ClinVar Miner

Variants in gene KRAS

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Minimum submission review status: Collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign association not provided total
58 65 249 165 46 1 17 498

Condition and significance breakdown #

Total conditions: 69
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Condition pathogenic likely pathogenic uncertain significance likely benign benign association not provided total
RASopathy 24 15 62 67 10 0 1 174
not provided 37 17 44 52 33 0 0 169
Noonan syndrome 5 6 45 35 0 0 0 91
Prostate cancer, hereditary, 1 0 0 72 0 0 0 0 72
Cardiovascular phenotype 2 2 7 45 3 0 0 59
not specified 2 0 23 23 13 0 3 55
Noonan syndrome 3 14 8 2 1 1 0 1 26
KRAS-related disorder 7 2 3 8 0 0 0 20
Non-small cell lung carcinoma 14 4 0 0 0 0 0 18
Cardio-facio-cutaneous syndrome 1 1 10 5 0 0 0 17
Familial cancer of breast; Noonan syndrome 3; Linear nevus sebaceous syndrome; Toriello-Lacassie-Droste syndrome; Cerebral arteriovenous malformation; Malignant tumor of urinary bladder; Autoimmune lymphoproliferative syndrome type 4; Acute myeloid leukemia; Cardiofaciocutaneous syndrome 2; Familial pancreatic carcinoma; Gastric cancer; Lung cancer 3 0 11 0 0 0 0 14
Cardiofaciocutaneous syndrome 2 10 2 1 0 0 0 0 13
Noonan syndrome and Noonan-related syndrome 2 0 2 2 4 0 0 10
Familial cancer of breast; Noonan syndrome 3; Linear nevus sebaceous syndrome; Toriello-Lacassie-Droste syndrome; Cerebral arteriovenous malformation; Malignant tumor of urinary bladder; Carcinoma of pancreas; Autoimmune lymphoproliferative syndrome type 4; Acute myeloid leukemia; Cardiofaciocutaneous syndrome 2; Gastric cancer; Lung cancer 0 0 2 6 0 0 0 8
Inborn genetic diseases 3 1 3 0 0 0 0 7
Noonan syndrome; Cardio-facio-cutaneous syndrome 4 3 0 0 0 0 0 7
Vascular malformation 2 4 1 0 0 0 0 7
Encephalocraniocutaneous lipomatosis 1 0 0 0 0 0 5 6
Autoimmune lymphoproliferative syndrome type 4 4 1 1 0 0 0 0 5
Juvenile myelomonocytic leukemia 4 1 0 0 0 0 0 5
OCULOECTODERMAL SYNDROME, SOMATIC 4 0 0 0 0 0 0 4
Carcinoma of pancreas 2 1 0 0 0 0 0 3
Cerebral arteriovenous malformation 3 0 0 0 0 0 0 3
Linear nevus sebaceous syndrome 2 1 0 0 0 0 0 3
Lung cancer 0 3 0 0 0 0 0 3
Multiple myeloma 1 2 0 0 0 0 0 3
Nevus sebaceous 3 0 0 0 0 0 0 3
Noonan syndrome 1 2 0 0 0 0 0 1 3
Acute myeloid leukemia 2 0 0 0 0 0 0 2
Endometrial carcinoma 0 0 0 0 0 0 2 2
Familial pancreatic carcinoma 1 1 0 0 0 0 0 2
Gallbladder cancer 2 0 0 0 0 0 0 2
Gastric cancer 2 0 0 0 0 0 0 2
Malignant tumor of urinary bladder 2 0 0 0 0 0 0 2
Noonan syndrome 3; Autoimmune lymphoproliferative syndrome type 4; Acute myeloid leukemia; Cardiofaciocutaneous syndrome 2 1 1 0 0 0 0 0 2
Ovarian neoplasm 1 0 0 0 0 0 1 2
Sarcoma 0 0 0 0 0 0 2 2
Squamous cell lung carcinoma 1 0 1 0 0 0 0 2
Bladder cancer, transitional cell, somatic 1 0 0 0 0 0 0 1
Breast adenocarcinoma 1 0 0 0 0 0 0 1
Capillary Telangiectasia, Brain 1 0 0 0 0 0 0 1
Capillary malformation-arteriovenous malformation 1 1 0 0 0 0 0 0 1
Cardiofaciocutaneous syndrome 1 1 0 0 0 0 0 0 1
Chronic myelogenous leukemia, BCR-ABL1 positive 1 0 0 0 0 0 0 1
Classic Hodgkin lymphoma 0 0 1 0 0 0 0 1
Congenital Pulmonary Airway Malformations 1 0 0 0 0 0 0 1
Endometrial hyperplasia without atypia; Atypical endometrial hyperplasia 0 0 0 0 0 1 0 1
Epidermal nevus 1 0 0 0 0 0 0 1
Familial cancer of breast 0 0 0 0 0 0 1 1
Familial cancer of breast; Hereditary diffuse gastric adenocarcinoma; Lung carcinoma; Noonan syndrome 3; Linear nevus sebaceous syndrome; Cerebral arteriovenous malformation; Malignant tumor of urinary bladder; Carcinoma of pancreas; Autoimmune lymphoproliferative syndrome type 4; Acute myeloid leukemia; Cardiofaciocutaneous syndrome 2 1 0 0 0 0 0 0 1
Hereditary breast ovarian cancer syndrome 0 1 0 0 0 0 0 1
KRAS-related RASopathy 0 1 0 0 0 0 0 1
KRAS-related overgrowth 1 0 0 0 0 0 0 1
Lung adenocarcinoma 1 0 0 0 0 0 0 1
Lung carcinoma 1 0 0 0 0 0 0 1
Lung sarcomatoid carcinoma 1 0 0 0 0 0 0 1
Non-immune hydrops fetalis 0 1 0 0 0 0 0 1
Noonan syndrome 3; Cardiofaciocutaneous syndrome 2 1 0 0 0 0 0 0 1
Noonan syndrome 3; Linear nevus sebaceous syndrome; Autoimmune lymphoproliferative syndrome type 4; Acute myeloid leukemia; Cardiofaciocutaneous syndrome 2 0 0 1 0 0 0 0 1
Noonan syndrome 3; Toriello-Lacassie-Droste syndrome 1 0 0 0 0 0 0 1
Pilocytic astrocytoma 1 0 0 0 0 0 0 1
Primary familial hypertrophic cardiomyopathy 0 0 1 0 0 0 0 1
Primary low grade serous adenocarcinoma of ovary 1 0 0 0 0 0 0 1
See cases 0 0 1 0 0 0 0 1
Teratoma 0 0 1 0 0 0 0 1
Thyroid cancer, nonmedullary, 1 0 1 0 0 0 0 0 1
Toriello-Lacassie-Droste syndrome 0 0 1 0 0 0 0 1
Vascular Tumors Including Pyogenic Granuloma 0 1 0 0 0 0 0 1
Venous malformation 0 1 0 0 0 0 0 1

Submitter and significance breakdown #

Total submitters: 105
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Submitter pathogenic likely pathogenic uncertain significance likely benign benign association not provided total
Labcorp Genetics (formerly Invitae), Labcorp 23 10 61 67 8 0 0 169
GeneDx 24 9 22 24 29 0 0 108
Illumina Laboratory Services, Illumina 0 0 44 34 1 0 0 79
Laboratory of Virology, Oncology, Biosciences and Environment, Faculty of Sciences and Techniques, Mohammedia- University Hassan II of Casablanca 0 0 72 0 0 0 0 72
Ambry Genetics 5 3 10 45 3 0 0 66
Laboratory for Molecular Medicine, Mass General Brigham Personalized Medicine 23 11 9 13 4 0 0 60
CeGaT Center for Human Genetics Tuebingen 11 1 4 12 7 0 0 35
Women's Health and Genetics/Laboratory Corporation of America, LabCorp 3 3 12 6 9 0 0 33
Breakthrough Genomics, Breakthrough Genomics 0 0 0 19 8 0 0 27
OMIM 25 0 0 0 0 0 0 25
PreventionGenetics, part of Exact Sciences 5 2 4 11 3 0 0 25
Department of Pathology and Laboratory Medicine, Sinai Health System 12 1 8 1 0 0 0 22
Fulgent Genetics, Fulgent Genetics 2 0 12 6 0 0 0 20
ClinGen RASopathy Variant Curation Expert Panel 7 1 1 3 2 0 0 14
ARUP Laboratories, Molecular Genetics and Genomics, ARUP Laboratories 3 0 0 4 5 0 0 12
Genome Diagnostics Laboratory, The Hospital for Sick Children 2 0 2 2 4 0 0 10
Eurofins Ntd Llc (ga) 0 1 5 2 2 0 0 10
3billion 8 1 1 0 0 0 0 10
Baylor Genetics 4 2 2 0 1 0 0 9
Blueprint Genetics 4 4 1 0 0 0 0 9
Clinical Genomics Laboratory, Washington University in St. Louis 4 4 1 0 0 0 0 9
Joint Genome Diagnostic Labs from Nijmegen and Maastricht, Radboudumc and MUMC+ 5 0 0 2 1 0 0 8
Greenwood Genetic Center Diagnostic Laboratories, Greenwood Genetic Center 3 1 0 0 3 0 0 7
Clinical Genetics, Academic Medical Center 0 0 0 3 3 0 0 6
Laboratory of Translational Genomics, National Cancer Institute 0 0 0 0 0 0 6 6
Seattle Children's Hospital Molecular Genetics Laboratory, Seattle Children's Hospital 4 2 0 0 0 0 0 6
GeneReviews 0 0 0 0 0 0 5 5
Revvity Omics, Revvity 3 0 1 0 0 0 0 4
Victorian Clinical Genetics Services, Murdoch Childrens Research Institute 3 1 0 0 0 0 0 4
Service de Génétique Moléculaire, Hôpital Robert Debré 0 2 1 1 0 0 0 4
Clinical Genetics DNA and cytogenetics Diagnostics Lab, Erasmus MC, Erasmus Medical Center 1 1 0 2 0 0 0 4
Mayo Clinic Laboratories, Mayo Clinic 2 0 1 0 0 0 0 3
Genomic Medicine Center of Excellence, King Faisal Specialist Hospital and Research Centre 1 2 0 0 0 0 0 3
ITMI 0 0 0 0 0 0 3 3
Diagnostic Laboratory, Department of Genetics, University Medical Center Groningen 0 0 0 1 2 0 0 3
Xiao lab, Department of Pathology, Memorial Sloan Kettering Cancer Center 1 2 0 0 0 0 0 3
AiLife Diagnostics, AiLife Diagnostics 0 1 2 0 0 0 0 3
Key Laboratory of Carcinogenesis and Cancer Invasion, Central South University 0 3 0 0 0 0 0 3
Molecular Diagnostics Lab, Nemours Children's Health, Delaware 1 1 0 0 0 0 0 2
Genome Diagnostics Laboratory, University Medical Center Utrecht 0 0 0 2 0 0 0 2
Equipe Genetique des Anomalies du Developpement, Université de Bourgogne 2 0 0 0 0 0 0 2
Institute of Human Genetics, University of Leipzig Medical Center 2 0 0 0 0 0 0 2
Yale Center for Mendelian Genomics, Yale University 2 1 0 0 0 0 0 2
Juno Genomics, Hangzhou Juno Genomics, Inc 2 0 0 0 0 0 0 2
Center for Genomics, Ann and Robert H. Lurie Children's Hospital of Chicago 1 0 1 0 0 0 0 2
Laboratory of Diagnostic Genome Analysis, Leiden University Medical Center (LUMC) 0 0 0 2 0 0 0 2
Laboratory of Medical Genetics, National & Kapodistrian University of Athens 1 1 0 0 0 0 0 2
St. Jude Molecular Pathology, St. Jude Children's Research Hospital 0 0 2 0 0 0 0 2
Genomic Medicine Lab, University of California San Francisco 1 1 0 0 0 0 0 2
Gharavi Laboratory, Columbia University 1 0 1 0 0 0 0 2
Arin Greene Laboratory, Boston Children's Hospital, Harvard Medical School 2 0 0 0 0 0 0 2
Institute of Medical Sciences, Banaras Hindu University 2 0 0 0 0 0 0 2
Institute of Human Genetics, University Hospital Muenster 1 0 1 0 0 0 0 2
New York Genome Center 1 0 1 0 0 0 0 2
Molecular Genetics, Centre for Human Genetics 2 0 0 0 0 0 0 2
DASA 2 0 0 0 0 0 0 2
Salgia Laboratory, City of Hope 2 0 0 0 0 0 0 2
Center for Human Genetics, Inc, Center for Human Genetics, Inc 0 0 0 1 0 0 0 1
Molecular Genetics Laboratory, BC Children's and BC Women's Hospitals 1 0 0 0 0 0 0 1
Mendelics 0 0 1 0 0 0 0 1
ClinVar Staff, National Center for Biotechnology Information (NCBI) 0 0 0 0 0 0 1 1
Institute of Human Genetics Munich, Klinikum Rechts Der Isar, TU München 0 1 0 0 0 0 0 1
Institute of Human Genetics, FAU Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg 1 0 0 0 0 0 0 1
UCLA Clinical Genomics Center, UCLA 1 0 0 0 0 0 0 1
HudsonAlpha Institute for Biotechnology, HudsonAlpha Institute for Biotechnology 1 0 0 0 0 0 0 1
Institute for Clinical Genetics, University Hospital TU Dresden, University Hospital TU Dresden 0 0 1 0 0 0 0 1
Center for Pediatric Genomic Medicine, Children's Mercy Hospital and Clinics 0 0 0 1 0 0 0 1
Baylor-Hopkins Center for Mendelian Genomics, Johns Hopkins University School of Medicine 0 1 0 0 0 0 0 1
Donald Williams Parsons Laboratory, Baylor College of Medicine 0 1 0 0 0 0 0 1
Centre for Mendelian Genomics, University Medical Centre Ljubljana 0 0 1 0 0 0 0 1
Kamineni Academy of Medical Sciences & Research Centre, Kamineni Hospitals 0 1 0 0 0 0 0 1
Kasturba Medical College, Manipal, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, India 1 0 0 0 0 0 0 1
Daryl Scott Lab, Baylor College of Medicine 1 0 0 0 0 0 0 1
NIHR Bioresource Rare Diseases, University of Cambridge 0 1 0 0 0 0 0 1
Undiagnosed Diseases Network, NIH 0 1 0 0 0 0 0 1
Rady Children's Institute for Genomic Medicine, Rady Children's Hospital San Diego 1 0 0 0 0 0 0 1
GenomeConnect, ClinGen 0 0 0 0 0 0 1 1
Molecular ImmunoRheumatology UMRS_1109, Institut national de la santé et de la recherche médicale 0 0 1 0 0 0 0 1
Institute of Medical Genetics and Applied Genomics, University Hospital Tübingen 1 0 0 0 0 0 0 1
Genome Diagnostics Laboratory, Amsterdam University Medical Center 1 0 0 0 0 0 0 1
Genomics For Life 1 0 0 0 0 0 0 1
Thoracic Oncology Service, Memorial Sloan Kettering Cancer Center 1 0 0 0 0 0 0 1
Laboratory for Clinical Genomics and Advanced Technology, Dartmouth-Hitchcock Medical Center 1 0 0 0 0 0 0 1
Department of Genetics, Rouen University Hospital, Normandy Center for Genomic and Personalized Medicine 0 1 0 0 0 0 0 1
Institute for Genomic Statistics and Bioinformatics, University Hospital Bonn 1 0 0 0 0 0 0 1
GenomeConnect - CFC International 0 0 0 0 0 0 1 1
Unidad de Genómica Garrahan, Hospital de Pediatría Garrahan 0 0 0 0 1 0 0 1
University Health Network, Princess Margaret Cancer Centre 1 0 0 0 0 0 0 1
Clinical Genetics Laboratory, Skane University Hospital Lund 0 1 0 0 0 0 0 1
Molecular Genetics laboratory, Necker Hospital 1 0 0 0 0 0 0 1
Faculté Pluridciplinaire Nador, Université Mohamed Premier 0 0 1 0 0 0 0 1
Prenatal Genetic Diagnosis Laboratory, The Chinese University of Hong Kong 1 0 0 0 0 0 0 1
Diagnostic Genetics, Severance Hospital, Yonsei University College of Medicine 0 1 0 0 0 0 0 1
Molecular Oncology Research Center, Barretos Cancer Hospital 0 1 0 0 0 0 0 1
Beijing Key Laboratry for Genetics of Birth Defects, Beijing Children's Hospital 1 0 0 0 0 0 0 1
Hematopathology, The University of Texas M.D. Anderson Cancer Center 1 0 0 0 0 0 0 1
Institute of Human Genetics, Clinical Exome/Genome Diagnostics Group, University Hospital Bonn 0 0 1 0 0 0 0 1
Laboratorio de Genetica e Diagnostico Molecular, Hospital Israelita Albert Einstein 0 1 0 0 0 0 0 1
Pathology Department, Puerta del Mar University Hospital 0 0 1 0 0 0 0 1
Druker Lab, Oregon Health and Sciences University 1 0 0 0 0 0 0 1
Institute of Immunology and Genetics Kaiserslautern 1 0 0 0 0 0 0 1
Institute Of Reproduction And Development, Obstetrics and Gynecology Hospital, Fudan University 1 0 0 0 0 0 0 1
Martignetti Lab, Icahn School of Medicine at Mount Sinai 0 0 0 0 0 1 0 1
Laboratory of Urology, Hospital Clinic de Barcelona 1 0 0 0 0 0 0 1
Department of Pediatrics, Taizhou Central Hospital, Taizhou University Hospital 1 0 0 0 0 0 0 1

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