for Molecular Medicine, Mass General Brigham Personalized Medicine 0 0 1 0 1 0 0 2
Genome Diagnostics Laboratory, University Medical Center Utrecht 0 0 0 0 2 0 0 2
Korbonits Lab, Queen Mary University of London 0 1 1 0 0 0 0 2
Clinical Genetics DNA and cytogenetics Diagnostics Lab, Erasmus MC, Erasmus Medical Center 0 0 1 1 0 0 0 2
Revvity Omics, Revvity 0 0 1 0 0 0 0 1
Mendelics 0 0 1 0 0 0 0 1
Aziz Sancar Institute of Experimental Medicine, Istanbul University 1 0 0 0 0 1 0 1
Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital 0 0 0 0 1 0 0 1
Joint Genome Diagnostic Labs from Nijmegen and Maastricht, Radboudumc and MUMC+ 0 0 1 0 0 0 0 1
Institute of Human Genetics, University of Leipzig Medical Center 0 0 1 0 0 0 0 1
Juno Genomics, Hangzhou Juno Genomics, Inc 0 1 0 0 0 0 0 1
Genome Diagnostics Laboratory, Amsterdam University Medical Center 0 0 0 1 0 0 0 1
GenomeConnect - Invitae Patient Insights Network 0 0 0 0 0 0 1 1
Molecular Genetics, Labor Dr. Heidrich & Kollegen MVZ GmbH 0 0 1 0 0 0 0 1
Unidad de Genética Molecular HGU Elche, Hospital General Universitario de Elche 0 0 0 1 0 0 0 1

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