ClinVar Miner

Variants in gene BARD1

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Minimum submission review status: Collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign risk factor not provided total
526 272 2427 1486 696 1 15 4387

Condition and significance breakdown #

Total conditions: 26
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Condition pathogenic likely pathogenic uncertain significance likely benign benign risk factor not provided total
Familial cancer of breast 435 201 1856 978 624 0 10 3493
Hereditary cancer-predisposing syndrome 222 91 1570 973 31 0 0 2722
not provided 41 59 502 119 100 0 2 772
not specified 0 0 188 183 49 0 0 391
Hereditary breast ovarian cancer syndrome 11 10 38 26 24 0 0 107
BARD1-related disorder 4 1 40 43 0 0 0 88
Malignant tumor of breast 13 5 34 18 5 0 3 77
BARD1-related cancer predisposition 7 1 39 12 1 0 0 60
Breast and/or ovarian cancer 3 1 16 14 1 0 0 35
Gastric cancer 19 0 0 0 0 0 0 19
Hereditary cancer 0 0 5 7 0 0 0 12
Ovarian cancer 0 4 0 0 5 0 0 9
Breast neoplasm 1 0 5 2 0 0 0 7
Triple-Negative Breast Cancer Finding 2 0 2 1 0 0 0 5
Familial ovarian cancer 0 0 3 1 0 0 0 4
Breast carcinoma 2 0 1 0 0 0 0 3
Carcinoma of colon 0 0 2 1 0 0 0 3
Familial pancreatic carcinoma 0 0 3 0 0 0 0 3
Breast cancer, susceptibility to 1 0 0 0 0 1 0 2
Endometrial carcinoma 1 0 0 0 0 0 0 1
Familial adenomatous polyposis 2 0 0 1 0 0 0 0 1
Hepatoblastoma 0 1 0 0 0 0 0 1
Lung cancer 0 0 0 1 0 0 0 1
Malignant tumor of thyroid gland 0 0 1 0 0 0 0 1
Multiple myeloma 0 1 0 0 0 0 0 1
Ovarian neoplasm 0 1 0 0 0 0 0 1

Submitter and significance breakdown #

Total submitters: 76
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Submitter pathogenic likely pathogenic uncertain significance likely benign benign risk factor not provided total
Labcorp Genetics (formerly Invitae), Labcorp 269 112 1782 841 45 0 0 3049
Ambry Genetics 203 69 1295 801 16 0 0 2384
Color Diagnostics, LLC DBA Color Health 72 21 698 378 22 0 0 1191
Myriad Genetics, Inc. 287 58 16 199 593 0 0 1153
GeneDx 21 38 412 142 104 0 0 717
Baylor Genetics 26 58 256 0 0 0 0 340
Quest Diagnostics Nichols Institute San Juan Capistrano 17 6 175 39 27 0 0 264
Women's Health and Genetics/Laboratory Corporation of America, LabCorp 17 10 144 68 12 0 0 251
Department of Pathology and Laboratory Medicine, Sinai Health System 19 3 148 62 7 0 0 239
Sema4, Sema4 5 11 98 56 12 0 0 182
Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital 6 3 52 56 10 0 0 127
PreventionGenetics, part of Exact Sciences 4 1 52 51 18 0 0 126
Mendelics 4 2 56 22 9 0 0 93
Fulgent Genetics, Fulgent Genetics 8 2 54 3 3 0 0 70
Counsyl 2 3 35 14 6 0 0 60
Illumina Laboratory Services, Illumina 0 0 36 11 9 0 0 55
National Health Laboratory Service, Universitas Academic Hospital and University of the Free State 2 0 9 16 24 0 0 51
KCCC/NGS Laboratory, Kuwait Cancer Control Center 3 0 22 5 19 0 0 49
Breakthrough Genomics, Breakthrough Genomics 0 0 3 12 32 0 0 47
CeGaT Center for Human Genetics Tuebingen 6 6 10 21 3 0 0 46
University of Washington Department of Laboratory Medicine, University of Washington 0 1 0 32 0 0 0 33
CHEO Genetics Diagnostic Laboratory, Children's Hospital of Eastern Ontario 0 0 16 14 1 0 0 31
ARUP Laboratories, Molecular Genetics and Genomics, ARUP Laboratories 1 0 5 6 15 0 0 27
Institute for Biomarker Research, Medical Diagnostic Laboratories, L.L.C. 1 1 14 6 4 0 0 26
Genetic Services Laboratory, University of Chicago 1 0 11 6 7 0 0 25
Revvity Omics, Revvity 7 6 12 0 0 0 0 25
Institute for Clinical Genetics, University Hospital TU Dresden, University Hospital TU Dresden 4 3 15 2 0 0 0 24
St. Jude Molecular Pathology, St. Jude Children's Research Hospital 1 2 17 0 0 0 0 20
MGZ Medical Genetics Center 2 3 14 0 0 0 0 19
Laboratory for Genotyping Development, RIKEN 19 0 0 0 0 0 0 19
German Consortium for Hereditary Breast and Ovarian Cancer, University Hospital Cologne 1 5 4 6 0 0 0 16
GeneKor MSA 1 1 13 0 0 0 0 15
Cancer Genomics Group, Japanese Foundation For Cancer Research 2 3 7 1 0 0 0 13
Institute of Human Genetics, University of Leipzig Medical Center 4 1 4 1 2 0 0 12
GenomeConnect - Invitae Patient Insights Network 0 0 0 0 0 0 12 12
Molecular Diagnostics Laboratory, Catalan Institute of Oncology 0 2 4 4 0 0 0 10
Laboratory of Molecular Epidemiology of Birth Defects, West China Second University Hospital, Sichuan University 0 4 0 0 5 0 0 9
Centre for Mendelian Genomics, University Medical Centre Ljubljana 2 0 5 0 1 0 0 8
BRCAlab, Lund University 7 0 0 0 0 0 0 7
Institute of Medical Genetics and Applied Genomics, University Hospital Tübingen 4 2 0 0 0 0 0 6
Clinical Genetics Laboratory, Skane University Hospital Lund 5 0 1 0 0 0 0 6
King Laboratory, University of Washington 5 0 0 0 0 0 0 5
Mayo Clinic Laboratories, Mayo Clinic 0 1 4 0 0 0 0 5
Laboratory of Diagnostic Genome Analysis, Leiden University Medical Center (LUMC) 0 0 1 2 2 0 0 5
Lab. Molecular Oncology, VUB, Free University of Brussels 2 0 2 1 0 0 0 5
Cancer Genetics Service, National Cancer Centre Singapore 1 1 3 0 0 0 0 5
Neuberg Centre For Genomic Medicine, NCGM 0 1 4 0 0 0 0 5
Genome Diagnostics Laboratory, Amsterdam University Medical Center 0 0 0 2 2 0 0 4
CZECANCA consortium 3 1 0 0 0 0 0 4
Laboratorio de Genetica e Diagnostico Molecular, Hospital Israelita Albert Einstein 1 0 3 0 0 0 0 4
Department of Clinical Genetics, Copenhagen University Hospital, Rigshospitalet 0 3 0 0 0 0 0 3
Laboratory for Molecular Medicine, Mass General Brigham Personalized Medicine 0 0 0 0 3 0 0 3
HudsonAlpha Institute for Biotechnology, HudsonAlpha Institute for Biotechnology 2 1 0 0 0 0 0 3
GenomeConnect, ClinGen 0 0 0 0 0 0 3 3
Juno Genomics, Hangzhou Juno Genomics, Inc 1 2 0 0 0 0 0 3
Clinical Genetics DNA and cytogenetics Diagnostics Lab, Erasmus MC, Erasmus Medical Center 0 0 0 3 0 0 0 3
Zotz-Klimas Genetics Lab, MVZ Zotz Klimas 0 0 3 0 0 0 0 3
Medical Genetics Laboratory, Umraniye Training and Research Hospital, University of Health Sciences 2 0 1 0 0 0 0 3
Genomics Laboratory, Virgen de la Arrixaca University Clinical Hospital 0 0 2 0 0 0 0 2
Diagnostic Laboratory, Department of Genetics, University Medical Center Groningen 0 0 1 1 0 0 0 2
Hauer Lab, Department Of Pediatric Oncology, Technical University Munich 2 0 0 0 0 0 0 2
Department of Human Genetics, Hannover Medical School 0 0 2 0 0 0 0 2
OMIM 0 0 0 0 0 1 0 1
Institute of Human Genetics, University of Goettingen 0 0 1 0 0 0 0 1
Eurofins Ntd Llc (ga) 0 0 0 1 0 0 0 1
Genomic Research Center, Shahid Beheshti University of Medical Sciences 0 0 0 1 0 0 0 1
Institute of Human Genetics, FAU Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg 0 1 0 0 0 0 0 1
Vantari Genetics 0 0 0 0 1 0 0 1
Undiagnosed Diseases Network, NIH 0 1 0 0 0 0 0 1
Center of Medical Genetics and Primary Health Care 0 0 0 0 1 0 0 1
Yang An-Suei Laboratory, Academia Sinica 1 0 0 0 0 0 0 1
Xiao lab, Department of Pathology, Memorial Sloan Kettering Cancer Center 0 1 0 0 0 0 0 1
Dr. med. U. Finckh, Human Genetics, Eurofins MVZ 1 0 0 0 0 0 0 1
Genomics, Clalit Research Institute, Clalit Health Care 0 1 0 0 0 0 0 1
Molecular Oncology - Human Genetics Lab, University of Sao Paulo 0 1 0 0 0 0 0 1
Diagnostics Centre, Carl Von Ossietzky University Oldenburg 1 0 0 0 0 0 0 1

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