ClinVar Miner

Variants in gene TNFRSF13B

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If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign established risk allele risk factor not provided total
37 19 205 120 25 2 1 5 361

Condition and significance breakdown #

Total conditions: 16
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Condition pathogenic likely pathogenic uncertain significance likely benign benign established risk allele risk factor not provided total
Immunodeficiency, common variable, 2 35 12 172 108 16 2 1 1 324
not provided 9 8 46 12 11 0 0 2 74
not specified 2 1 9 6 14 0 0 0 31
Inborn genetic diseases 0 0 26 2 0 0 0 0 28
TNFRSF13B-related disorder 2 7 8 5 1 0 0 0 22
Common Variable Immune Deficiency, Dominant 0 0 8 8 5 0 0 0 21
Immunodeficiency, common variable, 2; Immunoglobulin A deficiency 2 1 4 10 1 0 0 0 0 16
Immunoglobulin A deficiency 2 6 0 2 0 0 0 0 0 8
Common variable immunodeficiency 1 3 0 0 0 0 0 0 4
Immunodeficiency, common variable, 1 2 2 0 0 0 0 0 0 4
Hyper-IgM syndrome type 2 1 0 0 0 0 0 0 0 1
IgAD1; Immunodeficiency, common variable, 2 0 0 0 0 0 0 0 1 1
Immune deficiency, familial variable 1 0 0 0 0 0 0 0 1
Immunodeficiency, common variable, 1; Immunodeficiency, common variable, 2 0 0 0 0 0 0 0 1 1
See cases 0 1 0 0 0 0 0 0 1
Severe SARS-CoV-2 infection, susceptibility to 0 1 0 0 0 0 0 0 1

Submitter and significance breakdown #

Total submitters: 72
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Submitter pathogenic likely pathogenic uncertain significance likely benign benign established risk allele risk factor not provided total
Labcorp Genetics (formerly Invitae), Labcorp 32 3 157 107 15 0 0 0 314
GeneDx 6 4 24 1 6 0 0 0 41
CeGaT Center for Human Genetics Tuebingen 6 2 18 5 0 0 0 0 31
Ambry Genetics 0 0 26 2 0 0 0 0 28
PreventionGenetics, part of Exact Sciences 2 6 8 5 4 0 0 0 25
ARUP Laboratories, Molecular Genetics and Genomics, ARUP Laboratories 5 2 5 5 6 0 0 0 23
Illumina Laboratory Services, Illumina 0 0 8 8 5 0 0 0 21
Women's Health and Genetics/Laboratory Corporation of America, LabCorp 1 2 4 5 8 0 0 0 20
Breakthrough Genomics, Breakthrough Genomics 0 0 6 5 6 0 0 0 17
Baylor Genetics 4 2 6 0 0 0 0 0 12
Department of Pathology and Laboratory Medicine, Sinai Health System 1 5 4 0 0 2 0 0 12
Fulgent Genetics, Fulgent Genetics 0 2 6 0 0 0 0 0 8
Laboratorio de Genetica e Diagnostico Molecular, Hospital Israelita Albert Einstein 0 3 5 0 0 0 0 0 8
Revvity Omics, Revvity 2 3 2 0 0 0 0 0 7
Center for Genomics, Ann and Robert H. Lurie Children's Hospital of Chicago 1 2 3 1 0 0 0 0 7
OMIM 6 0 0 0 0 0 0 0 6
Laboratory for Molecular Medicine, Mass General Brigham Personalized Medicine 0 0 1 1 4 0 0 0 6
Blueprint Genetics 0 0 6 0 0 0 0 0 6
Genetic Services Laboratory, University of Chicago 0 2 1 0 2 0 0 0 5
Mendelics 2 1 2 0 0 0 0 0 5
Institute of Human Genetics, University of Leipzig Medical Center 2 2 1 0 0 0 0 0 5
Unidad de Genómica Garrahan, Hospital de Pediatría Garrahan 0 0 0 0 5 0 0 0 5
3billion 3 1 1 0 0 0 0 0 5
Clinic of Clinical Immunology with Stem Cell Bank, Expert Centre for Rare Diseases - PID, University Hospital "Alexandrovska" 3 3 0 0 0 0 0 0 5
Genome Diagnostics Laboratory, University Medical Center Utrecht 1 1 0 2 0 0 0 0 4
Mayo Clinic Laboratories, Mayo Clinic 2 1 1 0 0 0 0 0 4
Genomic Medicine Center of Excellence, King Faisal Specialist Hospital and Research Centre 1 1 2 0 0 0 0 0 4
Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital 0 2 2 0 0 0 0 0 4
GenomeConnect, ClinGen 0 0 0 0 0 0 0 4 4
Clinical Genomics Laboratory, Washington University in St. Louis 2 0 1 0 0 0 0 0 3
Diagnostic Laboratory, Department of Genetics, University Medical Center Groningen 0 2 0 1 0 0 0 0 3
Clinical Genetics DNA and cytogenetics Diagnostics Lab, Erasmus MC, Erasmus Medical Center 0 2 0 1 0 0 0 0 3
Al Jalila Children’s Genomics Center, Al Jalila Childrens Speciality Hospital 0 0 3 0 0 0 0 0 3
New York Genome Center 0 0 3 0 0 0 0 0 3
Genome-Nilou Lab 0 0 0 0 3 0 0 0 3
Greenwood Genetic Center Diagnostic Laboratories, Greenwood Genetic Center 1 1 0 0 0 0 0 0 2
Eurofins Ntd Llc (ga) 0 0 2 0 0 0 0 0 2
Victorian Clinical Genetics Services, Murdoch Childrens Research Institute 1 0 1 0 0 0 0 0 2
Center for Pediatric Genomic Medicine, Children's Mercy Hospital and Clinics 0 0 0 2 0 0 0 0 2
Joint Genome Diagnostic Labs from Nijmegen and Maastricht, Radboudumc and MUMC+ 0 2 0 0 0 0 0 0 2
Center for Personalized Medicine, Children's Hospital Los Angeles 0 0 2 0 0 0 0 0 2
Institute of Medical Genetics and Applied Genomics, University Hospital Tübingen 0 2 0 0 0 0 0 0 2
Laboratory of Diagnostic Genome Analysis, Leiden University Medical Center (LUMC) 0 0 0 2 0 0 0 0 2
Genome Diagnostics Laboratory, Amsterdam University Medical Center 0 2 0 0 0 0 0 0 2
AiLife Diagnostics, AiLife Diagnostics 2 0 0 0 0 0 0 0 2
Department of Human Genetics, Hannover Medical School 0 0 2 0 0 0 0 0 2
Institute of Immunology and Genetics Kaiserslautern 2 0 0 0 0 0 0 0 2
Molecular Genetics Laboratory, BC Children's and BC Women's Hospitals 1 0 0 0 0 0 0 0 1
Centogene AG - the Rare Disease Company 0 1 0 0 0 0 0 0 1
Institute of Human Genetics Munich, Klinikum Rechts Der Isar, TU München 1 0 0 0 0 0 0 0 1
UCLA Clinical Genomics Center, UCLA 0 1 0 0 0 0 0 0 1
Division of Human Genetics, Children's Hospital of Philadelphia 1 0 0 0 0 0 0 0 1
Knight Diagnostic Laboratories, Oregon Health and Sciences University 0 1 0 0 0 0 0 0 1
Center of Genomic medicine, Geneva, University Hospital of Geneva 0 0 0 0 0 0 1 0 1
Genetech, Genetech Research Institute 0 0 1 0 0 0 0 0 1
Centre for Mendelian Genomics, University Medical Centre Ljubljana 1 0 0 0 0 0 0 0 1
Rady Children's Institute for Genomic Medicine, Rady Children's Hospital San Diego 0 1 0 0 0 0 0 0 1
Biochemical Molecular Genetic Laboratory, King Abdulaziz Medical City 1 0 0 0 0 0 0 0 1
Laboratory of Medical Genetics, National & Kapodistrian University of Athens 0 1 0 0 0 0 0 0 1
St. Jude Molecular Pathology, St. Jude Children's Research Hospital 0 0 1 0 0 0 0 0 1
Genomic Medicine Lab, University of California San Francisco 1 0 0 0 0 0 0 0 1
Genetics and Genomic Medicine Centre, NeuroGen Healthcare, NeuroGen Healthcare 0 1 0 0 0 0 0 0 1
Breda Genetics srl 0 0 1 0 0 0 0 0 1
Institute for Genomic Statistics and Bioinformatics, University Hospital Bonn 0 1 0 0 0 0 0 0 1
Clinical Genomics Laboratory, Stanford Medicine 0 0 1 0 0 0 0 0 1
Pittsburgh Clinical Genomics Laboratory, University of Pittsburgh Medical Center 1 0 0 0 0 0 0 0 1
UOSD Laboratory of Genetics & Genomics of Rare Diseases, Istituto Giannina Gaslini 0 0 1 0 0 0 0 0 1
GenomeConnect - Invitae Patient Insights Network 0 0 0 0 0 0 0 1 1
Suma Genomics 0 0 1 0 0 0 0 0 1
Neuberg Centre For Genomic Medicine, NCGM 0 0 1 0 0 0 0 0 1
Pediatric Infectious Diseases and Immunodeficiencies Unit (UPIIP)- HUVH-VHIR, Vall d'Hebron University Hospital 0 1 0 0 0 0 0 0 1
Centre for Clinical Genetics and Genomic Diagnostics, Zealand University Hospital 0 1 0 0 0 0 0 0 1

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