ClinVar Miner

Variants in gene MET

Minimum submission review status: Collection method:
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Gene type:
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If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign risk factor other not provided total
12 15 446 220 50 3 1 30 682

Condition and significance breakdown #

Total conditions: 17
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Condition pathogenic likely pathogenic uncertain significance likely benign benign risk factor other not provided total
Renal cell carcinoma, papillary, 1 8 0 373 165 44 0 0 0 568
Hereditary cancer-predisposing syndrome 3 0 112 68 13 0 0 0 194
not specified 0 0 3 37 19 0 0 30 72
not provided 1 0 44 1 11 0 0 0 56
Osteofibrous dysplasia; Renal cell carcinoma, papillary, 1; Hepatocellular carcinoma; Deafness, autosomal recessive 97 0 0 10 0 0 0 0 0 10
Carcinoma 0 9 0 0 0 0 0 0 9
Neoplasm 0 8 0 0 0 0 0 0 8
Kidney Carcinoma 0 5 0 0 0 0 0 0 5
Childhood hepatocellular carcinoma 3 0 0 0 0 0 0 0 3
Osteofibrous dysplasia 0 0 0 0 0 2 0 0 2
Autism 9 0 0 1 0 0 0 0 0 1
Congenital diaphragmatic hernia 0 0 1 0 0 0 0 0 1
Deafness, autosomal recessive 97 1 0 0 0 0 0 0 0 1
Distal arthrogryposis type 1A 0 0 0 0 0 1 0 0 1
Lymphoedema 0 0 0 1 0 0 0 0 1
Neuroblastoma 0 0 0 0 0 0 1 0 1
Nonsyndromic Hearing Loss and Deafness, Autosomal Recessive 1 0 0 0 0 0 0 0 1

Submitter and significance breakdown #

Total submitters: 25
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Submitter pathogenic likely pathogenic uncertain significance likely benign benign risk factor other not provided total
Invitae 1 0 321 127 36 0 0 0 485
Ambry Genetics 3 0 111 68 12 0 0 0 194
Illumina Clinical Services Laboratory,Illumina 0 0 31 41 13 0 0 0 85
GeneDx 1 0 9 35 11 0 0 0 56
Mendelics 1 0 48 4 1 0 0 0 54
EGL Genetic Diagnostics,Eurofins Clinical Diagnostics 1 0 17 1 15 0 0 0 34
ITMI 0 0 0 0 0 0 0 30 30
Biesecker Lab/Human Development Section,National Institutes of Health 0 0 20 0 4 0 0 0 24
PreventionGenetics 0 0 0 3 15 0 0 0 18
Database of Curated Mutations (DoCM) 0 15 0 0 0 0 0 0 15
OMIM 11 0 1 0 0 2 0 0 14
Integrated Genetics/Laboratory Corporation of America 0 0 1 0 11 0 0 0 12
Fulgent Genetics 0 0 10 0 0 0 0 0 10
ARUP Laboratories, Molecular Genetics and Genomics,ARUP Laboratories 0 0 0 2 3 0 0 0 5
Vantari Genetics 0 0 3 1 1 0 0 0 5
Athena Diagnostics Inc 0 0 0 0 1 0 0 0 1
Laboratory for Molecular Medicine,Partners HealthCare Personalized Medicine 0 0 1 0 0 0 0 0 1
Institute of Human Genetics,Cologne University 0 0 1 0 0 0 0 0 1
CSER_CC_NCGL; University of Washington Medical Center 0 0 0 1 0 0 0 0 1
School of Biological Sciences, University of the Punjab 1 0 0 0 0 0 0 0 1
Lupski Lab, Baylor-Hopkins CMG,Baylor College of Medicine 0 0 1 0 0 0 0 0 1
Center for Pediatric Genomic Medicine,Children's Mercy Hospital and Clinics 0 0 0 1 0 0 0 0 1
Donald Williams Parsons Laboratory,Baylor College of Medicine 0 0 0 0 0 0 1 0 1
CeGaT Praxis fuer Humangenetik Tuebingen 0 0 1 0 0 0 0 0 1
The Spine Surgery of The First Affiliated Hospital,Sun Yat-sen University 0 0 0 0 0 1 0 0 1

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