ClinVar Miner

Variants studied for breast-ovarian cancer, familial, susceptibility to, 3

Included ClinVar conditions (2):
Minimum submission review status: Collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign risk factor not provided total
123 97 182 46 12 7 7 416

Gene and significance breakdown #

Total genes and gene combinations: 6
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Gene or gene combination pathogenic likely pathogenic uncertain significance likely benign benign risk factor not provided total
RAD51C 107 85 167 39 12 7 6 371
LOC129390903, RAD51C 16 8 14 4 0 0 1 38
LOC130061310, RAD51C 0 3 1 1 0 0 0 4
RAD51C, TEX14 0 1 0 0 0 0 0 1
RAD51D, RAD51L3-RFFL 0 0 0 1 0 0 0 1
TP53 0 0 0 1 0 0 0 1

Submitter and significance breakdown #

Total submitters: 33
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Submitter pathogenic likely pathogenic uncertain significance likely benign benign risk factor not provided total
Myriad Genetics, Inc. 93 59 13 15 9 0 0 189
Baylor Genetics 27 37 98 0 0 0 0 162
Fulgent Genetics, Fulgent Genetics 11 7 47 12 0 0 0 77
Counsyl 9 7 29 14 5 0 0 63
Hereditary Cancer Group, L’Institut d'Investigació Biomèdica de Bellvitge 16 10 18 4 0 0 0 48
KCCC/NGS Laboratory, Kuwait Cancer Control Center 0 1 12 0 6 0 0 19
Illumina Laboratory Services, Illumina 0 0 9 3 1 0 0 13
Institute of Human Genetics, University of Leipzig Medical Center 5 1 5 1 0 0 0 12
St. Jude Molecular Pathology, St. Jude Children's Research Hospital 1 1 6 0 0 0 0 8
BRCAlab, Lund University 8 0 0 0 0 0 0 8
OMIM 0 0 0 0 0 7 0 7
MGZ Medical Genetics Center 2 2 2 0 0 0 0 6
Department of Molecular Diagnostics, Institute of Oncology Ljubljana 2 1 2 1 0 0 0 6
Genetics and Molecular Pathology, SA Pathology 1 0 3 1 0 0 0 5
Department of Pathology and Laboratory Medicine, Sinai Health System 3 1 1 0 0 0 0 5
GenomeConnect - Invitae Patient Insights Network 0 0 0 0 0 0 5 5
Centre for Mendelian Genomics, University Medical Centre Ljubljana 3 0 0 0 0 0 0 3
Division of Medical Genetics, University of Washington 0 1 2 0 0 0 0 3
Neuberg Centre For Genomic Medicine, NCGM 0 0 3 0 0 0 0 3
Laboratoire de Biologie et Génétique du Cancer, Centre François Baclesse 2 0 0 0 0 0 0 2
GenomeConnect, ClinGen 0 0 0 0 0 0 2 2
Center for Genomics, Ann and Robert H. Lurie Children's Hospital of Chicago 0 0 2 0 0 0 0 2
University of Washington Department of Laboratory Medicine, University of Washington 0 1 0 1 0 0 0 2
Dr. med. U. Finckh, Human Genetics, Eurofins MVZ 0 1 1 0 0 0 0 2
Center for Genomic Medicine, King Faisal Specialist Hospital and Research Center 0 0 0 0 2 0 0 2
Greenwood Genetic Center Diagnostic Laboratories, Greenwood Genetic Center 1 0 0 0 0 0 0 1
Genetic Services Laboratory, University of Chicago 1 0 0 0 0 0 0 1
Department of Obstetrics and Gynecology, Helsinki University Hospital 0 1 0 0 0 0 0 1
UNC Molecular Genetics Laboratory, University of North Carolina at Chapel Hill 1 0 0 0 0 0 0 1
Lifecell International Pvt. Ltd 0 1 0 0 0 0 0 1
Human Genetics Bochum, Ruhr University Bochum 0 1 0 0 0 0 0 1
Laboratorio de Genetica e Diagnostico Molecular, Hospital Israelita Albert Einstein 0 0 1 0 0 0 0 1
Institute of Immunology and Genetics Kaiserslautern 1 0 0 0 0 0 0 1

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