ClinVar Miner

Variants in gene LAMA4

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Minimum submission review status: Collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign not provided total
1 1 1150 745 209 4 1921

Condition and significance breakdown #

Total conditions: 24
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Condition pathogenic likely pathogenic uncertain significance likely benign benign not provided total
Dilated cardiomyopathy 1JJ 1 0 737 434 88 0 1228
Cardiovascular phenotype 0 0 611 350 10 0 971
not provided 0 1 258 165 105 1 520
not specified 0 0 61 127 88 3 235
Cardiomyopathy 0 0 28 20 22 0 68
LAMA4-related disorder 0 0 19 31 4 0 54
Primary dilated cardiomyopathy 0 0 7 1 0 0 8
Primary familial hypertrophic cardiomyopathy 0 0 7 0 0 0 7
Arrhythmogenic right ventricular cardiomyopathy 0 0 3 0 0 0 3
Wolff-Parkinson-White pattern 0 0 2 0 0 0 2
Brugada syndrome 0 0 1 0 0 0 1
Brugada syndrome 9 0 0 1 0 0 0 1
Cardiomyopathy; Hypertrophic cardiomyopathy 0 0 0 0 1 0 1
Catecholaminergic polymorphic ventricular tachycardia 1 0 0 1 0 0 0 1
Dilated cardiomyopathy 1S 0 0 0 1 0 0 1
Dilated cardiomyopathy 3B 0 0 1 0 0 0 1
Familial atrial fibrillation 0 0 1 0 0 0 1
Hypertrophic cardiomyopathy 1 0 0 1 0 0 0 1
Hypertrophic cardiomyopathy; Ventricular tachycardia 0 0 0 1 0 0 1
Inborn genetic diseases 0 0 1 0 0 0 1
Left ventricular noncompaction cardiomyopathy 0 0 1 0 0 0 1
Premature ventricular contraction 0 0 0 1 0 0 1
Primary dilated cardiomyopathy; Long QT syndrome 0 0 0 1 0 0 1
Spinocerebellar ataxia type 19/22 0 0 1 0 0 0 1

Submitter and significance breakdown #

Total submitters: 52
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Submitter pathogenic likely pathogenic uncertain significance likely benign benign not provided total
Labcorp Genetics (formerly Invitae), Labcorp 0 0 708 416 83 0 1207
Ambry Genetics 0 0 612 350 10 0 972
GeneDx 0 1 194 155 159 0 509
Laboratory for Molecular Medicine, Mass General Brigham Personalized Medicine 0 0 50 59 38 3 150
Fulgent Genetics, Fulgent Genetics 0 0 106 19 2 0 127
Women's Health and Genetics/Laboratory Corporation of America, LabCorp 0 0 7 31 42 0 80
Clinical Genetics, Academic Medical Center 0 0 10 7 62 0 79
PreventionGenetics, part of Exact Sciences 0 0 19 31 18 0 68
CHEO Genetics Diagnostic Laboratory, Children's Hospital of Eastern Ontario 0 0 27 17 22 0 66
Clinical Genetics DNA and cytogenetics Diagnostics Lab, Erasmus MC, Erasmus Medical Center 0 0 8 36 22 0 66
Diagnostic Laboratory, Department of Genetics, University Medical Center Groningen 0 0 8 30 12 0 50
Genome Diagnostics Laboratory, University Medical Center Utrecht 0 0 8 24 16 0 48
Joint Genome Diagnostic Labs from Nijmegen and Maastricht, Radboudumc and MUMC+ 0 0 4 22 19 0 45
ARUP Laboratories, Molecular Genetics and Genomics, ARUP Laboratories 0 0 8 12 21 0 41
Biesecker Lab/Clinical Genomics Section, National Institutes of Health 0 0 21 6 10 0 37
Breakthrough Genomics, Breakthrough Genomics 0 0 3 21 0 0 24
CeGaT Center for Human Genetics Tuebingen 0 0 6 8 5 0 19
AiLife Diagnostics, AiLife Diagnostics 0 0 15 0 0 0 15
Blueprint Genetics 0 0 12 0 0 0 12
Genome-Nilou Lab 0 0 0 0 12 0 12
Stanford Center for Inherited Cardiovascular Disease, Stanford University 0 0 11 0 0 0 11
Mayo Clinic Laboratories, Mayo Clinic 0 0 10 0 0 0 10
Center for Advanced Laboratory Medicine, UC San Diego Health, University of California San Diego 0 0 2 6 1 0 9
Revvity Omics, Revvity 0 0 6 0 0 0 6
Department of Pathology and Laboratory Medicine, Sinai Health System 0 0 6 0 0 0 6
Eurofins Ntd Llc (ga) 0 0 3 1 1 0 5
Clinical Genomics Laboratory, Stanford Medicine 0 0 5 0 0 0 5
Neuberg Centre For Genomic Medicine, NCGM 0 0 5 0 0 0 5
Clinical Molecular Genetics Laboratory, Johns Hopkins All Children's Hospital 0 0 3 0 0 0 3
Victorian Clinical Genetics Services, Murdoch Childrens Research Institute 0 0 3 0 0 0 3
Centre for Mendelian Genomics, University Medical Centre Ljubljana 0 0 3 0 0 0 3
Institute of Human Genetics, University of Leipzig Medical Center 0 0 2 0 1 0 3
Center for Genomics, Ann and Robert H. Lurie Children's Hospital of Chicago 0 0 3 0 0 0 3
Klaassen Lab, Charite University Medicine Berlin 0 0 3 0 0 0 3
Baylor Genetics 0 0 2 0 0 0 2
Lupski Lab, Baylor-Hopkins CMG, Baylor College of Medicine 0 0 2 0 0 0 2
Clinical Genetics Laboratory, Skane University Hospital Lund 0 0 2 0 0 0 2
OMIM 1 0 0 0 0 0 1
Mendelics 0 0 0 0 1 0 1
Genomic Medicine Center of Excellence, King Faisal Specialist Hospital and Research Centre 0 0 1 0 0 0 1
Genomic Research Center, Shahid Beheshti University of Medical Sciences 0 0 1 0 0 0 1
Agnes Ginges Centre for Molecular Cardiology, Centenary Institute 0 0 1 0 0 0 1
Petrovsky National Research Centre of Surgery, The Federal Agency for Scientific Organizations 0 0 1 0 0 0 1
Molecular Diagnostic Laboratory for Inherited Cardiovascular Disease, Montreal Heart Institute 0 0 1 0 0 0 1
Institut für Laboratoriums- und Transfusionsmedizin, Herz- und Diabeteszentrum Nordrhein-Westfalen 0 0 0 1 0 0 1
Institute of Human Genetics, University of Wuerzburg 0 0 1 0 0 0 1
Daryl Scott Lab, Baylor College of Medicine 0 0 1 0 0 0 1
Phosphorus, Inc. 0 0 1 0 0 0 1
GenomeConnect, ClinGen 0 0 0 0 0 1 1
Laboratory of Diagnostic Genome Analysis, Leiden University Medical Center (LUMC) 0 0 0 1 0 0 1
Genetics and Genomics Program, Sidra Medicine 0 0 0 1 0 0 1
New York Genome Center 0 0 1 0 0 0 1

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