ClinVar Miner

Variants studied for hereditary photodermatosis

Included ClinVar conditions (57):
Minimum submission review status: Collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign not provided total
858 690 3730 1860 471 41 7168

Gene and significance breakdown #

Total genes and gene combinations: 60
Download table as spreadsheet
Gene or gene combination pathogenic likely pathogenic uncertain significance likely benign benign not provided total
BLM 389 254 2030 1285 87 3 3829
ERCC4 32 26 419 239 50 1 725
XPC 51 96 124 27 30 1 299
POLH 21 14 175 36 40 5 271
RECQL4 23 14 164 26 38 4 261
ERCC2 36 53 116 39 14 2 229
FECH 26 12 61 40 30 1 159
BIVM-ERCC5, ERCC5 19 18 80 20 25 0 150
XPA 31 61 56 12 5 3 147
ERCC3 14 21 72 32 14 0 135
HMBS 63 18 38 9 12 2 126
ALAD 6 2 60 11 13 0 90
CPOX 6 5 26 5 32 1 71
ERCC6 17 20 26 2 5 0 69
PPOX 20 7 35 4 3 2 65
ERCC4, LOC130058543 4 0 39 17 1 0 60
UROS 22 2 22 5 8 9 60
DDB2 6 2 37 10 4 0 56
UROD 16 9 24 4 1 3 52
ERCC8 10 19 4 1 1 0 35
LOC129936244, XPC 3 6 16 2 3 0 27
BIVM-ERCC5, ERCC5, LOC126861834 3 9 15 0 2 0 25
CPOX, LOC129937121 0 0 14 0 10 0 23
TMEM43, XPC 0 0 1 13 10 0 20
ANAPC1 3 4 3 1 7 0 17
ALAS2 4 0 7 0 1 3 13
CRIPT 8 2 2 0 0 0 11
DDB2, LOC126861205 0 1 9 1 1 0 11
ERCC2, KLC3 0 0 8 2 1 0 11
ERCC6, PGBD3 1 5 4 0 1 0 11
HFE 3 1 7 0 0 0 11
LOC129996521, POLH 0 0 9 0 2 0 11
ALAD, LOC130002419 0 0 5 5 0 0 10
ABCB6 0 0 0 2 9 0 9
DPAGT1, HMBS 0 0 0 4 4 0 8
DNA2 5 2 0 0 0 0 6
ERCC6, LOC126860933 1 3 1 0 1 0 6
LOC130001411, RECQL4 0 0 4 0 2 0 6
FECH, LOC130062554 0 0 2 3 0 0 5
UVSSA 3 1 0 0 1 0 5
​intergenic 2 0 2 0 0 0 4
LOC129996520, POLH 0 0 4 0 0 0 4
ALAS2, LOC108663984 0 1 1 0 1 0 3
CLPX 1 1 1 0 1 0 3
BLM, FES, FURIN, HDDC3, MAN2A2, PRC1, RCCD1, UNC45A 0 0 2 0 0 0 2
FECH, LOC129390998 0 0 0 2 0 0 2
FECH, LOC130062560 1 1 0 0 0 0 2
AAGAB, ABHD17C, ABHD2, ACAN, ACSBG1, ACTC1, ADAM10, ADAMTS7, ADAMTSL3, ADPGK, AEN, AFG2B, AGBL1, AKAP13, ALDH1A2, ALPK3, ANKDD1A, ANKRD34C, ANKRD63, ANP32A, ANPEP, ANXA2, AP3B2, AP3S2, AP4E1, APH1B, AQP9, AQR, ARID3B, ARIH1, ARNT2, ARPIN, ARPIN-AP3S2, ARPP19, ATOSA, ATP8B4, AVEN, B2M, BAHD1, BBS4, BCL2A1, BCL2L10, BLM, BLOC1S6, BMF, BNC1, BNIP2, BTBD1, BUB1B, C15orf39, C15orf40, C15orf48, C15orf61, C15orf62, C2CD4A, C2CD4B, CA12, CALML4, CAPN3, CATSPER2, CCDC32, CCDC33, CCDC9B, CCNB2, CCNDBP1, CCPG1, CD276, CDAN1, CDIN1, CELF6, CEMIP, CEP152, CFAP161, CGNL1, CHAC1, CHP1, CHRM5, CHRNA3, CHRNA5, CHRNB4, CHST14, CIAO2A, CIB1, CIB2, CILP, CIMAP1C, CKMT1A, CKMT1B, CLK3, CLN6, CLPX, COMMD4, COPS2, CORO2B, COX5A, CPEB1, CPLX3, CRABP1, CRTC3, CSK, CSNK1G1, CSPG4, CT62, CTDSPL2, CTSH, CTXN2, CYP11A1, CYP19A1, CYP1A1, CYP1A2, DAPK2, DENND4A, DET1, DIS3L, DISP2, DLL4, DMXL2, DNAAF4, DNAJA4, DNAJC17, DPH6, DPP8, DTWD1, DUOX1, DUOX2, DUOXA1, DUOXA2, DUT, EDC3, EFL1, EHD4, EID1, EIF2AK4, EIF3J, ELL3, EMC4, EMC7, EPB42, ETFA, EXD1, FAH, FAM219B, FAM227B, FAM81A, FAM98B, FANCI, FBN1, FBXL22, FBXO22, FEM1B, FGF7, FOXB1, FRMD5, FSD2, FSIP1, GABPB1, GALK2, GANC, GATM, GCHFR, GCNT3, GDPGP1, GJD2, GLCE, GLDN, GNB5, GOLGA6A, GOLGA6B, GOLGA6C, GOLGA6D, GOLGA8A, GOLGA8B, GOLM2, GPR176, GRAMD2A, GREM1, GTF2A2, HACD3, HAPLN3, HAUS2, HCN4, HDC, HERC1, HEXA, HMG20A, HOMER2, HYKK, HYPK, ICE2, IDH2, IDH3A, IGDCC3, IGDCC4, IL16, IMP3, INO80, INSYN1, INTS14, IQCH, IQGAP1, IREB2, ISG20, ISL2, ISLR, ISLR2, ITGA11, ITPKA, IVD, JMJD7, KATNBL1, KBTBD13, KIF23, KIF7, KLHL25, KNL1, KNSTRN, LACTB, LARP6, LCMT2, LCTL, LDHAL6B, LEO1, LINC00928, LINC02694, LINC02915, LINGO1, LIPC, LMAN1L, LOXL1, LPCAT4, LRRC49, LRRC57, LTK, LYSMD2, MAN2C1, MAP1A, MAP2K1, MAP2K5, MAPDA, MAPK6, MAPKBP1, MEGF11, MEIS2, MESD, MESP1, MESP2, MEX3B, MFAP1, MFGE8, MGA, MINAR1, MINDY2, MIR184, MIR9-3, MNS1, MORF4L1, MPI, MRPL46, MRPS11, MTFMT, MTHFS, MYEF2, MYO1E, MYO5A, MYO5C, MYO9A, MYZAP, NDUFAF1, NEDD4, NEIL1, NEO1, NGRN, NMB, NOP10, NOX5, NPTN, NR2E3, NRG4, NTRK3, NUSAP1, NUTM1, OAZ2, OIP5, ONECUT1, PAK6, PAQR5, PARP16, PARP6, PATL2, PCLAF, PDCD7, PDE8A, PDIA3, PEAK1, PEX11A, PGBD4, PHGR1, PIAS1, PIERCE2, PIF1, PIGB, PKM, PLA2G4B, PLA2G4D, PLA2G4E, PLA2G4F, PLCB2, PLEKHO2, PLIN1, PML, POLG, POLR2M, PPCDC, PPIB, PPIP5K1, PPP1R14D, PRTG, PSMA4, PSTPIP1, PTPN9, PYGO1, RAB11A, RAB27A, RAB8B, RAD51, RAMAC, RASGRF1, RASGRP1, RASL12, RBPMS2, RCN2, REC114, RFX7, RHCG, RHOV, RLBP1, RMDN3, RNF111, RNU5A-1, RNU6-1, RORA, RPAP1, RPL4, RPLP1, RPP25, RPS17, RPS27L, RPUSD2, RSL24D1, RTF1, RYR3, SAXO2, SCAMP2, SCAMP5, SCAPER, SCARNA15, SCG3, SCG5, SEC11A, SECISBP2L, SEMA4B, SEMA6D, SEMA7A, SENP8, SERF2, SERINC4, SH2D7, SH3GL3, SHC4, SHF, SIN3A, SKIC8, SKOR1, SLC12A1, SLC12A6, SLC24A1, SLC24A5, SLC27A2, SLC28A1, SLC28A2, SLC30A4, SLC51B, SLTM, SMAD3, SMAD6, SNAP23, SNAPC5, SNUPN, SNX1, SNX22, SNX33, SORD, SPESP1, SPG11, SPG21, SPINT1, SPPL2A, SPRED1, SPTBN5, SQOR, SRP14, ST20, ST20-MTHFS, STARD5, STARD9, STOML1, STRA6, STRC, TBC1D21, TBC1D2B, TCF12, TERB2, TEX9, TGM5, TGM7, THAP10, THBS1, THSD4, TICRR, TIPIN, TLE3, TLN2, TLNRD1, TM6SF1, TMC3, TMCO5A, TMED3, TMEM202, TMEM266, TMEM62, TMEM87A, TMOD2, TMOD3, TNFAIP8L3, TP53BP1, TPM1, TRIM69, TRIP4, TRPM7, TSPAN3, TTBK2, TUBGCP4, TYRO3, UACA, UBAP1L, UBE2Q2, UBL7, UBR1, ULK3, UNC13C, USP3, USP50, USP8, VPS13C, VPS18, VPS39, WDR72, WDR73, WDR76, WDR93, WHAMM, ZFAND6, ZFYVE19, ZNF106, ZNF280D, ZNF592, ZNF609, ZNF710, ZNF770, ZNF774, ZSCAN2, ZSCAN29, ZWILCH 0 0 1 0 0 0 1
ABHD2, ACAN, ANPEP, AP3S2, ARPIN, ARPIN-AP3S2, BLM, CIB1, CRTC3, FANCI, GDPGP1, HAPLN3, IDH2, IQGAP1, KIF7, LINC00928, MESP1, MESP2, MFGE8, MIR9-3, NGRN, PEX11A, PLIN1, POLG, RHCG, RLBP1, SEMA4B, TICRR, WDR93, ZNF710, ZNF774 1 0 0 0 0 0 1
ACO2 1 0 0 0 0 0 1
B4GALT3, PPOX, USP21 1 0 0 0 0 0 1
BLM, LOC130057935 0 0 1 0 0 0 1
CRIPT, PIGF 1 0 0 0 0 0 1
DNA2, LOC132089842, LOC132089843 1 0 0 0 0 0 1
ERCC4, LOC130058543, LOC130058544 1 0 0 0 0 0 1
ERCC4, MIR193B, MIR365A, MRTFB, PARN 0 0 1 0 0 0 1
ERCC8, NDUFAF2 1 0 0 0 0 0 1
FECH, LOC130062555 1 0 1 1 1 0 1
GATA1 0 0 0 0 0 1 1
LOC129930433, UROD 0 0 1 0 0 0 1

Submitter and significance breakdown #

Total submitters: 136
Download table as spreadsheet
Submitter pathogenic likely pathogenic uncertain significance likely benign benign not provided total
Labcorp Genetics (formerly Invitae), Labcorp 393 74 2262 1471 100 0 4300
Illumina Laboratory Services, Illumina 13 4 863 195 271 0 1342
Fulgent Genetics, Fulgent Genetics 107 208 316 32 2 0 665
Natera, Inc. 25 14 489 97 24 0 649
Baylor Genetics 93 167 73 0 0 0 333
Sema4, Sema4 2 8 150 119 12 0 291
Counsyl 24 154 87 5 1 0 271
OMIM 224 0 0 0 0 0 224
KCCC/NGS Laboratory, Kuwait Cancer Control Center 1 0 0 41 110 0 150
Women's Health and Genetics/Laboratory Corporation of America, LabCorp 92 55 0 0 0 0 147
St. Jude Molecular Pathology, St. Jude Children's Research Hospital 12 4 128 0 0 0 144
Mendelics 25 9 52 32 12 0 130
Genome-Nilou Lab 0 1 11 3 96 0 111
Department of Pathology and Laboratory Medicine, Sinai Health System 5 10 62 5 8 0 90
Revvity Omics, Revvity 22 14 23 0 0 0 59
GeneReviews 2 0 0 0 0 31 33
Genomic Medicine Center of Excellence, King Faisal Specialist Hospital and Research Centre 10 10 10 1 0 0 30
Neuberg Centre For Genomic Medicine, NCGM 9 8 13 0 0 0 30
ARUP Laboratories, Molecular Genetics and Genomics, ARUP Laboratories 2 0 4 9 12 0 27
Victorian Clinical Genetics Services, Murdoch Childrens Research Institute 16 1 8 0 1 0 26
3billion 12 4 4 2 0 0 22
Clinical Genetics DNA and cytogenetics Diagnostics Lab, Erasmus MC, Erasmus Medical Center 0 1 3 7 9 0 20
Laboratorio de Genetica e Diagnostico Molecular, Hospital Israelita Albert Einstein 3 8 5 0 0 0 16
Genome Diagnostics Laboratory, Amsterdam University Medical Center 1 0 2 5 7 0 15
Center for Genomics, Ann and Robert H. Lurie Children's Hospital of Chicago 1 0 11 1 1 0 14
Laboratory for Molecular Medicine, Mass General Brigham Personalized Medicine 8 5 0 0 0 0 13
Juno Genomics, Hangzhou Juno Genomics, Inc 6 2 5 0 0 0 13
Medical Molecular Genetics Department, National Research Center 12 0 0 0 0 0 12
Centre for Mendelian Genomics, University Medical Centre Ljubljana 5 0 4 1 2 0 12
Diagnostic Laboratory, Department of Genetics, University Medical Center Groningen 0 0 1 0 10 0 11
MGZ Medical Genetics Center 4 5 0 0 0 0 9
Institute of Human Genetics, University of Leipzig Medical Center 4 2 3 0 0 0 9
Myriad Genetics, Inc. 4 4 1 0 0 0 9
Phillips Lab, Hematology, University of Utah 0 0 0 2 9 0 9
CSER _CC_NCGL, University of Washington 0 1 5 2 0 0 8
Molecular Genetics, Royal Melbourne Hospital 5 2 1 0 0 0 8
Centogene AG - the Rare Disease Company 1 2 4 0 0 0 7
Genetics and Molecular Pathology, SA Pathology 2 3 1 0 1 0 7
GenomeConnect - Invitae Patient Insights Network 0 0 0 0 0 7 7
Claritas Genomics 6 0 0 0 0 0 6
Genomic Research Center, Shahid Beheshti University of Medical Sciences 3 1 2 0 0 0 6
Pathway Genomics 3 0 1 2 0 0 6
Human Genome and Stem Cell Research Center, Department of Genetics and Evolutionary Biology, Institute of Biosciences, University of São Paulo 5 1 0 0 0 0 6
Kasturba Medical College, Manipal, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, India 5 1 0 0 0 0 6
Department of Pediatrics, Memorial Sloan Kettering Cancer Center 3 3 0 0 0 0 6
Institute of Human Genetics Munich, Klinikum Rechts Der Isar, TU München 4 1 0 0 0 0 5
Laboratory of Medical Genetics, National & Kapodistrian University of Athens 3 2 0 0 0 0 5
Reproductive Health Research and Development, BGI Genomics 0 1 3 0 1 0 5
Department of Human Genetics, Hannover Medical School 1 4 0 0 0 0 5
Greenwood Genetic Center Diagnostic Laboratories, Greenwood Genetic Center 1 3 0 0 0 0 4
DNA Repair Laboratory, Institute of Biomedical Sciences - University of Sao Paulo 4 0 0 0 0 0 4
CHU Sainte-Justine Research Center, University of Montreal 0 4 0 0 0 0 4
Knight Diagnostic Laboratories, Oregon Health and Sciences University 0 2 2 0 0 0 4
Equipe Genetique des Anomalies du Developpement, Université de Bourgogne 1 3 0 0 0 0 4
Beijing Key Laboratory for Genetic Research of Skeletal Deformity, Peking Union Medical College Hospital 4 0 0 0 0 0 4
Molecular Diagnostics Laboratory, M Health Fairview: University of Minnesota 1 3 0 0 0 0 4
Genetic Testing Center for Deafness, Department of Otolaryngology Head & Neck Surgery, Institute of Otolaryngology, Chinese PLA General Hospital 4 0 0 0 0 0 4
New York Genome Center 2 0 2 0 0 0 4
Foundation for Research in Genetics and Endocrinology, FRIGE's Institute of Human Genetics 0 2 1 0 0 0 3
Hadassah Hebrew University Medical Center 0 3 0 0 0 0 3
Soonchunhyang University Bucheon Hospital, Soonchunhyang University Medical Center 0 3 0 0 0 0 3
Department of Medical Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences 2 1 0 0 0 0 3
GenomeConnect, ClinGen 0 0 0 0 0 3 3
Endocrinology Department, First Hospital Of Shanxi Medical University 3 0 0 0 0 0 3
Johns Hopkins Genomics, Johns Hopkins University 1 1 0 1 0 0 3
Diagnostics Services (NGS), CSIR - Centre For Cellular And Molecular Biology 1 2 0 0 0 0 3
Mount Sinai Diagnostic Laboratory, Icahn School of Medicine at Mount Sinai 2 0 0 0 1 0 3
Pars Genome Lab 0 0 2 1 0 0 3
Division of Human Genetics, National Health Laboratory Service/University of the Witwatersrand 2 1 0 0 0 0 3
MVZ Medizinische Genetik Mainz 1 0 2 0 0 0 3
Genetic Services Laboratory, University of Chicago 1 1 0 0 0 0 2
Mayo Clinic Laboratories, Mayo Clinic 0 1 1 0 0 0 2
Clinical Genomics Laboratory, Washington University in St. Louis 0 2 0 0 0 0 2
Center for Medical Genetics Ghent, University of Ghent 2 0 0 0 0 0 2
Laboratory of Molecular Oncology, N.N. Petrov Institute of Oncology 0 0 2 0 0 0 2
Institute for Human Genetics and Genomic Medicine, Uniklinik RWTH Aachen 0 1 1 0 0 0 2
Service de Génétique Moléculaire, Hôpital Robert Debré 1 1 0 0 0 0 2
University of Washington Center for Mendelian Genomics, University of Washington 0 2 0 0 0 0 2
Genetic Diagnostic Laboratory, University of Szeged 1 1 0 0 0 0 2
Bioscientia Institut fuer Medizinische Diagnostik GmbH, Sonic Healthcare 0 0 2 0 0 0 2
Undiagnosed Diseases Network, NIH 1 1 0 0 0 0 2
Ege University Pediatric Genetics, Ege University 1 1 0 0 0 0 2
SIB Swiss Institute of Bioinformatics 0 1 0 1 0 0 2
Institute of Medical Genetics and Applied Genomics, University Hospital Tübingen 1 1 0 0 0 0 2
Broad Center for Mendelian Genomics, Broad Institute of MIT and Harvard 1 1 0 0 0 0 2
Department of Molecular Diagnostics, Institute of Oncology Ljubljana 1 1 0 0 0 0 2
Institute for Genomic Statistics and Bioinformatics, University Hospital Bonn 0 0 2 0 0 0 2
Institut de Recherche Interdisciplinaire en Biologie Humaine et Moleculaire, Universite Libre de Bruxelles 2 0 0 0 0 0 2
Al Jalila Children’s Genomics Center, Al Jalila Childrens Speciality Hospital 0 2 0 0 0 0 2
Institute of Human Genetics, University Hospital Muenster 0 1 1 0 0 0 2
Dr. med. U. Finckh, Human Genetics, Eurofins MVZ 1 1 0 0 0 0 2
Clinical Genetics Laboratory, University Hospital Schleswig-Holstein 1 1 0 0 0 0 2
Genomics England Pilot Project, Genomics England 0 2 0 0 0 0 2
Hacettepe Pediatric Genetics Laboratory, Hacettepe University 2 0 0 0 0 0 2
Provincial Medical Genetics Program of British Columbia, University of British Columbia 2 0 0 0 0 0 2
Developmental and Behavioral Pediatrics, First Affiliated Hospital of Jilin University 0 1 1 0 0 0 2
Genomics And Bioinformatics Analysis Resource, Columbia University 0 2 0 0 0 0 2
Dr.Nikuei Genetic Center 1 1 0 0 0 0 2
Paediatric Laboratory, Institute for Maternal and Child Health - IRCCS Burlo Garofolo 2 0 0 0 0 0 2
Institute of Human Genetics, University of Goettingen 1 0 0 0 0 0 1
Center for Individualized Medicine, Mayo Clinic 0 1 0 0 0 0 1
HudsonAlpha Institute for Biotechnology, HudsonAlpha Institute for Biotechnology 1 0 0 0 0 0 1
Center of Genomic medicine, Geneva, University Hospital of Geneva 0 1 0 0 0 0 1
Institute of Human Genetics, University Hospital of Duesseldorf 0 0 1 0 0 0 1
Rady Children's Institute for Genomic Medicine, Rady Children's Hospital San Diego 1 0 0 0 0 0 1
Wangler Lab, Baylor College of Medicine 1 0 0 0 0 0 1
Geisinger Autism and Developmental Medicine Institute, Geisinger Health System 1 0 0 0 0 0 1
Kariminejad - Najmabadi Pathology & Genetics Center 0 1 0 0 0 0 1
StellarGene Technologies Pvt. Ltd. 1 0 0 0 0 0 1
Biochemical Molecular Genetic Laboratory, King Abdulaziz Medical City 0 1 0 0 0 0 1
Medical Genetics, Hospital Clinico Universitario Virgen de la Arrixaca 1 0 0 0 0 0 1
Laboratory of Functional Genomics, Research Centre for Medical Genetics 1 0 0 0 0 0 1
GeneID Lab - Advanced Molecular Diagnostics 0 1 0 0 0 0 1
Genetics and Genomic Medicine Centre, NeuroGen Healthcare, NeuroGen Healthcare 1 0 0 0 0 0 1
Breda Genetics srl 0 1 0 0 0 0 1
Medical Genetics, Medical University Pleven 1 0 0 0 0 0 1
Zotz-Klimas Genetics Lab, MVZ Zotz Klimas 1 0 0 0 0 0 1
Department of Medical Genomics, Royal Prince Alfred Hospital 0 0 0 0 1 0 1
Division of Genomic Medicine, Department of Advanced Medicine, Medical Research Institute, Kanazawa Medical University 1 0 0 0 0 0 1
Clinical Genetics Laboratory, Skane University Hospital Lund 0 1 0 0 0 0 1
Genomics Facility, Ludwig-Maximilians-Universität München 1 0 0 0 0 0 1
Clinical Genomics Laboratory, Stanford Medicine 0 1 0 0 0 0 1
Pediatrics Genetics, Post Graduate Institute of Medical Education and Research 0 0 1 0 0 0 1
Greehey Children's Cancer Research Institute, UT Health San Antonio 1 0 0 0 0 0 1
Suma Genomics 1 0 0 0 0 0 1
Dept. of Cytogenetics, ICMR- National Institute of Immunohaematology 1 0 0 0 0 0 1
DASA 1 0 0 0 0 0 1
Division Of Personalized Genomic Medicine, Columbia University Irving Medical Center 0 0 1 0 0 0 1
Palindrome, Gene Kavoshgaran Aria 1 0 0 0 0 0 1
Center of Laboratory Medicine, Peking Union Medical College Hospital 0 1 0 0 0 0 1
Prenatal Diagnosis Center, Inner Mongolia Medical University 1 0 0 0 0 0 1
Institute of Immunology and Genetics Kaiserslautern 1 0 0 0 0 0 1
Department of Surgical Oncology, and Genetic Counseling Unit of Clinical Genomics Center, Nagasaki University Graduate School of Biomedical Sciences 1 0 0 0 0 0 1
Diagnostics Centre, Carl Von Ossietzky University Oldenburg 1 0 0 0 0 0 1
Royal Medical Services, Bahrain Defence Force Hospital 0 0 1 0 0 0 1
Department of Genetics, Suzhou Beikang Medical Laboratory 0 1 0 0 0 0 1

The information on this website is not intended for direct diagnostic use or medical decision-making without review by a genetics professional. Individuals should not change their health behavior solely on the basis of information contained on this website. Neither the University of Utah nor the National Institutes of Health independently verfies the submitted information. If you have questions about the information contained on this website, please see a health care professional.