ClinVar Miner

Variants in gene BARD1

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Minimum submission review status: Collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign risk factor not provided total
471 241 2244 1172 148 1 15 3880

Condition and significance breakdown #

Total conditions: 26
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Condition pathogenic likely pathogenic uncertain significance likely benign benign risk factor not provided total
Familial cancer of breast 397 182 1743 815 58 0 10 3059
Hereditary cancer-predisposing syndrome 187 75 1421 753 32 0 0 2376
not provided 35 47 422 108 99 0 2 675
not specified 0 0 166 156 48 0 0 341
Hereditary breast ovarian cancer syndrome 7 5 24 17 24 0 0 76
Malignant tumor of breast 11 3 34 18 5 0 3 73
Breast and/or ovarian cancer 3 1 16 14 1 0 0 35
BARD1-related condition 2 0 19 0 0 0 0 21
Gastric cancer 19 0 0 0 0 0 0 19
Ovarian cancer 0 4 0 0 5 0 0 9
Breast neoplasm 1 0 5 2 0 0 0 7
Hereditary cancer 0 0 2 3 0 0 0 5
Triple-Negative Breast Cancer Finding 2 0 2 1 0 0 0 5
Familial ovarian cancer 0 0 3 1 0 0 0 4
Breast carcinoma 2 0 1 0 0 0 0 3
Carcinoma of colon 0 0 2 1 0 0 0 3
Familial pancreatic carcinoma 0 0 3 0 0 0 0 3
Inborn genetic diseases 0 0 3 0 0 0 0 3
Breast cancer, susceptibility to 1 0 0 0 0 1 0 2
Endometrial carcinoma 1 0 0 0 0 0 0 1
Familial adenomatous polyposis 2 0 0 1 0 0 0 0 1
Hepatoblastoma 0 1 0 0 0 0 0 1
Lung cancer 0 0 0 1 0 0 0 1
Malignant tumor of thyroid gland 0 0 1 0 0 0 0 1
Multiple myeloma 0 1 0 0 0 0 0 1
Neoplasm of ovary 0 1 0 0 0 0 0 1

Submitter and significance breakdown #

Total submitters: 71
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Submitter pathogenic likely pathogenic uncertain significance likely benign benign risk factor not provided total
Invitae 241 100 1677 773 44 0 0 2835
Ambry Genetics 165 58 1180 574 16 0 0 1993
Color Diagnostics, LLC DBA Color Health 70 18 671 361 23 0 0 1143
GeneDx 22 31 343 142 104 0 0 642
Myriad Genetics, Inc. 265 57 17 24 12 0 0 375
Baylor Genetics 24 54 165 0 0 0 0 243
Women's Health and Genetics/Laboratory Corporation of America, LabCorp 12 7 129 55 12 0 0 215
Quest Diagnostics Nichols Institute San Juan Capistrano 11 4 123 39 27 0 0 204
Sema4, Sema4 5 11 98 56 12 0 0 182
Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital 4 2 40 39 8 0 0 93
Mendelics 4 2 57 16 9 0 0 88
Department of Pathology and Laboratory Medicine, Sinai Health System 5 0 50 22 5 0 0 82
Preventiongenetics, part of Exact Sciences 2 0 32 9 18 0 0 61
Counsyl 2 3 35 14 6 0 0 60
Illumina Laboratory Services, Illumina 0 0 37 11 9 0 0 56
National Health Laboratory Service, Universitas Academic Hospital and University of the Free State 2 0 9 16 24 0 0 51
KCCC/NGS Laboratory, Kuwait Cancer Control Center 2 0 15 5 17 0 0 39
Fulgent Genetics, Fulgent Genetics 5 1 25 3 3 0 0 37
University of Washington Department of Laboratory Medicine, University of Washington 0 1 0 32 0 0 0 33
CHEO Genetics Diagnostic Laboratory, Children's Hospital of Eastern Ontario 0 0 16 14 1 0 0 31
CeGaT Center for Human Genetics Tuebingen 5 4 10 8 4 0 0 31
Genetic Services Laboratory, University of Chicago 1 0 11 6 7 0 0 25
Revvity Omics, Revvity Omics 7 6 12 0 0 0 0 25
Institute for Clinical Genetics, University Hospital TU Dresden, University Hospital TU Dresden 4 3 15 2 0 0 0 24
ARUP Laboratories, Molecular Genetics and Genomics, ARUP Laboratories 1 0 2 5 14 0 0 22
MGZ Medical Genetics Center 2 3 14 0 0 0 0 19
Laboratory for Genotyping Development, RIKEN 19 0 0 0 0 0 0 19
GeneKor MSA 1 1 13 0 0 0 0 15
Institute for Biomarker Research, Medical Diagnostic Laboratories, L.L.C. 0 0 7 3 4 0 0 14
St. Jude Molecular Pathology, St. Jude Children's Research Hospital 0 2 11 0 0 0 0 13
Cancer Genomics Group, Japanese Foundation For Cancer Research 2 2 7 1 0 0 0 12
GenomeConnect - Invitae Patient Insights Network 0 0 0 0 0 0 12 12
Institute of Human Genetics, University of Leipzig Medical Center 3 0 5 1 2 0 0 11
Laboratory of Molecular Epidemiology of Birth Defects, West China Second University Hospital, Sichuan University 0 4 0 0 5 0 0 9
Centre for Mendelian Genomics, University Medical Centre Ljubljana 2 0 5 0 1 0 0 8
BRCAlab, Lund University 7 0 0 0 0 0 0 7
King Laboratory, University of Washington 5 0 0 0 0 0 0 5
Institute of Medical Genetics and Applied Genomics, University Hospital Tübingen 4 1 0 0 0 0 0 5
Laboratory of Diagnostic Genome Analysis, Leiden University Medical Center (LUMC) 0 0 1 2 2 0 0 5
Lab. Molecular Oncology, VUB, Free University of Brussels 2 0 2 1 0 0 0 5
Cancer Genetics Service, National Cancer Centre Singapore 1 1 3 0 0 0 0 5
Genome Diagnostics Laboratory, Amsterdam University Medical Center 0 0 0 2 2 0 0 4
CZECANCA consortium 3 1 0 0 0 0 0 4
Neuberg Supratech Reference Laboratories Pvt Ltd, Neuberg Centre for Genomic Medicine 0 0 4 0 0 0 0 4
Laboratorio de Genetica e Diagnostico Molecular, Hospital Israelita Albert Einstein 1 0 3 0 0 0 0 4
Laboratory for Molecular Medicine, Mass General Brigham Personalized Medicine 0 0 0 0 3 0 0 3
Mayo Clinic Laboratories, Mayo Clinic 0 0 3 0 0 0 0 3
HudsonAlpha Institute for Biotechnology, HudsonAlpha Institute for Biotechnology 2 1 0 0 0 0 0 3
GenomeConnect, ClinGen 0 0 0 0 0 0 3 3
Clinical Genetics DNA and cytogenetics Diagnostics Lab, Erasmus MC, Erasmus Medical Center 0 0 0 3 0 0 0 3
German Consortium for Hereditary Breast and Ovarian Cancer, University Hospital Cologne 0 1 1 1 0 0 0 3
Zotz-Klimas Genetics Lab, MVZ Zotz Klimas 0 0 3 0 0 0 0 3
Medical Genetics Laboratory, Umraniye Training and Research Hospital, University of Health Sciences 2 0 1 0 0 0 0 3
Genomics Laboratory, Virgen de la Arrixaca University Clinical Hospital 0 0 2 0 0 0 0 2
Diagnostic Laboratory, Department of Genetics, University Medical Center Groningen 0 0 1 1 0 0 0 2
Hauer Lab, Department Of Pediatric Oncology, Technical University Munich 2 0 0 0 0 0 0 2
OMIM 0 0 0 0 0 1 0 1
Cincinnati Children's Hospital Medical Center Genetics and Genomics Diagnostic Laboratory, Cincinnati Children's Hospital Medical Center 0 0 0 0 1 0 0 1
Institute of Human Genetics, University of Goettingen 0 0 1 0 0 0 0 1
Eurofins Ntd Llc (ga) 0 0 0 1 0 0 0 1
Genomic Research Center, Shahid Beheshti University of Medical Sciences 0 0 0 1 0 0 0 1
Institute of Human Genetics, FAU Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg 0 1 0 0 0 0 0 1
Vantari Genetics 0 0 0 0 1 0 0 1
Undiagnosed Diseases Network, NIH 0 1 0 0 0 0 0 1
Center of Medical Genetics and Primary Health Care 0 0 0 0 1 0 0 1
Yang An-Suei Laboratory, Academia Sinica 1 0 0 0 0 0 0 1
Xiao lab, Department of Pathology, Memorial Sloan Kettering Cancer Center 0 1 0 0 0 0 0 1
Dr. med. U. Finckh, Human Genetics, Eurofins MVZ 1 0 0 0 0 0 0 1
Department of Human Genetics, Hannover Medical School 0 0 1 0 0 0 0 1
Molecular Oncology - Human Genetics Lab, University of Sao Paulo 0 1 0 0 0 0 0 1
Diagnostics Centre, Carl Von Ossietzky University Oldenburg 1 0 0 0 0 0 0 1

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