ClinVar Miner

Variants in gene LAMA4

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Gene type:
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If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign not provided total
2 1 244 260 156 3 583

Condition and significance breakdown #

Total conditions: 22
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Condition pathogenic likely pathogenic uncertain significance likely benign benign not provided total
not provided 0 1 88 124 118 0 319
not specified 0 0 56 119 66 3 219
Dilated cardiomyopathy 1JJ 2 0 110 41 25 0 169
Cardiovascular phenotype 0 0 25 30 7 0 62
Cardiomyopathy 0 0 22 16 11 0 47
Primary familial hypertrophic cardiomyopathy 0 0 7 0 0 0 7
Primary dilated cardiomyopathy 0 0 6 0 0 0 6
Arrhythmogenic right ventricular cardiomyopathy 0 0 3 0 0 0 3
Wolff-Parkinson-White pattern 0 0 2 0 0 0 2
Brugada syndrome 0 0 1 0 0 0 1
Brugada syndrome 9 0 0 1 0 0 0 1
Cardiomyopathy; Hypertrophic cardiomyopathy 0 0 0 0 1 0 1
Catecholaminergic polymorphic ventricular tachycardia type 1 0 0 1 0 0 0 1
Dilated cardiomyopathy 0 0 0 0 1 0 1
Dilated cardiomyopathy 1S 0 0 0 1 0 0 1
Familial atrial fibrillation 0 0 1 0 0 0 1
Familial hypertrophic cardiomyopathy 1 0 0 1 0 0 0 1
Hypertrophic cardiomyopathy; Ventricular tachycardia 0 0 0 1 0 0 1
Left ventricular noncompaction cardiomyopathy 0 0 1 0 0 0 1
Long QT syndrome; Dilated cardiomyopathy 0 0 0 1 0 0 1
Premature ventricular contraction 0 0 0 1 0 0 1
Spinocerebellar ataxia 19 0 0 1 0 0 0 1

Submitter and significance breakdown #

Total submitters: 28
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Submitter pathogenic likely pathogenic uncertain significance likely benign benign not provided total
GeneDx 0 1 58 116 136 0 311
Invitae 0 0 102 91 46 0 239
Laboratory for Molecular Medicine, Partners HealthCare Personalized Medicine 0 0 50 59 38 3 150
Ambry Genetics 0 0 25 30 7 0 62
CHEO Genetics Diagnostic Laboratory,Children's Hospital of Eastern Ontario 0 0 21 13 11 0 45
Biesecker Lab/Clinical Genomics Section,National Institutes of Health 0 0 22 6 10 0 38
Diagnostic Laboratory, Department of Genetics,University Medical Center Groningen 0 0 5 24 9 0 38
ARUP Laboratories, Molecular Genetics and Genomics, ARUP Laboratories 0 0 5 5 10 0 20
DNA and Cytogenetics Diagnostics Unit,Erasmus Medical Center 0 0 1 6 11 0 18
PreventionGenetics,PreventionGenetics 0 0 0 0 14 0 14
Blueprint Genetics 0 0 12 0 0 0 12
Stanford Center for Inherited Cardiovascular Disease, Stanford University 0 0 11 0 0 0 11
Center for Advanced Laboratory Medicine, UC San Diego Health,University of California San Diego 0 0 3 6 2 0 11
Genome Diagnostics Laboratory,University Medical Center Utrecht 0 0 2 1 6 0 9
EGL Genetic Diagnostics,Eurofins Clinical Diagnostics 0 0 4 1 1 0 6
CeGaT Praxis fuer Humangenetik Tuebingen 0 0 3 3 0 0 6
Fulgent Genetics,Fulgent Genetics 0 0 4 0 0 0 4
Clinical Molecular Genetics Laboratory,Johns Hopkins All Children's Hospital 0 0 3 0 0 0 3
Klaassen Lab,Charite University Medicine Berlin 0 0 3 0 0 0 3
OMIM 2 0 0 0 0 0 2
Lupski Lab, Baylor-Hopkins CMG, Baylor College of Medicine 0 0 2 0 0 0 2
Laboratory of Genetics and Genomics,Cincinnati Children's Hospital Medical Center 0 0 0 0 2 0 2
Mendelics 0 0 0 0 1 0 1
Genomic Research Center, Shahid Beheshti University of Medical Sciences 0 0 1 0 0 0 1
Agnes Ginges Centre for Molecular Cardiology,Centenary Institute 0 0 1 0 0 0 1
Molecular Diagnostic Laboratory for Inherited Cardiovascular Disease,Montreal Heart Institute 0 0 1 0 0 0 1
Erich and Hanna Klessmann Institute for Cardiovascular Research and Development,Heart and Diabetes Center North Rhine-Westphalia 0 0 0 1 0 0 1
Phosphorus, Inc. 0 0 1 0 0 0 1

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