ClinVar Miner

Variants in gene LAMA4

Minimum submission review status: Collection method:
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Gene type:
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If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign not provided total
2 1 398 286 159 4 755

Condition and significance breakdown #

Total conditions: 22
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Condition pathogenic likely pathogenic uncertain significance likely benign benign not provided total
Dilated cardiomyopathy 1JJ 2 0 278 120 53 0 437
not provided 0 1 90 91 81 1 260
not specified 0 0 57 120 66 3 221
Cardiomyopathy 0 0 28 20 22 0 68
Cardiovascular phenotype 0 0 25 30 7 0 62
Primary dilated cardiomyopathy 0 0 6 1 1 0 8
Primary familial hypertrophic cardiomyopathy 0 0 7 0 0 0 7
Arrhythmogenic right ventricular cardiomyopathy 0 0 3 0 0 0 3
Wolff-Parkinson-White pattern 0 0 2 0 0 0 2
Brugada syndrome 0 0 1 0 0 0 1
Brugada syndrome 9 0 0 1 0 0 0 1
Cardiomyopathy, left ventricular noncompaction 0 0 1 0 0 0 1
Cardiomyopathy; Hypertrophic cardiomyopathy 0 0 0 0 1 0 1
Catecholaminergic polymorphic ventricular tachycardia type 1 0 0 1 0 0 0 1
Dilated cardiomyopathy 1S 0 0 0 1 0 0 1
Familial atrial fibrillation 0 0 1 0 0 0 1
Familial hypertrophic cardiomyopathy 1 0 0 1 0 0 0 1
Hypertrophic cardiomyopathy; Ventricular tachycardia 0 0 0 1 0 0 1
Inborn genetic diseases 0 0 1 0 0 0 1
Premature ventricular contraction 0 0 0 1 0 0 1
Primary dilated cardiomyopathy; Long QT syndrome 0 0 0 1 0 0 1
Spinocerebellar ataxia type 19/22 0 0 1 0 0 0 1

Submitter and significance breakdown #

Total submitters: 35
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Submitter pathogenic likely pathogenic uncertain significance likely benign benign not provided total
Invitae 0 0 267 122 46 0 435
GeneDx 0 1 58 116 136 0 311
Laboratory for Molecular Medicine,Partners HealthCare Personalized Medicine 0 0 51 60 38 3 152
CHEO Genetics Diagnostic Laboratory,Children's Hospital of Eastern Ontario 0 0 27 17 22 0 66
Ambry Genetics 0 0 26 30 7 0 63
Biesecker Lab/Clinical Genomics Section,National Institutes of Health 0 0 22 6 10 0 38
Diagnostic Laboratory, Department of Genetics, University Medical Center Groningen 0 0 5 24 9 0 38
ARUP Laboratories, Molecular Genetics and Genomics,ARUP Laboratories 0 0 7 8 17 0 32
DNA and Cytogenetics Diagnostics Unit,Erasmus Medical Center 0 0 1 6 11 0 18
PreventionGenetics, PreventionGenetics 0 0 0 0 14 0 14
Blueprint Genetics 0 0 12 0 0 0 12
Stanford Center for Inherited Cardiovascular Disease, Stanford University 0 0 11 0 0 0 11
Center for Advanced Laboratory Medicine, UC San Diego Health,University of California San Diego 0 0 3 6 2 0 11
Genome Diagnostics Laboratory,University Medical Center Utrecht 0 0 2 1 6 0 9
EGL Genetic Diagnostics, Eurofins Clinical Diagnostics 0 0 4 1 1 0 6
CeGaT Praxis fuer Humangenetik Tuebingen 0 0 3 3 0 0 6
Fulgent Genetics,Fulgent Genetics 0 0 4 0 0 0 4
Clinical Molecular Genetics Laboratory,Johns Hopkins All Children's Hospital 0 0 3 0 0 0 3
Centre for Mendelian Genomics,University Medical Centre Ljubljana 0 0 3 0 0 0 3
Klaassen Lab,Charite University Medicine Berlin 0 0 3 0 0 0 3
OMIM 2 0 0 0 0 0 2
Baylor Genetics 0 0 2 0 0 0 2
Cincinnati Children's Hospital Medical Center Laboratory of Genetics and Genomics,Cincinnati Children's Hospital Medical Center 0 0 0 0 2 0 2
Lupski Lab, Baylor-Hopkins CMG, Baylor College of Medicine 0 0 2 0 0 0 2
Department of Pathology and Laboratory Medicine,Sinai Health System 0 0 2 0 0 0 2
Mendelics 0 0 0 0 1 0 1
Genomic Research Center, Shahid Beheshti University of Medical Sciences 0 0 1 0 0 0 1
Agnes Ginges Centre for Molecular Cardiology,Centenary Institute 0 0 1 0 0 0 1
Molecular Diagnostic Laboratory for Inherited Cardiovascular Disease,Montreal Heart Institute 0 0 1 0 0 0 1
Erich and Hanna Klessmann Institute for Cardiovascular Research and Development,Heart and Diabetes Center North Rhine-Westphalia 0 0 0 1 0 0 1
Institute of Human Genetics, University of Leipzig Medical Center 0 0 0 0 1 0 1
Phosphorus, Inc. 0 0 1 0 0 0 1
GenomeConnect, ClinGen 0 0 0 0 0 1 1
Genetics and Genomics Program,Sidra Medicine 0 0 0 1 0 0 1
New York Genome Center 0 0 1 0 0 0 1

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