ClinVar Miner

Variants in gene MET

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Minimum submission review status: Collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign risk factor other not provided total
16 18 2248 1379 144 3 1 38 3537

Condition and significance breakdown #

Total conditions: 30
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Condition pathogenic likely pathogenic uncertain significance likely benign benign risk factor other not provided total
Renal cell carcinoma 3 1 1660 1025 58 0 0 2 2746
Hereditary cancer-predisposing syndrome 4 2 1058 694 32 0 0 0 1759
not provided 3 0 303 80 41 0 0 5 416
Papillary renal cell carcinoma type 1 8 1 136 39 64 0 0 1 238
not specified 0 0 66 89 39 0 0 30 199
Autosomal recessive nonsyndromic hearing loss 97 1 0 128 0 5 0 0 0 134
MET-related condition 1 0 23 42 1 0 0 0 67
Osteofibrous dysplasia; Papillary renal cell carcinoma type 1; Hepatocellular carcinoma; Autosomal recessive nonsyndromic hearing loss 97 0 0 23 1 0 0 0 0 24
Hereditary cancer 0 0 2 10 0 0 0 0 12
Carcinoma 0 9 0 0 0 0 0 0 9
Neoplasm 0 8 0 0 0 0 0 0 8
Osteofibrous dysplasia 0 0 6 0 0 2 0 0 8
Ovarian cancer 0 2 0 0 5 0 0 0 7
Renal carcinoma 0 5 0 0 0 0 0 0 5
Intellectual disability 0 0 1 3 0 0 0 0 4
Arthrogryposis, distal, IIa 11 1 0 2 0 0 0 0 0 3
Inborn genetic diseases 0 0 3 0 0 0 0 0 3
Pediatric hepatocellular carcinoma 3 0 0 0 0 0 0 0 3
Arthrogryposis, distal, type 1A 0 0 0 0 0 1 0 0 1
Breast carcinoma 0 0 1 0 0 0 0 0 1
Classic Hodgkin lymphoma 0 0 1 0 0 0 0 0 1
Colorectal cancer 1 0 0 0 0 0 0 0 1
Congenital diaphragmatic hernia 0 0 1 0 0 0 0 0 1
Hepatoblastoma 0 0 1 0 0 0 0 0 1
Hereditary papillary renal cell carcinoma 0 0 1 0 0 0 0 0 1
Lung carcinoma 1 0 0 0 0 0 0 0 1
Lymphedema 0 0 0 1 0 0 0 0 1
Neuroblastoma 0 0 0 0 0 0 1 0 1
Nonsyndromic Hearing Loss and Deafness, Autosomal Recessive 1 0 0 0 0 0 0 0 1
Squamous cell lung carcinoma 0 0 1 0 0 0 0 0 1

Submitter and significance breakdown #

Total submitters: 60
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Submitter pathogenic likely pathogenic uncertain significance likely benign benign risk factor other not provided total
Invitae 3 1 1667 1030 57 0 0 0 2758
Ambry Genetics 4 2 1030 689 25 0 0 0 1750
GeneDx 1 0 254 83 37 0 0 0 375
Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital 1 0 54 70 19 0 0 0 144
Baylor Genetics 0 0 134 0 0 0 0 0 134
Illumina Laboratory Services, Illumina 0 0 60 15 57 0 0 0 132
Sema4, Sema4 0 0 44 39 10 0 0 0 93
Mendelics 1 0 49 27 8 0 0 0 85
PreventionGenetics, part of Exact Sciences 1 0 23 44 16 0 0 0 84
Eurofins Ntd Llc (ga) 1 0 17 1 15 0 0 0 34
ITMI 0 0 0 0 0 0 0 30 30
Biesecker Lab/Clinical Genomics Section, National Institutes of Health 0 0 19 0 5 0 0 0 24
Women's Health and Genetics/Laboratory Corporation of America, LabCorp 0 0 6 1 17 0 0 0 24
Fulgent Genetics, Fulgent Genetics 0 0 23 1 0 0 0 0 24
CeGaT Center for Human Genetics Tuebingen 0 0 6 11 4 0 0 0 21
St. Jude Molecular Pathology, St. Jude Children's Research Hospital 0 0 19 0 1 0 0 0 20
Clinical Genetics, Academic Medical Center 0 0 0 5 14 0 0 0 19
KCCC/NGS Laboratory, Kuwait Cancer Control Center 0 0 0 5 14 0 0 0 19
ARUP Laboratories, Molecular Genetics and Genomics, ARUP Laboratories 0 0 6 1 10 0 0 0 17
Institute for Clinical Genetics, University Hospital TU Dresden, University Hospital TU Dresden 0 0 17 0 0 0 0 0 17
Database of Curated Mutations (DoCM) 0 15 0 0 0 0 0 0 15
OMIM 12 0 0 0 0 2 0 0 14
Joint Genome Diagnostic Labs from Nijmegen and Maastricht, Radboudumc and MUMC+ 0 0 0 1 12 0 0 0 13
Genetic Services Laboratory, University of Chicago 0 0 2 5 2 0 0 0 9
Revvity Omics, Revvity 1 0 8 0 0 0 0 0 9
Genome Diagnostics Laboratory, University Medical Center Utrecht 1 0 0 1 7 0 0 0 9
Quest Diagnostics Nichols Institute San Juan Capistrano 0 0 6 0 3 0 0 0 9
Genome Diagnostics Laboratory, Amsterdam University Medical Center 1 0 0 4 3 0 0 0 8
Clinical Genetics DNA and cytogenetics Diagnostics Lab, Erasmus MC, Erasmus Medical Center 0 0 1 6 1 0 0 0 8
Diagnostic Laboratory, Department of Genetics, University Medical Center Groningen 0 0 1 2 4 0 0 0 7
Laboratory of Molecular Epidemiology of Birth Defects, West China Second University Hospital, Sichuan University 0 2 0 0 5 0 0 0 7
Athena Diagnostics Inc 0 0 1 0 5 0 0 0 6
Vantari Genetics 0 0 3 1 1 0 0 0 5
MutSpliceDB: a database of splice sites variants effects on splicing, NIH 0 0 0 0 0 0 0 5 5
Genome-Nilou Lab 0 0 0 0 5 0 0 0 5
Centre de Biologie Pathologie Génétique, Centre Hospitalier Universitaire de Lille 0 0 1 3 0 0 0 0 4
GenomeConnect - Invitae Patient Insights Network 0 0 0 0 0 0 0 3 3
Institute of Human Genetics, University of Leipzig Medical Center 0 0 1 1 0 0 0 0 2
Neuberg Supratech Reference Laboratories Pvt Ltd, Neuberg Centre for Genomic Medicine 0 0 2 0 0 0 0 0 2
Laboratorio de Genetica e Diagnostico Molecular, Hospital Israelita Albert Einstein 0 0 2 0 0 0 0 0 2
Institute of Human Genetics, University of Goettingen 0 0 1 0 0 0 0 0 1
Laboratory for Molecular Medicine, Mass General Brigham Personalized Medicine 0 0 1 0 0 0 0 0 1
Institute of Human Genetics, Cologne University 0 0 1 0 0 0 0 0 1
MGZ Medical Genetics Center 0 0 1 0 0 0 0 0 1
CSER _CC_NCGL, University of Washington 0 0 0 1 0 0 0 0 1
School of Biological Sciences, University of the Punjab 1 0 0 0 0 0 0 0 1
Lupski Lab, Baylor-Hopkins CMG, Baylor College of Medicine 0 0 1 0 0 0 0 0 1
Center for Pediatric Genomic Medicine, Children's Mercy Hospital and Clinics 0 0 0 1 0 0 0 0 1
Donald Williams Parsons Laboratory, Baylor College of Medicine 0 0 0 0 0 0 1 0 1
Genetics and Molecular Pathology, SA Pathology 0 0 0 0 1 0 0 0 1
Department of Pathology and Laboratory Medicine, Sinai Health System 0 0 1 0 0 0 0 0 1
The Spine Surgery of The First Affiliated Hospital, Sun Yat-sen University 0 0 0 0 0 1 0 0 1
Laboratory of Diagnostic Genome Analysis, Leiden University Medical Center (LUMC) 0 0 0 1 0 0 0 0 1
Clinical Genetics Laboratory, Department of Pathology, Netherlands Cancer Institute 0 0 0 0 1 0 0 0 1
Myriad Genetics, Inc. 0 1 0 0 0 0 0 0 1
Faculté Pluridciplinaire Nador, Université Mohamed Premier 0 0 1 0 0 0 0 0 1
Genomic Center, National Cancer Institute 1 0 0 0 0 0 0 0 1
Department of Medical Oncology, City of Hope 1 0 0 0 0 0 0 0 1
Molecular Oncology - Human Genetics Lab, University of Sao Paulo 0 0 1 0 0 0 0 0 1
Pathology Department, Puerta del Mar University Hospital 0 0 1 0 0 0 0 0 1

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