ClinVar Miner

Variants in gene KRAS

Minimum submission review status: Collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign drug response not provided total
52 39 84 76 21 1 14 232

Condition and significance breakdown #

Total conditions: 57
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Condition pathogenic likely pathogenic uncertain significance likely benign benign drug response not provided total
Noonan syndrome 8 4 47 35 0 0 0 94
Cardio-facio-cutaneous syndrome 1 1 47 35 0 0 0 84
not provided 22 10 15 13 8 0 0 64
not specified 2 0 16 28 14 0 3 53
Rasopathy 9 5 7 7 4 0 1 32
Neoplasm of the large intestine 22 4 0 0 0 0 0 26
Non-small cell lung cancer 17 5 0 0 0 0 1 22
Neoplasm of the thyroid gland 13 2 0 0 0 0 0 15
Noonan syndrome 3 7 2 0 1 0 0 0 10
Cardiofaciocutaneous syndrome 2 7 0 0 0 0 0 0 7
Noonan syndrome; Cardio-facio-cutaneous syndrome 4 3 0 0 0 0 0 7
Acute myeloid leukemia 1 5 0 0 0 0 0 6
Ovarian Neoplasms 6 0 0 0 0 0 0 6
Juvenile myelomonocytic leukemia 4 0 0 0 0 0 0 4
OCULOECTODERMAL SYNDROME, SOMATIC 4 0 0 0 0 0 0 4
Lung adenocarcinoma 0 2 0 0 0 0 1 3
RAS-associated autoimmune leukoproliferative disorder 3 0 0 0 0 0 0 3
Adenocarcinoma of stomach 0 2 0 0 0 0 0 2
Angiosarcoma 0 2 0 0 0 0 0 2
Carcinoma of pancreas 2 0 0 0 0 0 1 2
Cerebral arteriovenous malformation 2 0 0 0 0 0 0 2
Endometrial carcinoma 0 0 0 0 0 0 2 2
Hepatocellular carcinoma 0 2 0 0 0 0 0 2
Lung cancer 1 1 0 0 0 0 1 2
Malignant melanoma of skin 0 2 0 0 0 0 0 2
Multiple myeloma 0 2 0 0 0 0 0 2
Neoplasm of ovary 1 0 0 0 0 0 1 2
Neoplasm of stomach 2 0 0 0 0 0 0 2
Nevus sebaceous 2 0 0 0 0 0 0 2
Noonan syndrome 3; RAS-associated autoimmune leukoproliferative disorder; Acute myeloid leukemia; Cardiofaciocutaneous syndrome 2 1 1 0 0 0 0 0 2
Sarcoma 0 0 0 0 0 0 2 2
Squamous cell lung carcinoma 1 1 0 0 0 0 0 2
Adenoid cystic carcinoma 1 0 0 0 0 0 0 1
Bladder cancer, somatic 1 0 0 0 0 0 0 1
Bladder cancer, transitional cell, somatic 1 0 0 0 0 0 0 1
Breast adenocarcinoma 1 0 0 0 0 0 0 1
Carcinoma of esophagus 0 1 0 0 0 0 0 1
Chronic lymphocytic leukemia 0 1 0 0 0 0 0 1
Craniopharyngioma 0 0 1 0 0 0 0 1
Epidermal nevus 1 0 0 0 0 0 0 1
Epidermal nevus syndrome 1 0 0 0 0 0 0 1
Familial cancer of breast 0 0 0 0 0 0 1 1
Familial cancer of breast; Hereditary diffuse gastric cancer; Lung cancer; Noonan syndrome 3; Epidermal nevus syndrome; Cerebral arteriovenous malformation; Bladder cancer, somatic; Carcinoma of pancreas; RAS-associated autoimmune leukoproliferative disorder; Acute myeloid leukemia; Cardiofaciocutaneous syndrome 2 1 0 0 0 0 0 0 1
Gastrointestinal stroma tumor 0 1 0 0 0 0 0 1
Inborn genetic diseases 0 0 1 0 0 0 0 1
Malignant neoplasm of body of uterus 0 1 0 0 0 0 0 1
Medullary thyroid carcinoma 0 1 0 0 0 0 0 1
Noonan syndrome 1 0 0 0 0 0 0 1 1
Noonan syndrome 3; Cardiofaciocutaneous syndrome 2 1 0 0 0 0 0 0 1
Noonan syndrome 3; Epidermal nevus syndrome; RAS-associated autoimmune leukoproliferative disorder; Acute myeloid leukemia; Cardiofaciocutaneous syndrome 2 0 0 1 0 0 0 0 1
Pancreatic adenocarcinoma 0 1 0 0 0 0 0 1
Pilocytic astrocytoma 1 0 0 0 0 0 0 1
Primary familial hypertrophic cardiomyopathy 0 0 1 0 0 0 0 1
Transitional cell carcinoma of the bladder 0 1 0 0 0 0 0 1
Vascular Tumors Including Pyogenic Granuloma 0 1 0 0 0 0 0 1
cetuximab response - Dosage 0 0 0 0 0 1 0 1
panitumumab response - Dosage 0 0 0 0 0 1 0 1

Submitter and significance breakdown #

Total submitters: 35
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Submitter pathogenic likely pathogenic uncertain significance likely benign benign drug response not provided total
Illumina Clinical Services Laboratory,Illumina 0 0 47 35 0 0 0 82
Laboratory for Molecular Medicine,Partners HealthCare Personalized Medicine 23 11 11 21 5 0 0 71
GeneDx 21 6 7 14 14 0 0 62
Database of Curated Mutations (DoCM) 23 15 0 0 0 0 4 28
OMIM 25 0 0 0 0 0 0 25
Invitae 8 4 6 6 1 0 0 25
Integrated Genetics/Laboratory Corporation of America 1 1 7 2 4 0 0 15
ClinGen RASopathy Variant Curation Expert Panel 7 0 0 3 2 0 0 12
EGL Genetic Diagnostics,Eurofins Clinical Diagnostics 0 1 5 2 2 0 0 10
Blueprint Genetics 4 4 1 0 0 0 0 9
PreventionGenetics 0 0 0 4 3 0 0 7
Baylor Genetics 3 1 1 0 1 0 0 6
Laboratory of Translational Genomics, National Cancer Institute 0 0 0 0 0 0 6 6
Greenwood Genetic Center Diagnostic Laboratories,Greenwood Genetic Center 2 0 0 0 3 0 0 5
ARUP Laboratories, Molecular Genetics and Genomics, ARUP Laboratories 2 0 0 0 1 0 0 3
ITMI 0 0 0 0 0 0 3 3
Molecular Diagnostics Lab,Nemours Alfred I. duPont Hospital for Children 1 1 0 0 0 0 0 2
Genome Sciences Centre,British Columbia Cancer Agency 1 1 0 0 0 0 0 2
Yale Center for Mendelian Genomics,Yale University 2 1 0 0 0 0 0 2
Center for Genomics, Ann and Robert H. Lurie Children's Hospital of Chicago 1 0 1 0 0 0 0 2
Gharavi Laboratory,Columbia University 1 0 1 0 0 0 0 2
Center for Human Genetics, Inc 0 0 0 1 0 0 0 1
Ambry Genetics 0 0 1 0 0 0 0 1
Fulgent Genetics,Fulgent Genetics 1 0 0 0 0 0 0 1
ClinVar Staff, National Center for Biotechnology Information (NCBI) 0 0 0 0 0 0 1 1
PharmGKB 0 0 0 0 0 1 0 1
Institute of Human Genetics,Friedrich-Alexander-Universität Erlangen-Nürnberg 1 0 0 0 0 0 0 1
UCLA Clinical Genomics Center, UCLA 1 0 0 0 0 0 0 1
Center for Pediatric Genomic Medicine,Children's Mercy Hospital and Clinics 0 0 0 1 0 0 0 1
Donald Williams Parsons Laboratory,Baylor College of Medicine 0 1 0 0 0 0 0 1
GenomeConnect, ClinGen 0 0 0 0 0 0 1 1
Laboratory of Medical Genetics,National & Kapodistrian University of Athens 0 1 0 0 0 0 0 1
Clinical Genomics Lab,St. Jude Children's Research Hospital 0 0 1 0 0 0 0 1
Thoracic Oncology Service,Memorial Sloan Kettering Cancer Center 1 0 0 0 0 0 0 1
Laboratory for Clinical Genomics and Advanced Technology,Dartmouth-Hitchcock Medical Center 1 0 0 0 0 0 0 1

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