ClinVar Miner

Variants in gene MET

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Minimum submission review status: Collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign risk factor other not provided total
16 8 2697 1800 672 3 1 38 4348

Condition and significance breakdown #

Total conditions: 30
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Condition pathogenic likely pathogenic uncertain significance likely benign benign risk factor other not provided total
Renal cell carcinoma 3 2 1855 1159 59 0 0 2 3077
Hereditary cancer-predisposing syndrome 4 2 1395 1030 58 0 0 0 2455
Papillary renal cell carcinoma type 1 8 2 142 201 576 0 0 1 897
not provided 3 0 410 87 48 0 0 5 536
not specified 0 0 78 116 39 0 0 30 234
Autosomal recessive nonsyndromic hearing loss 97 1 0 203 0 5 0 0 0 209
MET-related disorder 1 0 37 60 2 0 0 0 100
Osteofibrous dysplasia; Papillary renal cell carcinoma type 1; Hepatocellular carcinoma; Autosomal recessive nonsyndromic hearing loss 97; Arthrogryposis, distal, IIa 11 0 1 41 5 6 0 0 0 53
Osteofibrous dysplasia; Papillary renal cell carcinoma type 1; Hepatocellular carcinoma; Autosomal recessive nonsyndromic hearing loss 97 0 0 23 1 0 0 0 0 24
Hereditary cancer 0 0 2 15 0 0 0 0 17
Osteofibrous dysplasia 0 0 6 0 0 2 0 0 8
Ovarian cancer 0 2 0 0 5 0 0 0 7
Intellectual disability 0 0 1 3 0 0 0 0 4
Arthrogryposis, distal, IIa 11 1 0 2 0 0 0 0 0 3
Pediatric hepatocellular carcinoma 3 0 0 0 0 0 0 0 3
Lymphedema 0 0 1 1 0 0 0 0 2
Nonsyndromic genetic hearing loss 0 0 1 1 0 0 0 0 2
Arthrogryposis, distal, type 1A 0 0 0 0 0 1 0 0 1
Breast carcinoma 0 0 1 0 0 0 0 0 1
Classic Hodgkin lymphoma 0 0 1 0 0 0 0 0 1
Colorectal cancer 1 0 0 0 0 0 0 0 1
Congenital diaphragmatic hernia 0 0 1 0 0 0 0 0 1
Hepatoblastoma 0 0 1 0 0 0 0 0 1
Hereditary papillary renal cell carcinoma 0 0 1 0 0 0 0 0 1
Lung carcinoma 1 0 0 0 0 0 0 0 1
Neuroblastoma 0 0 0 0 0 0 1 0 1
Nonsyndromic Hearing Loss and Deafness, Autosomal Recessive 1 0 0 0 0 0 0 0 1
Osteofibrous dysplasia; Papillary renal cell carcinoma type 1; Autosomal recessive nonsyndromic hearing loss 97; Arthrogryposis, distal, IIa 11 0 0 1 0 0 0 0 0 1
Papillary renal cell carcinoma type 1; Hepatocellular carcinoma 0 0 1 0 0 0 0 0 1
Squamous cell lung carcinoma 0 0 1 0 0 0 0 0 1

Submitter and significance breakdown #

Total submitters: 66
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Submitter pathogenic likely pathogenic uncertain significance likely benign benign risk factor other not provided total
Labcorp Genetics (formerly Invitae), Labcorp 3 1 1862 1163 58 0 0 0 3087
Ambry Genetics 4 2 1365 1024 51 0 0 0 2446
Myriad Genetics, Inc. 0 1 0 172 529 0 0 0 702
GeneDx 1 0 336 85 37 0 0 0 459
Baylor Genetics 0 0 209 0 0 0 0 0 209
Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital 1 0 65 95 20 0 0 0 181
Illumina Laboratory Services, Illumina 0 0 60 15 57 0 0 0 132
PreventionGenetics, part of Exact Sciences 1 0 37 62 17 0 0 0 117
Sema4, Sema4 0 0 44 39 10 0 0 0 93
Mendelics 1 0 44 32 8 0 0 0 85
Quest Diagnostics Nichols Institute San Juan Capistrano 0 0 73 0 3 0 0 0 76
Fulgent Genetics, Fulgent Genetics 0 0 55 1 0 0 0 0 56
Breakthrough Genomics, Breakthrough Genomics 0 0 6 13 26 0 0 0 45
Eurofins Ntd Llc (ga) 1 0 17 1 15 0 0 0 34
Department of Pathology and Laboratory Medicine, Sinai Health System 0 2 13 7 10 0 0 0 32
St. Jude Molecular Pathology, St. Jude Children's Research Hospital 0 0 30 0 1 0 0 0 31
ITMI 0 0 0 0 0 0 0 30 30
CeGaT Center for Human Genetics Tuebingen 0 0 6 18 4 0 0 0 28
Women's Health and Genetics/Laboratory Corporation of America, LabCorp 0 0 6 4 17 0 0 0 27
KCCC/NGS Laboratory, Kuwait Cancer Control Center 0 0 0 5 21 0 0 0 26
Biesecker Lab/Clinical Genomics Section, National Institutes of Health 0 0 19 0 5 0 0 0 24
ARUP Laboratories, Molecular Genetics and Genomics, ARUP Laboratories 0 0 7 2 10 0 0 0 19
Clinical Genetics, Academic Medical Center 0 0 0 5 14 0 0 0 19
Institute for Clinical Genetics, University Hospital TU Dresden, University Hospital TU Dresden 0 0 17 0 0 0 0 0 17
OMIM 12 0 0 0 0 2 0 0 14
Joint Genome Diagnostic Labs from Nijmegen and Maastricht, Radboudumc and MUMC+ 0 0 0 1 12 0 0 0 13
Genetic Services Laboratory, University of Chicago 0 0 2 5 2 0 0 0 9
Revvity Omics, Revvity 1 0 8 0 0 0 0 0 9
Genome Diagnostics Laboratory, University Medical Center Utrecht 1 0 0 1 7 0 0 0 9
Genome Diagnostics Laboratory, Amsterdam University Medical Center 1 0 0 4 3 0 0 0 8
Clinical Genetics DNA and cytogenetics Diagnostics Lab, Erasmus MC, Erasmus Medical Center 0 0 1 6 1 0 0 0 8
Diagnostic Laboratory, Department of Genetics, University Medical Center Groningen 0 0 1 2 4 0 0 0 7
Laboratory of Molecular Epidemiology of Birth Defects, West China Second University Hospital, Sichuan University 0 2 0 0 5 0 0 0 7
Athena Diagnostics 0 0 1 0 5 0 0 0 6
Vantari Genetics 0 0 3 1 1 0 0 0 5
MutSpliceDB: a database of splice sites variants effects on splicing, NIH 0 0 0 0 0 0 0 5 5
Genome-Nilou Lab 0 0 0 0 5 0 0 0 5
Centre de Biologie Pathologie Génétique, Centre Hospitalier Universitaire de Lille 0 0 1 3 0 0 0 0 4
Mayo Clinic Laboratories, Mayo Clinic 0 0 3 0 0 0 0 0 3
Clinical Genomics Laboratory, Washington University in St. Louis 0 0 3 0 0 0 0 0 3
GenomeConnect - Invitae Patient Insights Network 0 0 0 0 0 0 0 3 3
Institute of Human Genetics, University of Leipzig Medical Center 0 0 1 1 0 0 0 0 2
Neuberg Centre For Genomic Medicine, NCGM 0 0 2 0 0 0 0 0 2
Molecular Diagnostics Laboratory, Catalan Institute of Oncology 0 0 0 1 1 0 0 0 2
Laboratorio de Genetica e Diagnostico Molecular, Hospital Israelita Albert Einstein 0 0 2 0 0 0 0 0 2
Institute of Human Genetics, University of Goettingen 0 0 1 0 0 0 0 0 1
Laboratory for Molecular Medicine, Mass General Brigham Personalized Medicine 0 0 1 0 0 0 0 0 1
Institute of Human Genetics, Cologne University 0 0 1 0 0 0 0 0 1
MGZ Medical Genetics Center 0 0 1 0 0 0 0 0 1
Genomic Medicine Center of Excellence, King Faisal Specialist Hospital and Research Centre 0 0 0 0 1 0 0 0 1
CSER _CC_NCGL, University of Washington 0 0 0 1 0 0 0 0 1
School of Biological Sciences, University of the Punjab 1 0 0 0 0 0 0 0 1
Lupski Lab, Baylor-Hopkins CMG, Baylor College of Medicine 0 0 1 0 0 0 0 0 1
Center for Pediatric Genomic Medicine, Children's Mercy Hospital and Clinics 0 0 0 1 0 0 0 0 1
Donald Williams Parsons Laboratory, Baylor College of Medicine 0 0 0 0 0 0 1 0 1
Genetics and Molecular Pathology, SA Pathology 0 0 0 0 1 0 0 0 1
The Spine Surgery of The First Affiliated Hospital, Sun Yat-sen University 0 0 0 0 0 1 0 0 1
Laboratory of Diagnostic Genome Analysis, Leiden University Medical Center (LUMC) 0 0 0 1 0 0 0 0 1
Clinical Genetics Laboratory, Department of Pathology, Netherlands Cancer Institute 0 0 0 0 1 0 0 0 1
Al Jalila Children’s Genomics Center, Al Jalila Childrens Speciality Hospital 0 1 0 0 0 0 0 0 1
Faculté Pluridciplinaire Nador, Université Mohamed Premier 0 0 1 0 0 0 0 0 1
Genomic Center, National Cancer Institute 1 0 0 0 0 0 0 0 1
Department of Medical Oncology, City of Hope 1 0 0 0 0 0 0 0 1
Department of Human Genetics, Hannover Medical School 0 0 1 0 0 0 0 0 1
Molecular Oncology - Human Genetics Lab, University of Sao Paulo 0 0 1 0 0 0 0 0 1
Pathology Department, Puerta del Mar University Hospital 0 0 1 0 0 0 0 0 1

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