ClinVar Miner

Variants studied for chronic leukemia

Included ClinVar conditions (10):
Minimum submission review status: Collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign not provided total
199 209 573 111 31 1 1116

Gene and significance breakdown #

Total genes and gene combinations: 24
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Gene or gene combination pathogenic likely pathogenic uncertain significance likely benign benign not provided total
NF1 134 92 493 84 1 0 801
PTPN11 41 11 29 18 14 0 111
CBL 5 4 42 5 15 0 68
TP53 2 55 0 0 0 0 57
FBXW7 0 10 0 0 0 0 10
NRAS 3 5 0 0 0 0 8
BRAF 0 7 0 0 0 0 7
HRAS, LRRC56 0 7 0 0 0 0 7
LOC111811965, MIR4733HG, NF1 1 0 5 1 0 0 7
KRAS 4 2 0 0 0 0 6
SF3B1 0 6 0 0 0 0 6
CBL, LOC130006895 0 0 1 3 1 0 5
ARHGAP26 3 0 0 0 0 0 3
PLCG2 0 3 0 0 0 0 3
XPO1 0 3 0 0 0 0 3
ASXL1 1 0 1 0 0 0 2
ATM 2 0 0 0 0 0 2
ATM, C11orf65 2 0 0 0 0 0 2
CBL, FRA11B, LOC130006894 0 0 2 0 0 0 2
SF3B2 0 2 0 0 0 0 2
BTK 0 0 0 0 0 1 1
ETV6, FLT3 0 1 0 0 0 0 1
EVI2A, NF1 1 0 0 0 0 0 1
MYD88 0 1 0 0 0 0 1

Submitter and significance breakdown #

Total submitters: 20
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Submitter pathogenic likely pathogenic uncertain significance likely benign benign not provided total
Baylor Genetics 88 68 371 1 0 0 528
Fulgent Genetics, Fulgent Genetics 59 17 210 107 4 0 397
Database of Curated Mutations (DoCM) 0 103 0 0 0 1 104
Juno Genomics, Hangzhou Juno Genomics, Inc 29 15 6 0 0 0 50
KCCC/NGS Laboratory, Kuwait Cancer Control Center 1 0 0 3 28 0 32
Center for Genomics, Ann and Robert H. Lurie Children's Hospital of Chicago 16 1 4 0 1 0 22
OMIM 20 0 0 0 0 0 20
Laboratory for Molecular Medicine, Mass General Brigham Personalized Medicine 15 1 0 0 0 0 16
NIHR Bioresource Rare Diseases, University of Cambridge 2 3 0 0 0 0 5
Molecular Genetics Lab, CHRU Brest 2 1 0 0 0 0 3
University Health Network, Princess Margaret Cancer Centre 2 0 0 0 0 0 2
Institute for Genomic Medicine (IGM) Clinical Laboratory, Nationwide Children's Hospital 1 0 0 0 0 0 1
Mendelics 0 1 0 0 0 0 1
Mayo Clinic Laboratories, Mayo Clinic 1 0 0 0 0 0 1
Genomic Research Center, Shahid Beheshti University of Medical Sciences 0 0 1 0 0 0 1
Genetics and Molecular Pathology, SA Pathology 0 0 1 0 0 0 1
Knight Cancer Institute, Oregon Health and Science University 0 1 0 0 0 0 1
Johns Hopkins Genomics, Johns Hopkins University 0 0 1 0 0 0 1
Diagnostics Services (NGS), CSIR - Centre For Cellular And Molecular Biology 1 0 0 0 0 0 1
Institute of Human Genetics, Clinical Exome/Genome Diagnostics Group, University Hospital Bonn 1 0 0 0 0 0 1

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