Variants in gene LORICRIN

Minimum submission review status:		Collection method:
Minimum conflict level: Report conflict between different conditions
Gene type: Distinguish antisense genes from sense genes
Show significances as they were submitted (without aggregation into standard terms)
		ClinVar version:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic	likely pathogenic	uncertain significance	likely benign	benign	total
4	3	61	18	16	97

Condition and significance breakdown #

Total conditions: 3

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Condition	pathogenic	likely pathogenic	uncertain significance	likely benign	benign	total
not provided	2	1	20	16	16	54
not specified	0	0	41	2	0	43
Loricrin keratoderma	3	2	3	1	0	9

Submitter and significance breakdown #

Total submitters: 13

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Submitter	pathogenic	likely pathogenic	uncertain significance	likely benign	benign	total
Labcorp Genetics (formerly Invitae), Labcorp	1	0	20	13	14	48
Ambry Genetics	0	0	41	2	0	43
GeneDx	2	1	0	0	6	9
Breakthrough Genomics, Breakthrough Genomics	0	0	0	0	7	7
CeGaT Center for Human Genetics Tuebingen	1	0	0	2	3	6
OMIM	2	0	0	0	0	2
Revvity Omics, Revvity	1	1	0	0	0	2
Department of Pathology and Laboratory Medicine, Sinai Health System	0	0	1	1	0	2
Victorian Clinical Genetics Services, Murdoch Childrens Research Institute	1	0	0	0	0	1
Genomic Research Center, Shahid Beheshti University of Medical Sciences	0	0	1	0	0	1
Al Jalila Children’s Genomics Center, Al Jalila Childrens Speciality Hospital	0	1	0	0	0	1
Molecular Genetics, Royal Melbourne Hospital	0	0	0	1	0	1
Laboratorio de Genetica e Diagnostico Molecular, Hospital Israelita Albert Einstein	0	0	1	0	0	1

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