Variants studied for differentiated thyroid carcinoma

Minimum submission review status:		Collection method:
Minimum conflict level: Report conflict between different conditions
Gene type: Distinguish antisense genes from sense genes
Show significances as they were submitted (without aggregation into standard terms)
		ClinVar version:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic	likely pathogenic	uncertain significance	likely benign	benign	risk factor	not provided	total
44	34	181	64	3	1	4	316

Gene and significance breakdown #

Total genes and gene combinations: 22

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Gene or gene combination	pathogenic	likely pathogenic	uncertain significance	likely benign	benign	risk factor	not provided	total
RET	22	23	145	55	3	0	3	238
HRAS, LRRC56	7	2	7	4	0	0	0	19
NTRK1	2	1	14	0	0	0	0	17
SRGAP1	2	0	2	1	0	1	0	6
HABP2	0	0	2	2	0	0	0	4
FOXE1	1	1	0	1	0	0	0	3
INSRR, NTRK1	0	0	3	0	0	0	0	3
LOC106736614, RET	0	0	2	1	0	0	0	3
LOC130064074, NDUFA13	1	2	0	0	0	0	0	3
BRAF	2	0	0	0	0	0	1	2
KRAS	0	2	0	0	0	0	0	2
MINPP1	2	0	0	0	0	0	0	2
NKX2-1, SFTA3	1	0	1	0	0	0	0	2
NRAS	1	0	1	0	0	0	0	2
PTEN	1	0	1	0	0	0	0	2
RINT1	0	2	0	0	0	0	0	2
ATM, C11orf65	0	0	1	0	0	0	0	1
LIG4	0	1	0	0	0	0	0	1
MEN1	1	0	0	0	0	0	0	1
PALB2	0	0	1	0	0	0	0	1
PCM1	0	0	1	0	0	0	0	1
TP53	1	0	0	0	0	0	0	1

Submitter and significance breakdown #

Total submitters: 45

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Submitter	pathogenic	likely pathogenic	uncertain significance	likely benign	benign	risk factor	not provided	total
Fulgent Genetics, Fulgent Genetics	9	1	144	63	2	0	0	219
OMIM	25	0	1	0	0	1	0	27
Database of Curated Mutations (DoCM)	0	18	0	0	0	0	1	19
Mendelics	0	0	15	0	0	0	0	15
Baylor Genetics	1	2	11	0	0	0	0	14
CSER _CC_NCGL, University of Washington	0	0	4	1	0	0	0	5
Juno Genomics, Hangzhou Juno Genomics, Inc	3	2	0	0	0	0	0	5
Genetics and Molecular Pathology, SA Pathology	2	0	2	0	0	0	0	4
Centre for Mendelian Genomics, University Medical Centre Ljubljana	1	0	2	0	0	0	0	3
MGZ Medical Genetics Center	1	1	0	0	0	0	0	2
HudsonAlpha Institute for Biotechnology, HudsonAlpha Institute for Biotechnology	1	1	0	0	0	0	0	2
Department of Pathology and Laboratory Medicine, Sinai Health System	0	0	2	0	0	0	0	2
Department of Molecular Diagnostics, Institute of Oncology Ljubljana	2	0	0	0	0	0	0	2
St. Jude Molecular Pathology, St. Jude Children's Research Hospital	0	1	1	0	0	0	0	2
Neuberg Centre For Genomic Medicine, NCGM	0	0	2	0	0	0	0	2
GenomeConnect - Brain Gene Registry	0	0	0	0	0	0	2	2
Dept. of Medical Genetics, The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health Commission	0	2	0	0	0	0	0	2
Greenwood Genetic Center Diagnostic Laboratories, Greenwood Genetic Center	1	0	0	0	0	0	0	1
Biesecker Lab/Clinical Genomics Section, National Institutes of Health	1	0	0	0	0	0	0	1
Genomic Diagnostic Laboratory, Division of Genomic Diagnostics, Children's Hospital of Philadelphia	0	0	0	0	1	0	0	1
Columbia University Laboratory of Personalized Genomic Medicine, Columbia University Medical Center	1	0	0	0	0	0	0	1
Victorian Clinical Genetics Services, Murdoch Childrens Research Institute	1	0	0	0	0	0	0	1
Center for Genomic Medicine, King Faisal Specialist Hospital and Research Center	0	1	0	0	0	0	0	1
Clinical Genomics Laboratory, Washington University in St. Louis	0	1	0	0	0	0	0	1
Genome Sciences Centre, British Columbia Cancer Agency	0	1	0	0	0	0	0	1
Soonchunhyang University Bucheon Hospital, Soonchunhyang University Medical Center	0	0	1	0	0	0	0	1
Institute of Human Genetics, University of Wuerzburg	1	0	0	0	0	0	0	1
GenePathDx, GenePath diagnostics	1	0	0	0	0	0	0	1
Institute of Human Genetics, University Hospital of Duesseldorf	0	0	1	0	0	0	0	1
Kamineni Academy of Medical Sciences & Research Centre, Kamineni Hospitals	0	1	0	0	0	0	0	1
Kasturba Medical College, Manipal, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, India	1	0	0	0	0	0	0	1
Center for Molecular Medicine, Children’s Hospital of Fudan University	0	1	0	0	0	0	0	1
GenomeConnect, ClinGen	0	0	0	0	0	0	1	1
Center for Genomics, Ann and Robert H. Lurie Children's Hospital of Chicago	1	0	0	0	0	0	0	1
3DMed Clinical Laboratory Inc	1	0	0	0	0	0	0	1
Johns Hopkins Genomics, Johns Hopkins University	1	0	0	0	0	0	0	1
University Health Network, Princess Margaret Cancer Centre	1	0	0	0	0	0	0	1
New York Genome Center	1	0	0	0	0	0	0	1
Pars Genome Lab	1	0	0	0	0	0	0	1
Institute of Human Genetics, Clinical Exome/Genome Diagnostics Group, University Hospital Bonn	0	1	0	0	0	0	0	1
Laan Lab, Human Genetics Research Group, University of Tartu	1	0	0	0	0	0	0	1
Molecular Genetics, Royal Melbourne Hospital	0	0	1	0	0	0	0	1
Laboratorio de Genetica e Diagnostico Molecular, Hospital Israelita Albert Einstein	0	0	1	0	0	0	0	1
Molecular Genetics and NGS Laboratory, Hospital Fundacion Valle Del Lili	0	1	0	0	0	0	0	1
KCCC/NGS Laboratory, Kuwait Cancer Control Center	1	0	0	0	0	0	0	1

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