Variants in gene IRAK3 - ClinVar Miner

Minimum submission review status:		Collection method:
Minimum conflict level: Report conflict between different conditions
Gene type: Distinguish antisense genes from sense genes
Show significances as they were submitted (without aggregation into standard terms)
		ClinVar version:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic	likely pathogenic	uncertain significance	likely benign	benign	likely risk allele	risk factor	total
0	2	58	13	6	1	3	80

Condition and significance breakdown #

Total conditions: 7

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Condition	likely pathogenic	uncertain significance	likely benign	benign	likely risk allele	risk factor	total
not specified	0	53	2	0	0	0	55
not provided	2	4	5	2	0	0	13
IRAK3-related disorder	0	0	6	5	0	0	11
Asthma-related traits, susceptibility to, 5	0	0	0	0	0	2	2
Hirschsprung disease, susceptibility to, 1	0	1	0	0	0	0	1
Multisystem inflammatory syndrome in children	0	0	0	0	0	1	1
Susceptibility to severe COVID-19	0	0	0	0	1	0	1

Submitter and significance breakdown #

Total submitters: 10

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Submitter	likely pathogenic	uncertain significance	likely benign	benign	likely risk allele	risk factor	total
Ambry Genetics	0	53	2	0	0	0	55
PreventionGenetics, part of Exact Sciences	0	0	6	5	0	0	11
Labcorp Genetics (formerly Invitae), Labcorp	0	0	4	2	0	0	6
GeneDx	2	3	0	0	0	0	5
Breakthrough Genomics, Breakthrough Genomics	0	0	1	2	0	0	3
OMIM	0	0	0	0	0	2	2
Al Jalila Children’s Genomics Center, Al Jalila Childrens Speciality Hospital	0	0	0	0	1	1	2
Clinical Genomics Laboratory, Washington University in St. Louis	0	1	0	0	0	0	1
Department of Genetics, Reproduction and Fetal Medicine., Institute of Biomedicine of Seville (IBIS), University Hospital Virgen del Rocío/CSIC/University of Seville.	0	1	0	0	0	0	1
CeGaT Center for Human Genetics Tuebingen	0	0	1	0	0	0	1

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