ClinVar Miner

Variants studied for thyroid tumor

Included ClinVar conditions (41):
Minimum submission review status: Collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign risk factor not provided total
126 76 1617 1180 86 1 8 2933

Gene and significance breakdown #

Total genes and gene combinations: 32
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Gene or gene combination pathogenic likely pathogenic uncertain significance likely benign benign risk factor not provided total
RET 84 43 1542 1148 83 0 7 2756
LOC106736614, RET 0 0 31 8 0 0 0 38
HRAS, LRRC56 11 9 7 4 0 0 0 26
LOC130003710, RET 0 0 4 14 0 0 0 17
NTRK1 2 1 14 0 0 0 0 17
KRAS 13 4 0 0 0 0 0 16
SRGAP1 2 0 2 1 0 1 0 6
NRAS 1 3 1 0 0 0 0 5
PIK3CA 0 5 0 0 0 0 0 5
BRAF 2 3 0 0 0 0 1 4
HABP2 0 0 2 2 0 0 0 4
LOC110121502, MCS+9.7, RET 0 0 0 1 3 0 0 4
FOXE1 1 1 0 1 0 0 0 3
INSRR, NTRK1 0 0 3 0 0 0 0 3
LOC130064074, NDUFA13 1 2 0 0 0 0 0 3
MINPP1 3 0 0 0 0 0 0 3
ATM, C11orf65 0 0 2 0 0 0 0 2
LOC106736614, LOC110121502, LOC130003705, LOC130003706, LOC130003707, LOC130003708, LOC130003709, LOC130003710, MCS+9.7, RET 0 0 2 0 0 0 0 2
MEN1 2 0 0 0 0 0 0 2
NKX2-1, SFTA3 1 0 1 0 0 0 0 2
PTEN 1 0 1 0 0 0 0 2
RINT1 0 2 0 0 0 0 0 2
TP53 2 0 0 0 0 0 0 2
AKT1 0 1 0 0 0 0 0 1
ALK 0 0 0 1 0 0 0 1
BARD1 0 0 1 0 0 0 0 1
DHX32 0 0 1 0 0 0 0 1
KIF1B 0 1 0 0 0 0 0 1
LIG4 0 1 0 0 0 0 0 1
PALB2 0 0 1 0 0 0 0 1
PCM1 0 0 1 0 0 0 0 1
SDHA 0 0 1 0 0 0 0 1

Submitter and significance breakdown #

Total submitters: 72
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Submitter pathogenic likely pathogenic uncertain significance likely benign benign risk factor not provided total
Labcorp Genetics (formerly Invitae), Labcorp 73 13 1471 1074 63 0 0 2694
All of Us Research Program, National Institutes of Health 7 4 361 177 4 0 0 553
Fulgent Genetics, Fulgent Genetics 9 1 144 63 2 0 0 219
Counsyl 7 2 84 45 6 0 0 144
Myriad Genetics, Inc. 21 5 20 43 16 0 0 105
Mendelics 2 0 54 13 10 0 0 79
Database of Curated Mutations (DoCM) 19 39 0 0 0 0 1 58
Color Diagnostics, LLC DBA Color Health 3 3 8 17 16 0 0 47
OMIM 42 0 1 0 0 1 0 44
KCCC/NGS Laboratory, Kuwait Cancer Control Center 4 0 2 12 21 0 0 39
St. Jude Molecular Pathology, St. Jude Children's Research Hospital 0 1 29 2 0 0 0 32
Genetics and Molecular Pathology, SA Pathology 2 0 5 0 9 0 0 16
Women's Health and Genetics/Laboratory Corporation of America, LabCorp 12 0 2 0 1 0 0 15
Baylor Genetics 1 2 11 0 0 0 0 14
Laboratory of Molecular and Cytogenetics, Department of Anatomy, All India Institute of Medical Sciences (AIIMS) 7 2 3 1 0 0 0 13
Centre for Mendelian Genomics, University Medical Centre Ljubljana 4 0 5 0 0 0 0 9
Laboratory for Molecular Medicine, Mass General Brigham Personalized Medicine 7 0 0 0 0 0 0 7
MGZ Medical Genetics Center 4 1 2 0 0 0 0 7
CSER _CC_NCGL, University of Washington 1 0 5 1 0 0 0 7
Juno Genomics, Hangzhou Juno Genomics, Inc 5 2 0 0 0 0 0 7
Institute of Human Genetics, University of Leipzig Medical Center 3 0 1 2 0 0 0 6
Center for Human Genetics, Inc, Center for Human Genetics, Inc 3 0 2 0 0 0 0 5
Human Genome Sequencing Center Clinical Lab, Baylor College of Medicine 3 2 0 0 0 0 0 5
Genome-Nilou Lab 0 0 0 0 5 0 0 5
Clinical Molecular Genetics Laboratory, Johns Hopkins All Children's Hospital 4 0 0 0 0 0 0 4
Equipe Genetique des Anomalies du Developpement, Université de Bourgogne 0 0 3 0 1 0 0 4
Department of Pathology and Laboratory Medicine, Sinai Health System 0 0 4 0 0 0 0 4
GenomeConnect - Invitae Patient Insights Network 0 0 0 0 0 0 4 4
Victorian Clinical Genetics Services, Murdoch Childrens Research Institute 3 0 0 0 0 0 0 3
GenomeConnect, ClinGen 0 0 0 0 0 0 3 3
Neuberg Centre For Genomic Medicine, NCGM 1 0 2 0 0 0 0 3
HudsonAlpha Institute for Biotechnology, HudsonAlpha Institute for Biotechnology 2 1 0 0 0 0 0 2
3DMed Clinical Laboratory Inc 2 0 0 0 0 0 0 2
Department of Molecular Diagnostics, Institute of Oncology Ljubljana 2 0 0 0 0 0 0 2
Division of Medical Genetics, Azienda Ospedaliero-Universitaria Policlinico S. Orsola-Malpighi 0 2 0 0 0 0 0 2
GenomeConnect - Brain Gene Registry 0 0 0 0 0 0 2 2
Dept. of Medical Genetics, The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health Commission 0 2 0 0 0 0 0 2
Laboratorio de Genetica e Diagnostico Molecular, Hospital Israelita Albert Einstein 1 0 1 0 0 0 0 2
Greenwood Genetic Center Diagnostic Laboratories, Greenwood Genetic Center 1 0 0 0 0 0 0 1
Biesecker Lab/Clinical Genomics Section, National Institutes of Health 1 0 0 0 0 0 0 1
Genetic Services Laboratory, University of Chicago 1 0 0 0 0 0 0 1
Genomic Diagnostic Laboratory, Division of Genomic Diagnostics, Children's Hospital of Philadelphia 0 0 0 0 1 0 0 1
Columbia University Laboratory of Personalized Genomic Medicine, Columbia University Medical Center 1 0 0 0 0 0 0 1
Center for Genomic Medicine, King Faisal Specialist Hospital and Research Center 0 1 0 0 0 0 0 1
Clinical Genomics Laboratory, Washington University in St. Louis 0 1 0 0 0 0 0 1
Duke University Health System Sequencing Clinic, Duke University Health System 1 0 0 0 0 0 0 1
Foundation for Research in Genetics and Endocrinology, FRIGE's Institute of Human Genetics 0 1 0 0 0 0 0 1
Hadassah Hebrew University Medical Center 1 0 0 0 0 0 0 1
Genome Sciences Centre, British Columbia Cancer Agency 0 1 0 0 0 0 0 1
Soonchunhyang University Bucheon Hospital, Soonchunhyang University Medical Center 0 0 1 0 0 0 0 1
Institute of Human Genetics, University of Wuerzburg 1 0 0 0 0 0 0 1
GenePathDx, GenePath diagnostics 1 0 0 0 0 0 0 1
Institute of Human Genetics, University Hospital of Duesseldorf 0 0 1 0 0 0 0 1
Kamineni Academy of Medical Sciences & Research Centre, Kamineni Hospitals 0 1 0 0 0 0 0 1
Kasturba Medical College, Manipal, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, India 1 0 0 0 0 0 0 1
Center for Molecular Medicine, Children’s Hospital of Fudan University 0 1 0 0 0 0 0 1
Yale Center for Mendelian Genomics, Yale University 0 0 1 0 0 0 0 1
Department of Pediatrics, Memorial Sloan Kettering Cancer Center 1 0 0 0 0 0 0 1
Center for Genomics, Ann and Robert H. Lurie Children's Hospital of Chicago 1 0 0 0 0 0 0 1
Department Of Genetics, Sultan Qaboos University Hospital, Sultan Qaboos University 0 0 1 0 0 0 0 1
Institute of Human Genetics, Heidelberg University 0 1 0 0 0 0 0 1
Johns Hopkins Genomics, Johns Hopkins University 1 0 0 0 0 0 0 1
University Health Network, Princess Margaret Cancer Centre 1 0 0 0 0 0 0 1
Clinical Genomics Laboratory, Stanford Medicine 1 0 0 0 0 0 0 1
New York Genome Center 1 0 0 0 0 0 0 1
Pars Genome Lab 1 0 0 0 0 0 0 1
Institute of Human Genetics, Clinical Exome/Genome Diagnostics Group, University Hospital Bonn 0 1 0 0 0 0 0 1
Suma Genomics 1 0 0 0 0 0 0 1
Clinical Genetics Laboratory, University Hospital Schleswig-Holstein 1 0 0 0 0 0 0 1
Laan Lab, Human Genetics Research Group, University of Tartu 1 0 0 0 0 0 0 1
Molecular Genetics, Royal Melbourne Hospital 0 0 1 0 0 0 0 1
Molecular Genetics and NGS Laboratory, Hospital Fundacion Valle Del Lili 0 1 0 0 0 0 0 1

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