Variants in gene combination LOC106736614, RET

Minimum submission review status:		Collection method:
Minimum conflict level: Report conflict between different conditions
Gene type: Distinguish antisense genes from sense genes
Show significances as they were submitted (without aggregation into standard terms)
		ClinVar version:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic	likely pathogenic	uncertain significance	likely benign	benign	total
0	0	40	25	6	63

Condition and significance breakdown #

Total conditions: 13

Download table as spreadsheet

Condition	uncertain significance	likely benign	benign	total
Hereditary cancer-predisposing syndrome	19	15	1	34
Multiple endocrine neoplasia, type 2	25	7	0	32
not provided	4	5	4	13
Multiple endocrine neoplasia	5	1	2	8
Pheochromocytoma	5	1	2	8
Renal hypodysplasia/aplasia 1	5	2	1	8
Hirschsprung disease, susceptibility to, 1	5	0	1	6
Hirschsprung Disease, Dominant	1	1	1	3
Hirschsprung disease, susceptibility to, 1; Multiple endocrine neoplasia, type 2b; Pheochromocytoma; Familial medullary thyroid carcinoma; Multiple endocrine neoplasia, type 2a	2	1	0	3
RET-related condition	1	2	0	3
not specified	2	1	0	3
Malignant tumor of breast	1	0	0	1
Multiple endocrine neoplasia, type 2a	1	0	0	1

Submitter and significance breakdown #

Total submitters: 17

Download table as spreadsheet

Submitter	uncertain significance	likely benign	benign	total
Ambry Genetics	18	14	1	33
Invitae	25	7	0	32
GeneDx	3	4	4	11
Illumina Laboratory Services, Illumina	5	2	2	8
PreventionGenetics, part of Exact Sciences	1	2	0	3
Fulgent Genetics, Fulgent Genetics	2	1	0	3
Sema4, Sema4	1	1	0	2
Baylor Genetics	1	0	0	1
Genetic Services Laboratory, University of Chicago	0	1	0	1
Laboratory for Molecular Medicine, Mass General Brigham Personalized Medicine	1	0	0	1
Women's Health and Genetics/Laboratory Corporation of America, LabCorp	1	0	0	1
GeneKor MSA	1	0	0	1
Institute for Clinical Genetics, University Hospital TU Dresden, University Hospital TU Dresden	1	0	0	1
Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital	1	0	0	1
Color Diagnostics, LLC DBA Color Health	0	1	0	1
CeGaT Center for Human Genetics Tuebingen	0	1	0	1
Center of Medical Genetics and Primary Health Care	1	0	0	1

The information on this website is not intended for direct diagnostic use or medical decision-making without review by a genetics professional. Individuals should not change their health behavior solely on the basis of information contained on this website. Neither the University of Utah nor the National Institutes of Health independently verfies the submitted information. If you have questions about the information contained on this website, please see a health care professional.