ClinVar Miner

Variants in gene MET

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Minimum submission review status: Collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign risk factor other not provided total
14 16 1019 432 89 3 1 35 1470

Condition and significance breakdown #

Total conditions: 24
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Condition pathogenic likely pathogenic uncertain significance likely benign benign risk factor other not provided total
Renal cell carcinoma 2 1 651 195 0 0 0 0 849
Renal cell carcinoma, papillary, 1 8 0 335 115 79 0 0 0 519
Hereditary cancer-predisposing syndrome 3 0 271 161 15 0 0 0 447
not provided 1 0 50 88 15 0 0 5 157
not specified 0 0 4 37 20 0 0 30 73
none provided 0 0 1 1 9 0 0 0 11
Osteofibrous dysplasia; Renal cell carcinoma, papillary, 1; Hepatocellular carcinoma; Deafness, autosomal recessive 97 0 0 10 0 0 0 0 0 10
Carcinoma 0 9 0 0 0 0 0 0 9
Neoplasm 0 8 0 0 0 0 0 0 8
Osteofibrous dysplasia 0 0 4 0 0 2 0 0 6
Kidney Carcinoma 0 5 0 0 0 0 0 0 5
Intellectual disability 0 0 1 3 0 0 0 0 4
Childhood hepatocellular carcinoma 3 0 0 0 0 0 0 0 3
Deafness, autosomal recessive 97 1 0 2 0 0 0 0 0 3
Breast carcinoma 0 0 1 0 0 0 0 0 1
Colorectal cancer 1 0 0 0 0 0 0 0 1
Congenital diaphragmatic hernia 0 0 1 0 0 0 0 0 1
Distal arthrogryposis type 1A 0 0 0 0 0 1 0 0 1
Familial mediterranean fever, autosomal dominant 0 0 0 1 0 0 0 0 1
Lung carcinoma 1 0 0 0 0 0 0 0 1
Lymphedema 0 0 0 1 0 0 0 0 1
Neuroblastoma 0 0 0 0 0 0 1 0 1
Nonsyndromic Hearing Loss and Deafness, Autosomal Recessive 1 0 0 0 0 0 0 0 1
Squamous cell lung carcinoma 0 0 1 0 0 0 0 0 1

Submitter and significance breakdown #

Total submitters: 33
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Submitter pathogenic likely pathogenic uncertain significance likely benign benign risk factor other not provided total
Invitae 3 1 850 322 39 0 0 0 1215
Ambry Genetics 3 0 269 161 14 0 0 0 447
Illumina Clinical Services Laboratory,Illumina 0 0 60 15 57 0 0 0 132
Mendelics 1 0 56 17 4 0 0 0 78
GeneDx 1 0 9 52 15 0 0 0 77
EGL Genetic Diagnostics, Eurofins Clinical Diagnostics 1 0 17 1 15 0 0 0 34
ITMI 0 0 0 0 0 0 0 30 30
Biesecker Lab/Clinical Genomics Section,National Institutes of Health 0 0 20 0 4 0 0 0 24
PreventionGenetics, PreventionGenetics 0 0 0 3 15 0 0 0 18
Database of Curated Mutations (DoCM) 0 15 0 0 0 0 0 0 15
Integrated Genetics/Laboratory Corporation of America 0 0 2 0 12 0 0 0 14
OMIM 11 0 0 0 0 2 0 0 13
ARUP Laboratories, Molecular Genetics and Genomics,ARUP Laboratories 0 0 1 1 10 0 0 0 12
Fulgent Genetics,Fulgent Genetics 0 0 10 0 0 0 0 0 10
CeGaT Praxis fuer Humangenetik Tuebingen 0 0 7 2 0 0 0 0 9
Baylor Genetics 0 0 7 0 0 0 0 0 7
Athena Diagnostics Inc 0 0 1 0 5 0 0 0 6
Vantari Genetics 0 0 3 1 1 0 0 0 5
MutSpliceDB: a database of splice sites variants effects on splicing,NIH 0 0 0 0 0 0 0 5 5
Centre de Biologie Pathologie Génétique, Centre Hospitalier Universitaire de Lille 0 0 1 3 0 0 0 0 4
Institute of Human Genetics, University of Leipzig Medical Center 0 0 1 1 0 0 0 0 2
Laboratory for Molecular Medicine,Partners HealthCare Personalized Medicine 0 0 1 0 0 0 0 0 1
Institute of Human Genetics,Cologne University 0 0 1 0 0 0 0 0 1
CSER _CC_NCGL, University of Washington 0 0 0 1 0 0 0 0 1
School of Biological Sciences, University of the Punjab 1 0 0 0 0 0 0 0 1
Lupski Lab, Baylor-Hopkins CMG, Baylor College of Medicine 0 0 1 0 0 0 0 0 1
Center for Pediatric Genomic Medicine,Children's Mercy Hospital and Clinics 0 0 0 1 0 0 0 0 1
Donald Williams Parsons Laboratory,Baylor College of Medicine 0 0 0 0 0 0 1 0 1
Department of Pathology and Laboratory Medicine,Sinai Health System 0 0 1 0 0 0 0 0 1
The Spine Surgery of The First Affiliated Hospital,Sun Yat-sen University 0 0 0 0 0 1 0 0 1
Faculté Pluridciplinaire Nador,Université Mohamed Premier 0 0 1 0 0 0 0 0 1
Genomic Center,National Cancer Institute 1 0 0 0 0 0 0 0 1
Department of Medical Oncology,City of Hope 1 0 0 0 0 0 0 0 1

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