Variants in gene ARHGEF15

Minimum submission review status:		Collection method:
Minimum conflict level: Report conflict between different conditions
Gene type: Distinguish antisense genes from sense genes
Show significances as they were submitted (without aggregation into standard terms)
		ClinVar version:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic	likely pathogenic	uncertain significance	likely benign	benign	not provided	total
0	1	401	223	37	2	644

Condition and significance breakdown #

Total conditions: 6

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Condition	likely pathogenic	uncertain significance	likely benign	benign	not provided	total
Developmental and epileptic encephalopathy	1	353	209	37	0	600
not specified	0	86	4	0	0	90
not provided	0	9	13	19	2	42
ARHGEF15-related disorder	0	1	11	3	0	15
Prostate cancer	0	1	0	0	0	1
See cases	0	0	0	1	0	1

Submitter and significance breakdown #

Total submitters: 16

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Submitter	likely pathogenic	uncertain significance	likely benign	benign	not provided	total
Labcorp Genetics (formerly Invitae), Labcorp	0	353	211	37	0	601
Ambry Genetics	0	85	2	0	0	87
Breakthrough Genomics, Breakthrough Genomics	0	4	7	19	0	30
PreventionGenetics, part of Exact Sciences	0	1	11	3	0	15
GeneDx	0	0	1	3	0	4
Genetic Services Laboratory, University of Chicago	0	1	2	0	0	3
CeGaT Center for Human Genetics Tuebingen	0	0	3	0	0	3
GenomeConnect, ClinGen	0	0	0	0	2	2
New York Genome Center	0	2	0	0	0	2
OMIM	0	1	0	0	0	1
Revvity Omics, Revvity	0	1	0	0	0	1
Women's Health and Genetics/Laboratory Corporation of America, LabCorp	0	1	0	0	0	1
Science for Life laboratory, Karolinska Institutet	0	1	0	0	0	1
NeuroMeGen, Hospital Clinico Santiago de Compostela	1	0	0	0	0	1
Centre for Mendelian Genomics, University Medical Centre Ljubljana	0	0	0	1	0	1
Center for Genomics, Ann and Robert H. Lurie Children's Hospital of Chicago	0	1	0	0	0	1

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