ClinVar Miner

Variants in gene MYO15A

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Minimum submission review status: Collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign not provided total
482 355 1179 1851 231 5 3563

Condition and significance breakdown #

Total conditions: 17
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Condition pathogenic likely pathogenic uncertain significance likely benign benign not provided total
not provided 284 111 609 1809 227 0 2807
Autosomal recessive nonsyndromic hearing loss 3 241 234 370 22 43 5 838
Inborn genetic diseases 7 1 359 22 0 0 389
not specified 0 2 148 142 73 0 353
MYO15A-related disorder 6 10 17 56 8 0 97
Rare genetic deafness 27 20 2 0 0 0 49
Hearing impairment 3 7 10 0 0 0 20
Hearing loss, autosomal recessive 3 9 7 0 0 0 19
Nonsyndromic genetic hearing loss 5 4 1 4 2 0 16
Childhood onset hearing loss 0 1 5 0 0 0 6
Ear malformation 2 4 0 0 0 0 6
Congenital sensorineural hearing impairment 1 1 1 0 0 0 3
Alport syndrome 0 0 1 0 0 0 1
Autosomal recessive nonsyndromic hearing loss 9 0 1 0 0 0 0 1
Deafness, with smith-magenis syndrome 1 0 0 0 0 0 1
Nonsyndromic genetic hearing loss; Rare genetic deafness 1 0 0 0 0 0 1
Sensorineural hearing loss disorder 1 0 0 0 0 0 1

Submitter and significance breakdown #

Total submitters: 97
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Submitter pathogenic likely pathogenic uncertain significance likely benign benign not provided total
Labcorp Genetics (formerly Invitae), Labcorp 263 56 230 1698 153 0 2400
GeneDx 46 43 346 159 131 0 725
Ambry Genetics 7 1 359 22 0 0 389
Laboratory for Molecular Medicine, Mass General Brigham Personalized Medicine 28 21 117 113 69 0 348
Illumina Laboratory Services, Illumina 3 3 253 11 24 0 294
Institute of Rare Diseases, West China Hospital, Sichuan University 60 91 0 0 0 0 151
PreventionGenetics, part of Exact Sciences 6 10 17 63 33 0 129
CeGaT Center for Human Genetics Tuebingen 8 8 39 59 5 0 119
Breakthrough Genomics, Breakthrough Genomics 1 0 9 37 71 0 118
Molecular Diagnosis Center for Deafness 53 21 28 0 1 0 103
Eurofins Ntd Llc (ga) 6 1 52 8 19 0 86
Fulgent Genetics, Fulgent Genetics 14 48 23 0 1 0 86
Women's Health and Genetics/Laboratory Corporation of America, LabCorp 16 8 27 4 0 0 55
ARUP Laboratories, Molecular Genetics and Genomics, ARUP Laboratories 0 3 22 6 19 0 50
Department of Pathology and Laboratory Medicine, Sinai Health System 1 4 24 2 0 0 31
Athena Diagnostics 1 1 12 6 8 0 28
Deafness Molecular Diagnostic Center, Chinese PLA General Hospital 12 6 8 0 0 0 26
Joint Genome Diagnostic Labs from Nijmegen and Maastricht, Radboudumc and MUMC+ 4 2 3 1 15 0 25
ENT and Head and Neck Research Center and Department, The Five Senses Health Institute, Iran University of Medical Sciences 19 6 0 0 0 0 25
Laboratory of Prof. Karen Avraham, Tel Aviv University 18 1 0 0 0 0 19
3billion 6 6 7 0 0 0 19
Department of Otolaryngology – Head & Neck Surgery, Cochlear Implant Center 3 5 11 0 0 0 19
Clinical Genetics DNA and cytogenetics Diagnostics Lab, Erasmus MC, Erasmus Medical Center 5 2 4 2 5 0 18
Genome-Nilou Lab 0 0 0 0 18 0 18
National Institute on Deafness and Communication Disorders, National Institutes of Health 9 2 6 0 0 0 17
Revvity Omics, Revvity 3 2 10 1 0 0 16
Juno Genomics, Hangzhou Juno Genomics, Inc 4 7 5 0 0 0 16
Victorian Clinical Genetics Services, Murdoch Childrens Research Institute 4 10 1 0 0 0 15
Diagnostic Laboratory, Department of Genetics, University Medical Center Groningen 0 0 0 0 15 0 15
ClinGen Hearing Loss Variant Curation Expert Panel 5 3 1 3 2 0 14
OMIM 13 0 0 0 0 0 13
Baylor Genetics 0 0 13 0 0 0 13
Genetic Testing Center for Deafness, Department of Otolaryngology Head & Neck Surgery, Institute of Otolaryngology, Chinese PLA General Hospital 5 6 2 0 0 0 13
Center for Statistical Genetics, Columbia University 10 2 0 0 0 0 12
Division of Human Genetics, Children's Hospital of Philadelphia 4 1 5 0 0 1 11
Neuberg Centre For Genomic Medicine, NCGM 0 3 7 0 0 0 10
WangQJ Lab, Chinese People's Liberation Army General Hospital 1 2 6 0 0 0 9
Mayo Clinic Laboratories, Mayo Clinic 0 3 5 0 0 0 8
King Laboratory, University of Washington 3 3 0 0 0 0 6
Mendelics 2 0 2 2 0 0 6
Genomic Medicine Center of Excellence, King Faisal Specialist Hospital and Research Centre 1 1 4 0 0 0 6
University of Washington Center for Mendelian Genomics, University of Washington 0 6 0 0 0 0 6
Kariminejad - Najmabadi Pathology & Genetics Center 2 4 0 0 0 0 6
Clinical Genetics Laboratory, Skane University Hospital Lund 1 3 2 0 0 0 6
Center For Human Genetics And Laboratory Diagnostics, Dr. Klein, Dr. Rost And Colleagues 4 1 0 0 0 0 5
Hereditary Research Laboratory, Bethlehem University 4 0 0 0 0 0 4
Centre for Mendelian Genomics, University Medical Centre Ljubljana 1 2 1 0 0 0 4
Institute of Human Genetics, University of Leipzig Medical Center 1 1 1 1 0 0 4
GenomeConnect, ClinGen 0 0 0 0 0 4 4
Wonkam Laboratory, Johns Hopkins University 4 0 0 0 0 0 4
Genomic Diagnostic Laboratory, Division of Genomic Diagnostics, Children's Hospital of Philadelphia 1 0 2 0 0 0 3
Genomic Research Center, Shahid Beheshti University of Medical Sciences 2 1 1 0 0 0 3
Laboratory of Human Genetics, Universidade de São Paulo 2 1 0 0 0 0 3
Bioscientia Institut fuer Medizinische Diagnostik GmbH, Sonic Healthcare 2 0 1 0 0 0 3
Daryl Scott Lab, Baylor College of Medicine 0 0 3 0 0 0 3
Laboratory of Molecular Genetics, Brain Korea 21 PLUS Project for Medical Sciences, Yonsei University College of Medicine 3 0 0 0 0 0 3
Al Jalila Children’s Genomics Center, Al Jalila Childrens Speciality Hospital 0 0 3 0 0 0 3
Greenwood Genetic Center Diagnostic Laboratories, Greenwood Genetic Center 0 0 2 0 0 0 2
Genetic Services Laboratory, University of Chicago 1 1 0 0 0 0 2
Laboratory of Genetic Epidemiology, Research Centre for Medical Genetics 0 2 0 0 0 0 2
Knight Diagnostic Laboratories, Oregon Health and Sciences University 0 1 1 0 0 0 2
Institute for Clinical Genetics, University Hospital TU Dresden, University Hospital TU Dresden 0 0 2 0 0 0 2
Center for Pediatric Genomic Medicine, Children's Mercy Hospital and Clinics 0 0 0 2 0 0 2
Hereditary Hearing Loss Research Unit, University of Madras 1 1 0 0 0 0 2
Yale Center for Mendelian Genomics, Yale University 0 2 0 0 0 0 2
Biochemical Molecular Genetic Laboratory, King Abdulaziz Medical City 0 1 1 0 0 0 2
Otorhinolaryngology Lab - LIM32, University of Sao Paulo School of Medicine Clinics Hospital 2 0 0 0 0 0 2
Department Of Genetics, Sultan Qaboos University Hospital, Sultan Qaboos University 2 0 0 0 0 0 2
Genetics Laboratory, Department of Biology, Semnan University 2 0 0 0 0 0 2
Zotz-Klimas Genetics Lab, MVZ Zotz Klimas 0 1 1 0 0 0 2
Diagnostics Services (NGS), CSIR - Centre For Cellular And Molecular Biology 1 0 1 0 0 0 2
Pittsburgh Clinical Genomics Laboratory, University of Pittsburgh Medical Center 0 1 1 0 0 0 2
Neurogenetic Laboratory, Second Faculty of Medicine, Charles University 0 1 1 0 0 0 2
The Shared Resource Centre "Genome", Research Centre for Medical Genetics 1 1 0 0 0 0 2
MVZ Medizinische Genetik Mainz 1 0 1 0 0 0 2
Shenzhen Maternity and Child Healthcare Hospital, Institute of Maternal and Child Medicine Research 2 0 0 0 0 0 2
Institute of Human Genetics, University of Goettingen 0 1 0 0 0 0 1
Clinical Genetics and Genomics, Karolinska University Hospital 0 1 0 0 0 0 1
Center of Genomic medicine, Geneva, University Hospital of Geneva 1 0 0 0 0 0 1
Laboratory of Molecular Genetics, National Institutes of Health 0 1 0 0 0 0 1
Medical Molecular Genetics Department, National Research Center 0 1 0 0 0 0 1
Institute of Human Genetics, University of Wuerzburg 0 0 1 0 0 0 1
Equipe Genetique des Anomalies du Developpement, Université de Bourgogne 0 1 0 0 0 0 1
Santos-Cortez Lab, University of Colorado School of Medicine 0 1 0 0 0 0 1
Center for Personalized Medicine, Children's Hospital Los Angeles 0 0 1 0 0 0 1
Institute of Medical Genetics and Applied Genomics, University Hospital Tübingen 1 0 0 0 0 0 1
Laboratory of Diagnostic Genome Analysis, Leiden University Medical Center (LUMC) 0 0 0 1 0 0 1
The Genetic Institute, Ha'emek Medical center, Ha'emek Medical Center 1 0 0 0 0 0 1
Genetics and Genomic Medicine Centre, NeuroGen Healthcare, NeuroGen Healthcare 0 1 0 0 0 0 1
Lifecell International Pvt. Ltd 0 1 0 0 0 0 1
Molecular Genetics, Royal Melbourne Hospital 0 0 0 1 0 0 1
Department of Genetics, Dr. ALM PG Institute of Basic Medical Sciences 0 0 1 0 0 0 1
Payam Genetics Center, General Welfare Department of North Khorasan Province 1 0 0 0 0 0 1
UAEU Genomics Laboratory, United Arab Emirates University 0 1 0 0 0 0 1
Dr.Nikuei Genetic Center 1 0 0 0 0 0 1
Laboratory of Dr. Barbara Vona, University Medical Center Göttingen 1 0 0 0 0 0 1
Clinical Genomics, G42 Labs 1 0 0 0 0 0 1

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